Knefel, Matthias Karatzias, Thanos Ben-Ezra, Menachem Cloitre, Marylene Lueger-Schuster, Brigitte Maercker, Andreas
Published in
The British journal of psychiatry : the journal of mental science
The ICD-11 includes a new disorder, complex post-traumatic stress disorder (CPTSD). A network approach to CPTSD will enable investigation of the structure of the disorder at the symptom level, which may inform the development of treatments that target specific symptoms to accelerate clinical outcomes.AimsWe aimed to test whether similar networks of...
Strawbridge, Rebecca Carter, Ben Marwood, Lindsey Bandelow, Borwin Tsapekos, Dimosthenis Nikolova, Viktoriya L Taylor, Rachael Mantingh, Tim de Angel, Valeria Patrick, Fiona
...
Published in
The British journal of psychiatry : the journal of mental science
Depression is considered to have the highest disability burden of all conditions. Although treatment-resistant depression (TRD) is a key contributor to that burden, there is little understanding of the best treatment approaches for it and specifically the effectiveness of available augmentation approaches.AimsWe conducted a systematic review and me...
Mehta, Divya Rex-Haffner, Monika Søndergaard, Helle Bach Pinborg, Anja Binder, Elisabeth B Frokjaer, Vibe G
Published in
The British journal of psychiatry : the journal of mental science
Enhanced sensitivity to oestrogen signalling may drive increased risk for depressive symptoms when exposed to peripartum sex-steroid hormone fluctuations.AimTesting if 116 pre-identified sex steroid-responsive transcripts that predicted perinatal depression (PND) translates to a pharmacological model of hormone-induced mood changes. We generated lo...
Taylor, Matthew J
Published in
The British journal of psychiatry : the journal of mental science
SummaryLithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects is clarified by placebo-controlled randomised trials (3 studies, n = 1120). Lithium reduced relapse into any mood episode over the first 2 weeks of treatment (hazard ratio 0.40, 95% CI 0.16-0.97). Fewer manic r...
Becker, Eva Orellana Rios, Claudia Lorena Lahmann, Claas Rücker, Gerta Bauer, Joachim Boeker, Martin
Published in
The British journal of psychiatry : the journal of mental science
Domany, Yoav Bleich-Cohen, Maya Tarrasch, Ricardo Meidan, Roi Litvak-Lazar, Olga Stoppleman, Nadav Schreiber, Shaul Bloch, Miki Hendler, Talma Sharon, Haggai
...
Published in
The British journal of psychiatry : the journal of mental science
Ketamine has been demonstrated to improve depressive symptoms.AimsEvaluation of efficacy, safety and feasibility of repeated oral ketamine for out-patients with treatment-resistant depression (TRD). In a randomised, double-blind, placebo-controlled, proof-of-concept trial, 41 participants received either 1 mg/kg oral ketamine or placebo thrice week...
Spencer, Benjamin Walter Jack Gergel, Tania Hotopf, Matthew Owen, Gareth S
Published in
The British journal of psychiatry : the journal of mental science
Consent to research with decision-making capacity for research (DMC-R) is normally a requirement for study participation. Although the symptoms of schizophrenia and related psychoses are known to affect decision-making capacity for treatment (DMC-T), we know little about their effect on DMC-R.AimsWe aimed to determine if DMC-R differs from DMC-T in...
Jacobsen, Pamela Hodkinson, Kathleen Peters, Emmanuelle Chadwick, Paul
Published in
The British journal of psychiatry : the journal of mental science
People with psychotic disorders account for most acute admissions to psychiatric wards. Psychological therapies are a treatment adjunct to standard medication and nursing care, but the evidence base for such therapies within in-patient settings is unclear.AimsTo conduct a systematic scoping review of the current evidence base for psychological ther...
Bhui, Kamaldeep
Published in
The British journal of psychiatry : the journal of mental science
Fear, Nicola T Reed, Ruth V Rowe, Sarah Burdett, Howard Pernet, David Mahar, Alyson Iversen, Amy C Ramchandani, Paul Stein, Alan Wessely, Simon
...
Published in
The British journal of psychiatry : the journal of mental science
Little is known about the social and emotional well-being of children whose fathers have been deployed to the conflicts in Iraq/Afghanistan or who have post-traumatic stress disorder (PTSD).AimsTo examine the emotional and behavioural well-being of children whose fathers are or have been in the UK armed forces, in particular the effects of paternal...
