Akilesh, Shreeram Nicosia, Roberto F Alpers, Charles E Tretiakova, Maria Hsiang, Tien-Ying Gale, Michael Jr Smith, Kelly D
Published in
The American journal of pathology
The severe acute respiratory syndrome coronavirus 2 pandemic has infected millions of individuals in the United States and caused hundreds of thousands of deaths. Direct infection of extrapulmonary tissues has been postulated, and using sensitive techniques, viral RNA has been detected in multiple organs in the body, including the kidney. However, ...
Blair, Robert V Vaccari, Monica Doyle-Meyers, Lara A Roy, Chad J Russell-Lodrigue, Kasi Fahlberg, Marissa Monjure, Chris J Beddingfield, Brandon Plante, Kenneth S Plante, Jessica A
...
Published in
The American journal of pathology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of disease severity, ranging from asymptomatic infection to a life-threating illness, particularly in the elderly population and persons with comorbid conditions. Among those persons with serious coronavirus 2019 (COVID-19) disease, acute respiratory distress syndrome...
Plotkin, Matthew O'Brien, Charles A Goellner, Joseph Williams, Joshua Carter, Weleetka Sharma, Shree Stone, Annjanette
Published in
The American journal of pathology
We identified a family with a UMOD gene mutation (C106F) resulting in glomerular inflammation and complement deposition. To determine if the observed phenotype is due to immune system activation by mutant uromodulin, a mouse strain with a homologous cysteine to phenylalanine mutation (C105F) in the UMOD gene was generated using CRISPR-Cas9 gene edi...
Zheng, Yijing Chen, Yuemiao Lu, Xiaolang Weng, Qihao Dai, Gaole Yu, Yang Yu, Kehe Gao, Weiyang
Published in
The American journal of pathology
Because chondrocytes are the only resident cells in articular cartilage, the steady state of these cells is important for the maintenance of joint function. In various osteoarthritis diseases, chondrocytes undergo a series of pathophysiologic changes, leading to the loss of chondrocytes and the degradation of extracellular matrix (ECM). This study ...
Yang, Shuchun Yang, Rui Wang, Huanmin Huang, Yue Jia, Yuyan
Published in
The American journal of pathology
CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) plays a crucial role in mammalian liver development and hepatic function by controlling hepatocyte proliferation and differentiation, glucose and lipid metabolism, UFMylation, and endoplasmic reticulum homeostasis. However, the role of CDK5RAP3 in liver regeneration remains unknown. A liver-sp...
Cheng, Jerome Y Abel, Jacob T Balis, Ulysses G J McClintock, David S Pantanowitz, Liron
Published in
The American journal of pathology
Significant advances in artificial intelligence (AI), deep learning, and other machine-learning approaches have been made in recent years, with applications found in almost every industry, including health care. AI has proved to be capable of completing a spectrum of mundane to complex medically oriented tasks previously performed only by boarded p...
Park, Sun-Ji Li, Chuang Chen, Ying Maggie
Published in
The American journal of pathology
Calcium (Ca2+) homeostasis is a crucial determinant of cellular function and survival. Endoplasmic reticulum (ER) acts as the largest intracellular Ca2+ store that maintains Ca2+ homeostasis through the ER Ca2+ uptake pump, sarco/ER-Ca2+ ATPase, ER Ca2+ release channels, inositol 1,4,5-trisphosphate receptor channel, ryanodine receptor, and Ca2+-bi...
Hung, Li-Yin Pastore, Christopher F Douglas, Bonnie Herbert, De'Broski R
Published in
The American journal of pathology
IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate inflammation. It is controversial whether IL-33 serves a pathogenic or protective role during inflammatory bowel disease. Herein, two different strains of cell-specific conditionally deficient mice were used to compare the role of myeloid- versus intestinal...
McCarron, Alexandra Parsons, David Donnelley, Martin
Published in
The American journal of pathology
Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated for research purposes. Species, including mice, rats, ferrets, rabbits, pigs, sheep, zebrafish, and fruit flies, have all been used to model CF disease. Access to such a variety of animal models is a luxury for any research field, but it also complicates the d...
Masuzaki, Ryota Ray, Kevin C Roland, Joseph Zent, Roy Lee, Youngmin A Karp, Seth J
Published in
The American journal of pathology
A unique and complex microstructure underlies the diverse functions of the liver. Breakdown of this organization, as occurs in fibrosis and cirrhosis, impairs liver function and leads to disease. The role of integrin β1 was examined both in establishing liver microstructure and recreating it after injury. Embryonic deletion of integrin β1 in the li...
