Zhang, Yiyin Wu, Hongyang Yang, Feng Ning, Jie Li, Min Zhao, Chenchen Zhong, Shuping Gu, Kangsheng Wang, Hua
Published in
The American journal of pathology
Alcohol consumption likely induces gastric carcinogenesis through deregulation of RNA polymerase (Pol) III genes and oxidative damage. Transcription factor IIB-related factor 1 (BRF1) overexpression alleviates RNA Pol III transcription inhibition through breast cancer susceptibility gene 1 (BRCA1). Myeloperoxidase (MPO) involvement in cancer is ind...
Yu, Dongfang Saini, Yogesh Chen, Gang Ghio, Andrew J Dang, Hong Burns, Kimberlie A Wang, Yang Davis, Richard M Randell, Scott H Esther, Charles R Jr
...
Published in
The American journal of pathology
Human subjects with pseudohypoaldosteronism-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction. A conditional βENaC MG knockout (KO) mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and associated ocular surface disease. βENaC MG KO m...
Knuuttila, Matias Mehmood, Arfa Huhtaniemi, Riikka Yatkin, Emrah Häkkinen, Merja R Oksala, Riikka Laajala, Teemu D Ryberg, Henrik Handelsman, David J Aittokallio, Tero
...
Published in
The American journal of pathology
The development of castration-resistant prostate cancer (CRPC) is associated with the activation of intratumoral androgen biosynthesis and an increase in androgen receptor (AR) expression. We recently demonstrated that, similarly to the clinical CRPC, orthotopically grown castration-resistant VCaP (CR-VCaP) xenografts express high levels of AR and ...
Lai, Beibei Zou, Jianghuan Lin, Zhaoyu Qu, Zhipeng Song, Anying Xu, Ying Gao, Xiang
Published in
The American journal of pathology
The neuropeptides arginine vasopressin (Avp) and vasoactive intestinal polypeptide (Vip) are critical for the communication and coupling of suprachiasmatic nucleus neurons, which organize daily rhythms of physiology and behavior in mammals. However, how these peptides are regulated remains uncharacterized. We found that heterogeneous nuclear ribonu...
Furie, Martha B
Published in
The American journal of pathology
This Editorial describes new enhanced scope of The American Journal of Pathology and introduces its new editorial team.
Ashar, Harshini K Mueller, Nathan C Rudd, Jennifer M Snider, Timothy A Achanta, Mallika Prasanthi, Maram Pulavendran, Sivasami Thomas, Paul G Ramachandran, Akhilesh Malayer, Jerry R
...
Published in
The American journal of pathology
Although exaggerated host immune responses have been implicated in influenza-induced lung pathogenesis, the etiologic factors that contribute to these events are not completely understood. We previously demonstrated that neutrophil extracellular traps exacerbate pulmonary injury during influenza pneumonia. Histones are the major protein components ...
Mangus, Lisa M Beck, Sarah E Queen, Suzanne E Brill, Samuel A Shirk, Erin N Metcalf Pate, Kelly A Muth, Dillon C Adams, Robert J Gama, Lucio Clements, Janice E
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Published in
The American journal of pathology
A retrospective neuropathologic review of 30 SIV-infected pigtailed macaques receiving combination antiretroviral therapy (cART) was conducted. Seventeen animals with lymphocyte-dominant inflammation in the brain and/or meninges that clearly was morphologically distinct from prototypic SIV encephalitis and human immunodeficiency virus encephalitis ...
Krupar, Rosemarie Hautmann, Matthias G Pathak, Ravi R Varier, Indu McLaren, Cassandra Gaag, Doris Hellerbrand, Claus Evert, Matthias Laban, Simon Idel, Christian
...
Published in
The American journal of pathology
Tumor immune microenvironment and tumor metabolism are major determinants of chemoradiotherapy response. The interdependency and prognostic significance of specific immune and metabolic phenotypes in head and neck squamous cell carcinoma (HNSCC) were assessed and changes in reactive oxygen species were evaluated as a mechanism of treatment response...
Puri, Pawan Schaefer, Caitlin M Bushnell, Daniel Taglienti, Mary E Kreidberg, Jordan A Yoder, Bradley K Bates, Carlton M
Published in
The American journal of pathology
Ectopic cAMP signaling is pathologic in polycystic kidney disease; however, its spatiotemporal actions are unclear. We characterized the expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling, in developing and cystic kidney models. We also examined tubule-specific effects of cAMP analogs in cystogenesis in embryonic ki...
Kusters, Pascal Seijkens, Tom Bürger, Christina Legein, Bart Winkels, Holger Gijbels, Marion Barthels, Christian Bennett, Remy Beckers, Linda Atzler, Dorothee
...
Published in
The American journal of pathology
The costimulatory molecule CD40 is a major driver of atherosclerosis. It is expressed on a wide variety of cell types, including mature dendritic cells (DCs), and is required for optimal T-cell activation and expansion. It remains undetermined whether and how CD40 on DCs impacts the pathogenesis of atherosclerosis. Here, the effects of constitutive...
