Zhao, Xingxing Ding, Liang Lu, Zhanyi Huang, Xiaofeng Jing, Yue Yang, Yan Chen, Sheng Hu, Qingang Ni, Yanhong
Published in
The American journal of pathology
Although cancer-associated fibroblasts (CAFs) are crucial stromal cells, characterizing their heterogeneity is far from complete. This study reports a novel subset of CAFs in oral squamous cell carcinoma (OSCC), which positively expressed CD68, the classic marker of macrophages. The spatial and temporal distribution of the CD68+ CAF subset of OSCC ...
Kosar, Karis Cornuet, Pamela Singh, Sucha Liu, Silvia Nejak-Bowen, Kari
Published in
The American journal of pathology
Chronic cholestasis results from bile secretory defects or impaired bile flow with few effective medical therapies available. Thyroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as GC-1, are known to impact lipid and bile acid (BA) metabolism and induce hepatocyte proliferation downstream of Wnt/β-catenin signalin...
Balic, Jesse J Saad, Mohamed I Dawson, Ruby West, Alice J McLeod, Louise West, Alison C D'Costa, Kimberley Deswaerte, Virginie Dev, Anouk Sievert, William
...
Published in
The American journal of pathology
Gastric cancer is associated with chronic inflammation (gastritis) triggered by infection with the Helicobacter pylori (H. pylori) bacterium. Elevated tyrosine phosphorylation of the latent transcription factor STAT3 is a feature of gastric cancer, including H. pylori-infected tissues, and is aligned to nuclear transcriptional activity. By contrast...
Midgley, Adam C Woods, Emma L Jenkins, Robert H Brown, Charlotte Khalid, Usman Chavez, Rafael Hascall, Vincent Steadman, Robert Phillips, Aled O Meran, Soma
...
Published in
The American journal of pathology
Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme that is broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive; thus the mechanisms through which HYAL2 dysregulation influences pathobiology are unclear. Recent...
Li, Yuan Chao, Xiaojuan Wang, Shaogui Williams, Jessica A Ni, Hong-Min Ding, Wen-Xing
Published in
The American journal of pathology
Chronic alcohol consumption induces adipose tissue atrophy. However, the mechanisms for how alcohol induces lipodystrophy and its impact on liver steatosis and injury are not fully elucidated. Autophagy is a highly conserved lysosomal degradation pathway, which regulates cellular homeostasis. Mice with autophagy deficiency in adipose tissue have im...
Narla, Sridhar T Bushnell, Daniel S Schaefer, Caitlin M Nouraie, Mehdi Bates, Carlton M
Published in
The American journal of pathology
Keratinocyte growth factor (KGF) improves cyclophosphamide-induced bladder injury. To understand the mechanisms, we subcutaneously administered KGF to mice 24 hours before i.p. cyclophosphamide administration, followed by histologic assays and immunostaining. In vehicle (phosphate-buffered saline)-pretreated mice, nonapoptotic superficial cell deat...
Shults, Nataliia V Rybka, Vladyslava Suzuki, Yuichiro J Brelidze, Tinatin I
Published in
The American journal of pathology
Kv11.1 potassium channels are essential for heart repolarization. Prescription medication that blocks Kv11.1 channels lengthens the ventricular action potential and causes cardiac arrhythmias. Surprisingly little is known about the Kv11.1 channel expression and function in the lung tissue. Here we report that Kv11.1 channels were abundantly express...
Manocha, Ujjawal Kardos, Jordan Selitsky, Sara Zhou, Mi Johnson, Steven M Breslauer, Cori Epstein, Jonathan I Kim, William Y Wobker, Sara E
Published in
The American journal of pathology
Lymphoepithelioma-like carcinoma of the bladder (LELC-B) is a rare subtype of urothelial carcinoma consisting of undifferentiated epithelial cells within a dense inflammatory cell infiltrate. We set out to molecularly characterize LELC-B through RNA expression profiling as well as immunohistochemistry (IHC) to understand its underlying biology. Six...
Zhou, Zhou Ye, Ting Jie DeCaro, Elizabeth Buehler, Brian Stahl, Zachary Bonavita, Gregory Daniels, Michael You, Min
Published in
The American journal of pathology
Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD+-dependent protein deacetylase, is implicated in the pathogenesis of alcoholic liver disease (ALD). However, the role of intestinal SIRT1 in ALD is presently unknown. This study investigated the involvement of intestine-specific SIRT1 in ethanol-induced liver dysfunction in mice. Ethanol feeding stu...
Turner, Suzanne D Inghirami, Giorgio Miranda, Roberto N Kadin, Marshall E
Published in
The American journal of pathology
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Nearly all cases have been associated with textured implants. Most cases are of effusion-limited, indolent disease, with an excellent prognosis after implant and capsule removal. However, capsular invasion and...
