Cheng, Jerome Y Abel, Jacob T Balis, Ulysses G J McClintock, David S Pantanowitz, Liron
Published in
The American journal of pathology
Significant advances in artificial intelligence (AI), deep learning, and other machine-learning approaches have been made in recent years, with applications found in almost every industry, including health care. AI is capable of completing a spectrum of mundane to complex medically oriented tasks previously performed only by boarded physicians, mos...
O'Hare, Michael Amarnani, Dhanesh Whitmore, Hannah A B An, Miranda Marino, Claudia Ramos, Leslie Delgado-Tirado, Santiago Hu, Xinyao Chmielewska, Natalia Chandrahas, Anita
...
Published in
The American journal of pathology
Pulmonary fibrosis (PF) can arise from unknown causes, as in idiopathic PF, or as a consequence of infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current treatments for PF slow, but do not stop, disease progression. We report that treatment with a RUNX1 inhibitor (Ro24-7429), previously found to be safe, althoug...
Castro-Martinez, Felipe Candelario-Martinez, Aurora Encarnacion-Garcia, Maria Del Rocio Piedra-Quintero, Zayda Bonilla-Moreno, Raul Betanzos, Abigail Perez-Orozco, Rocio Hernandez-Cueto, Maria de Los Angeles Muñoz-Medina, Jose Esteban Patiño-Lopez, Genaro
...
Published in
The American journal of pathology
Epithelial barrier impairment is a hallmark of several pathological processes in the gut, including inflammatory bowel diseases. Several intracellular signals prevent apoptosis in intestinal epithelial cells. Here we shown that in colonocytes, rictor/mTORC2 signaling is a pro-survival stimulus. Mechanistically, mTORC2 activates Akt which in turns i...
Whitmore, Hannah A B Kim, Leo A
Published in
The American journal of pathology
SARS-CoV-2 was originally identified as an outbreak in Wuhan, China towards the end of 2019 and quickly became a global pandemic, with a large death toll. Originally identified as a respiratory disease, similar to previously discovered SARS and MERS type viruses, concern has since been raised about the effects of SARS-CoV-2 infection on the vascula...
Warren, Bryce D Ahn, Soo Hyun Brittain, Kathryn Nanjappa, Manjunatha K Wang, Hao Wang, Jianrong Blanco, Gustavo Sanchez, Gladis Fan, Yong Petroff, Brian K
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Published in
The American journal of pathology
Male factors, including those of autoimmune origin, contribute to approximately 50% of infertility cases in humans. However, the mechanisms underlying autoimmune male infertility are poorly understood. Deficiency in autoimmune regulator (AIRE) impairs central immune tolerance because of diminished expression of self-antigens in the thymus. Humans w...
Lee, Seoung-Woo Baek, Su-Min Kang, Kyung-Ku Lee, A-Rang Kim, Tae-Un Choi, Seong-Kyoon Roh, Yoon-Seok Hong, Il-Hwa Park, Sang-Joon Kim, Tae-Hwan
...
Published in
The American journal of pathology
Despite the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD), little is known about its underlying pathogenesis or specific treatment. The senescence marker protein 30 (SMP30), which regulates the biosynthesis of vitamin C in many mammals except primates and humans, was recently recognized as a gluconolactonase. However, t...
Pathak, Lekhika Gayan, Sukanya Pal, Bidisha Talukdar, Joyeeta Bhuyan, Seema Sandhya, Sorra Yeger, Herman Baishya, Debabrat Das, Bikul
Published in
The American journal of pathology
We postulate that similar to bacteria, adult stem cells may also exhibit an altruistic defense mechanism to protect their niche against external threat. Herein, we report mesenchymal stem cell (MSC)-based altruistic defense against a mouse model of coronavirus, murine hepatitis virus-1 (MHV-1) infection of lung. MHV-1 infection led to reprogramming...
Howard, Zachary M Lowe, Jeovanna Blatnik, Anton J 3rd Roberts, Deztani Burghes, Arthur H M Bansal, Shyam S Rafael-Fortney, Jill A
Published in
The American journal of pathology
Duchenne muscular dystrophy (DMD) is a genetic, degenerative, striated muscle disease exacerbated by chronic inflammation. Mdx mice in the genotypic DMD model poorly represent immune-mediated pathology observed in patients. Improved understanding of innate immunity in dystrophic muscles is required to develop specific anti-inflammatory treatments. ...
de Souza, Rodrigo G Yu, Zhiyuan Hernandez, Humberto Trujillo-Vargas, Claudia M Lee, Andrea Mauk, Kelsey E Cai, Jiyang Alves, Milton R de Paiva, Cintia S
Published in
The American journal of pathology
Inflammation and oxidative stress accompany aging. This study investigated the interplay between oxidative stress and inflammation in the lacrimal gland. C57BL/6 mice were used at 2 to 3, 12, and 24 months of age. Nuclear factor erythroid derived-2-related factor 2 (Nrf2)-/- and corresponding wild-type mice were used at 2 to 3 and 12 to 13 months o...
Akilesh, Shreeram Nicosia, Roberto F Alpers, Charles E Tretiakova, Maria Hsiang, Tien-Ying Gale, Michael Jr Smith, Kelly D
Published in
The American journal of pathology
The severe acute respiratory syndrome coronavirus 2 pandemic has infected millions of individuals in the United States and caused hundreds of thousands of deaths. Direct infection of extrapulmonary tissues has been postulated, and using sensitive techniques, viral RNA has been detected in multiple organs in the body, including the kidney. However, ...
