Chesson, A L Jr Anderson, W M Walls, R C Bairnsfather, L E
Published in
The American review of respiratory disease
A method of recording cumulative nocturnal oxygen desaturation was utilized to develop a quantitative index of nocturnal hypoxemia (SIT index) to provide reference values and distributional properties for apneic and nonapneic sleep-disordered patients. The SIT indices were compared in patients with varying degrees of obstructive sleep apnea (OSA) a...
Kennedy, N Fox, R Kisyombe, G M Saruni, A O Uiso, L O Ramsay, A R Ngowi, F I Gillespie, S H
Published in
The American review of respiratory disease
The early bactericidal and sterilizing activities of ciprofloxacin were evaluated in the treatment of adult patients with smear positive pulmonary tuberculosis. Two randomized prospective studies were performed in Northern Tanzania. In study 1, ten patients received either 750 mg ciprofloxacin or 300 ng isoniazid daily for 7 days. Counts of colony-...
Roche, W R Montefort, S Baker, J Holgate, S T
Published in
The American review of respiratory disease
The bronchial epithelium is the major barrier between the host and the provoking antigens in bronchial asthma. Recent studies have indicated that the epithelium is a truly stratified structure, with the superficial columnar cells depending on the underlying basal cells for anchorage. Only columnar cells are shed into bronchial lavage fluid. The epi...
Thomas, D A Swaminathan, S Beardsmore, C S McArdle, E K MacFadyen, U M Goodenough, P C Carpenter, R Simpson, H
Published in
The American review of respiratory disease
The peripheral chemoresponses of infant twin pairs were determined using a single-breath hyperoxic stimulus. A total of 43 twin pairs of comparable gestation and birth weight were studied during sleep at a mean (SD) age of 8 wk (1.4) while alternately breathing either air or 16% oxygen in nitrogen. Infants responded to a single breath of 100% oxyge...
Meuer, S C Schraven, B Samstag, Y
Published in
The American review of respiratory disease
A multitude of glycoproteins expressed in cellular membranes have been identified by monoclonal antibodies. Besides mediating transient cell/cell contacts, these molecules unequivocally function as receptor structures capable of transmitting signals for cell growth and differentiation. They are the central determinators of local immune responses, a...
Wallace, J M Rao, A V Glassroth, J Hansen, N I Rosen, M J Arakaki, C Kvale, P A Reichman, L B Hopewell, P C
Published in
The American review of respiratory disease
Although the pulmonary complications of advanced human immunodeficiency virus (HIV) infection have been well described, there is little information on respiratory manifestations of earlier disease. This report describes the respiratory disorders diagnosed over an 18-month period in a cohort of persons with or at risk for HIV infection with variable...
Rosenberg, T Manfreda, J Hershfield, E S
Published in
The American review of respiratory disease
This study examined the prevalence and determinants of tuberculin reactors and the booster response in 272 (97%) residents and 218 (69%) staff of an urban nursing home where a case of miliary TB was being investigated. Many subjects were foreign born (56%), and 15% had a history of BCG vaccination (34% of staff). Testing was done with 5 TU PPD-S (C...
Högman, M Frostell, C G Hedenström, H Hedenstierna, G
Published in
The American review of respiratory disease
We studied whether nitric oxide (NO), added at 80 ppm to inspired gas, can exert a bronchodilatory effect in humans. Four groups were studied: (1) healthy adult volunteers (n = 6), (2) adult subjects with hyperreactive airways (n = 6) during provocation with inhaled methacholine (MCh), (3) patients with bronchial asthma (n = 13), and (4) patients w...
Bentsen, K D Nielsen, T L Eaftinck Schattenkerk, J K Jensen, B N Lundgren, J D
Published in
The American review of respiratory disease
Inflammation may play a central role in the pathogenesis of HIV-related Pneumocystis carinii pneumonia (PCP). Serum levels of the amino-terminal propeptide of Type III procollagen (PIIINP) reflect inflammatory activity in granulation tissue and in chronic rheumatic and liver disorders. To investigate changes in PIIINP serum levels during an episode...
Martin, R J Boguniewicz, M Henson, J E Celniker, A C Williams, M Giorno, R C Leung, D Y
Published in
The American review of respiratory disease
Recent studies suggest that cytokines such as recombinant interferon-gamma (rIFN-gamma) may play a role in the treatment of certain respiratory conditions associated with infection and inflammation. This study was designed to determine if rIFN-gamma could be delivered effectively in a group of normal human volunteers. The effectiveness of the inhal...
