Das-Munshi, Jayati Bakolis, Ioannis Bécares, Laia Dyer, Jacqui Hotopf, Matthew Ocloo, Josephine Stewart, Robert Stuart, Ruth Dregan, Alex
Published in
The British journal of psychiatry : the journal of mental science
Background The association of COVID-19 with death in people with severe mental illnesses (SMI), and associations with multimorbidity and ethnicity are unclear. Aims To determine all-cause mortality in people with SMI following COVID-19 infection and assess whether excess mortality is affected by multimorbidity or ethnicity. Method This was a retros...
Mughal, Faraz Burton, Fiona M Fletcher, Harriet Lascelles, Karen O’Connor, Rory C Rae, Sarah Thomson, Alex Kapur, Nav
Published in
The British journal of psychiatry : the journal of mental science
Zhou, Ziyi Lo, Camilla K M Chan, Ko Ling Chung, Rachel S Y Pell, Jill P Minnis, Helen Shiels, Paul G Ip, Patrick Ho, Frederick K
Published in
The British journal of psychiatry : the journal of mental science
There is evidence that child maltreatment is associated with shorter telomere length in early life. This study aims to examine if child maltreatment is associated with telomere length in middle- and older-age adults. This was a retrospective cohort study of 141 748 UK Biobank participants aged 37-73 years at recruitment. Leukocyte telomere length w...
Canal-Rivero, Manuel Ruiz-Veguilla, Miguel Ortiz-García de la Foz, Victor López-Díaz, Alvaro Garrido-Torres, Nathalia Ayesa-Arriola, Rosa Vazquez-Bourgon, Javier Mayoral-van Son, Jacqueline Brambilla, Paolo Kircher, Tilo
...
Published in
The British journal of psychiatry : the journal of mental science
Understanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture the progression of this condition and the associated brain changes. To explore the factors underlying negative symptoms and their association with long-term abnormal brain trajectories. We followed up 357 peop...
O'Brien, Kathleen J Ered, Arielle Korenic, Stephanie A Olino, Thomas M Schiffman, Jason Mittal, Vijay A Ellman, Lauren M
Published in
The British journal of psychiatry : the journal of mental science
Evidence suggests that both childhood trauma and perceived stress are risk factors for the development of psychosis, as well as negative symptoms such as anhedonia. Previous findings link increases in perceived stress to anhedonia in individuals at clinical high risk for psychosis (CHR) and depression; however, the role of childhood trauma in this ...
Ahangari, Mohammad Bustamante, Daniel Kirkpatrick, Robert Nguyen, Tan-Hoang Verrelli, Brian C Fanous, Ayman Kendler, Kenneth S Webb, Bradley T Bacanu, Silviu-Alin Riley, Brien P
...
Published in
The British journal of psychiatry : the journal of mental science
Psychotic disorders and schizotypal traits aggregate in the relatives of probands with schizophrenia. It is currently unclear how variability in symptom dimensions in schizophrenia probands and their relatives is associated with polygenic liability to psychiatric disorders. To investigate whether polygenic risk scores (PRSs) can predict symptom dim...
Wolpe, Noham Chen, Shanquan Kirkpatrick, Brian Jones, Peter B Jenkins, Christopher Cardinal, Rudolf N Fernandez-Egea, Emilio
Published in
The British journal of psychiatry : the journal of mental science
Negative symptoms of schizophrenia manifest as reduced motivation and pleasure (MAP) and impaired emotional expressivity (EXP). These can occur as primary phenomena, but have also been suggested to occur secondary to other clinical factors, including antipsychotic-induced sedation. However, this relationship has not been established formally. Here,...
Northwood, Korinne Pearson, E Arnautovska, U Kisely, S Pawar, M Sharma, M Vitangcol, K Wagner, E Warren, N Siskind, Dan
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Published in
The British journal of psychiatry : the journal of mental science
Although clozapine is the most efficacious medication for treatment-refractory schizophrenia, not all patients will have an adequate response. Optimising clozapine dose using therapeutic drug monitoring could therefore maximise response. Using individual patient data, we undertook a receiver operating characteristic (ROC) curve analysis to determin...
Sjöstrand, Manne Eyal, Nir
Published in
The British journal of psychiatry : the journal of mental science
Governments and non-governmental organisations are increasingly adopting a 'zero-suicide' goal, but what such a goal precisely involves is unclear. Ostensibly it strongly prioritises the prevention and elimination of all suicide. We argue that, so understood, a societal goal of zero suicide risks contravening several ethical principles. In terms of...
Burnett, Alexander C R Wong, Quincy Zeritis, Stephanie Deady, Mark Torok, Michelle
Published in
The British journal of psychiatry : the journal of mental science
Previous research showed that the Global Financial Crisis (GFC) was associated with a widening disparity in suicide rates between lower-class occupations and the highest-class occupations in Australia. There has been no research investigating whether this trend continued post-GFC. This study aimed to investigate suicide rates by occupational class ...
