Liang, Qianqian Zhang, Li Wood, Ronald W Ji, Rui-Cheng Boyce, Brendan F Schwarz, Edward M Wang, Yongjun Xing, Lianping
Published in
The American journal of pathology
NF-κB signals through canonical RelA/p50 and noncanonical RelB/p52 pathways. The RelA/p50 is involved in basal and inflammatory lymphangiogenesis. However, the role of RelB/p52 in lymphatic vessel biology is unknown. Here, we investigated changes in lymphatic vessels (LVs) in mice deficient in noncanonical NF-κB signaling, and the function of RelB ...
Laursen, Emma Bollmann Fredsøe, Jacob Schmidt, Linnéa Strand, Siri Kristensen, Helle Ildor Rasmussen, Anne Karin Daugaard, Tina Fuglsang Mouritzen, Peter Høyer, Søren Kristensen, Gitte
...
Published in
The American journal of pathology
miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with non-malignant controls, however its prognostic potential and functional role in PC remains largely unknown. In this study, we investigated the clinical and biological relevance of miR-615-3p in PC. The expression of miR-615-3p was measured ...
Pilling, Darrell Cox, Nehemiah Thomson, Megan A Karhadkar, Tejas R Gomer, Richard H
Published in
The American journal of pathology
High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high affinity IgG receptor Fcγ receptor I (FcγRI; CD64) and the lectin receptor DC-SIGN (CD209). Here, we show that for mice on a HFD, injections of SAP and a synthetic CD209 li...
Mencke, Rik Umbach, Anja T Wiggenhauser, Lucas M Voelkl, Jakob Olauson, Hannes Harms, Geert Bulthuis, Marian Krenning, Guido Quintanilla-Martinez, Leticia van Goor, Harry
...
Published in
The American journal of pathology
Hyalinosis is a vascular lesion affecting the renal vasculature and contributing to ageing-related renal function decline. We assessed whether arteriolar hyalinosis is caused by Klotho deficiency - a state known to induce both renal and vascular phenotypes associated with ageing. Histochemistry was used to assess hyalinosis in Klotho-/- kidneys, co...
Otsuka, Kunihiro Yamada, Akiko Saito, Masako Ushio, Aya Sato, Mami Kisoda, Satoru Shao, Wenhua Tsunematsu, Takaaki Kudo, Yasusei Arakaki, Rieko
...
Published in
The American journal of pathology
Follicular helper T (Tfh) cells contribute to various immune responses as well as to the pathogenesis of several immune diseases. However, the precise mechanism underlying the onset or development of autoimmunity via Tfh cells remains unclear. Here, the detailed relationship between autoimmune disease and Tfh cells was analyzed using a murine model...
Sobierajska, Katarzyna Wawro, Marta Ewelina Ciszewski, Wojciech Michał Niewiarowska, Jolanta
Published in
The American journal of pathology
Fibrotic disorders, which are caused by long-term inflammation, are observed in numerous organs. These disorders are regulated mainly through transforming growth factor (TGF)-β family proteins by a fundamental cellular mechanism, known as the endothelial-mesenchymal transition. Therefore, there is a pressing need to identify the mechanisms and pote...
Soroosh, Artin Rankin, Carl R Polytarchou, Christos Lokhandwala, Zulfiqar A Patel, Ami Chang, Lin Pothoulakis, Charalabos Iliopoulos, Dimitrios Padua, David M
Published in
The American journal of pathology
Inflammatory bowel disease is characterized by high levels of inflammation and loss of barrier integrity in the colon. The intestinal barrier is a dynamic network of proteins that encircle intestinal epithelial cells. miRNAs regulate protein-coding genes. In this study, miR-24 was found to be elevated in colonic biopsies and blood samples from ulce...
Sheehan, Susan Mawe, Seamus Cianciolo, Rachel E Korstanje, Ron Mahoney, J Matthew
Published in
The American journal of pathology
With the advent and increased accessibility of deep neural networks (DNNs), complex properties of histologic images can be rigorously and reproducibly quantified. We used DNN-based transfer learning to analyze histologic images of periodic acid-Schiff-stained renal sections from a cohort of mice with different genotypes. We demonstrate that DNN-bas...
Baumann, Bailey H Shu, Wanting Song, Ying Sterling, Jacob Kozmik, Zbynek Lakhal-Littleton, Samira Dunaief, Joshua L
Published in
The American journal of pathology
The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels. Hepc accomplishes this by triggering degradation of the only known cellular iron exporter ferroportin in the gut, macrophages, and liver. We previously demonstrated that systemic Hepc knockout (HepcKO) mice, which have high serum iron, develop retinal iron overload...
Yan, Shengmin Zhou, Jun Chen, Xiaoyun Dong, Zheng Yin, Xiao-Ming
Published in
The American journal of pathology
Alcoholic fatty liver disease is often complicated by other pathologic insults, such as viral infection or high-fat diet. Autophagy plays a homeostatic role in the liver but can be compromised by alcohol, high-fat diet, or viral infection, which in turn affects the disease process caused by these etiologies. To understand the full impact of autopha...
