Liang, Qianqian Zhang, Li Wood, Ronald W Ji, Rui-Cheng Boyce, Brendan F Schwarz, Edward M Wang, Yongjun Xing, Lianping
Published in
The American journal of pathology
NF-κB signals through canonical transcription factor p65 (RelA)/p50 and noncanonical avian reticuloendotheliosis viral oncogene related B (RelB)/p52 pathways. The RelA/p50 is involved in basal and inflammatory lymphangiogenesis. However, the role of RelB/p52 in lymphatic vessel biology is unknown. Herein, we investigated changes in lymphatic vessel...
Laursen, Emma B Fredsøe, Jacob Schmidt, Linnéa Strand, Siri H Kristensen, Helle Rasmussen, Anne K I Daugaard, Tina F Mouritzen, Peter Høyer, Søren Kristensen, Gitte
...
Published in
The American journal of pathology
miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with nonmalignant controls; however, its prognostic potential and functional role in PC remain largely unknown. In this study, we investigated the clinical and biological relevance of miR-615-3p in PC. The expression of miR-615-3p was measured i...
Pilling, Darrell Cox, Nehemiah Thomson, Megan A Karhadkar, Tejas R Gomer, Richard H
Published in
The American journal of pathology
High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high-affinity IgG receptor Fcγ receptor I (FcγRI; CD64) and the lectin receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN; CD209). ...
Mencke, Rik Umbach, Anja T Wiggenhauser, Lucas M Voelkl, Jakob Olauson, Hannes Harms, Geert Bulthuis, Marian Krenning, Guido Quintanilla-Martinez, Leticia van Goor, Harry
...
Published in
The American journal of pathology
Hyalinosis is a vascular lesion affecting the renal vasculature and contributing to aging-related renal function decline. We assessed whether arteriolar hyalinosis is caused by Klotho deficiency, a state known to induce both renal and vascular phenotypes associated with aging. Histochemistry was used to assess hyalinosis in Klotho-/- kidneys, compa...
Otsuka, Kunihiro Yamada, Akiko Saito, Masako Ushio, Aya Sato, Mami Kisoda, Satoru Shao, Wenhua Tsunematsu, Takaaki Kudo, Yasusei Arakaki, Rieko
...
Published in
The American journal of pathology
Follicular helper T (Tfh) cells contribute to various immune responses as well as to the pathogenesis of several immune diseases. However, the precise mechanism underlying the onset or development of autoimmunity via Tfh cells remains unclear. Herein, the detailed relationship between autoimmune disease and Tfh cells was analyzed using a murine mod...
Sobierajska, Katarzyna Wawro, Marta E Ciszewski, Wojciech M Niewiarowska, Jolanta
Published in
The American journal of pathology
Fibrotic disorders, which are caused by long-term inflammation, are observed in numerous organs. These disorders are regulated mainly through transforming growth factor (TGF)-β family proteins by a fundamental cellular mechanism, known as the endothelial-mesenchymal transition. Therefore, there is a pressing need to identify the mechanisms and pote...
Zhang, Dong Yang, Xiao-Jie Luo, Qi-Dong Fu, De-Lai Li, Zhao-Lun Zhang, Peng Chong, Tie
Published in
The American journal of pathology
Many studies have recognized that circular RNAs (circRNAs) can be promising targets for renal cell carcinoma (RCC) by acting as competing endogenous RNAs for miRNAs. This study intends to uncover the implication of a novel circRNA, circ_000926 in RCC, and how it affects tumorigenesis. Microarray-based circRNA/gene expression profiling of RCC was us...
Zhou, Tianwei E Zhu, Tang Rivera, José C Omri, Samy Tahiri, Houda Lahaie, Isabelle Rouget, Raphaël Wirth, Maëlle Nattel, Stanley Lodygensky, Gregory
...
Published in
The American journal of pathology
Retinopathy of prematurity (ROP) is characterized by an initial retinal avascularization, followed by pathologic neovascularization. Recently, choroidal thinning has also been detected in children formerly diagnosed with ROP; a similar sustained choroidal thinning is observed in ROP models. But the mechanism underlying the lack of choroidal revascu...
Volk-Draper, Lisa Patel, Radhika Bhattarai, Nihit Yang, Jie Wilber, Andrew DeNardo, David Ran, Sophia
Published in
The American journal of pathology
Lymphatic metastasis is a high-impact prognostic factor for mortality of breast cancer (BC) patients, and it directly depends on tumor-associated lymphatic vessels. We previously reported that lipopolysaccharide-induced inflammatory lymphangiogenesis is strongly promoted by myeloid-derived lymphatic endothelial cell progenitors (M-LECPs) derived fr...
Wilkinson, Holly N Roberts, Elizabeth R Stafford, Amber R Banyard, Kayleigh L Matteucci, Paolo Mace, Kimberly A Hardman, Matthew J
Published in
The American journal of pathology
Macrophages are important for effective iron recycling and erythropoiesis, but they also play a crucial role in wound healing, orchestrating tissue repair. Recently, we demonstrated a significant accumulation of iron in healing wounds and a requirement of iron for effective repair. Herein, we sought to determine the influence of iron on macrophage ...
