Chang, Wei-Tien Li, Chang-Qing Hsu, Chin-Wan Lee, Chunpei Huang, Hsien-Hao Yuan, Chun-Su Chen, Wen-Jone Vanden Hoek, Terry L Shao, Zuo-Hui Li, Jing
...
Published in
The American journal of Chinese medicine
Baicalein is a natural flavonoid with anti-oxidant activities protecting against ischemia/reperfusion (I/R) injury. Previous studies suggest that oxidative burst early after reperfusion accelerates cell death. We therefore investigated the critical therapeutic window of baicalein by examining the timing of baicalein treatment in relation to its oxi...
Luo, Yun Wang, Chong-Zhi Hesse-Fong, Julia Lin, Jaung-Geng Yuan, Chun-Su
Published in
The American journal of Chinese medicine
Western medicine is routinely used in developed nations as well as in Eastern countries, where traditional medicine is frequently used by a selection of patients or family member as a complement to mainstream Western medicine. Chinese medicine plays an important role in the treatment of chronic diseases, especially when Western medicine is not very...
Zhang, Yalin Su, Han Zhang, Juan Kong, Juan
Published in
The American journal of Chinese medicine
Hyperuricemia is a metabolic disease of the kidney that results in decreased uric acid excretion. Here, we aimed to investigate the effects of ginsenosides and anserine on hyperuricemia and the expression of aquaporin (AQP) 1-4, which are indicators of renal excretion. Ginsenosides and anserine were administered separately or together after the est...
Yang, Lihong Chen, Jing Lu, Huanyu Lai, Jiaqi He, Yihan Liu, Shaonan Guo, Xinfeng
Published in
The American journal of Chinese medicine
Gegen (Radix Puerariae Lobatae), the root of Pueraria lobata, is an edible and medicinal herb which has been used in treating diabetic symptoms in the orient for thousands of years. We present an evidence map of the efficacy and safety of Gegen and Gegen formulas (GGFs) that use Gegen as an essential herb for diabetes, and also its mechanism of act...
Choi, Jang-Gi Lee, Heeeun Kim, Young Soo Hwang, Youn-Hwan Oh, You-Chang Lee, Bonggi Moon, Kyoung Mi Cho, Won-Kyung Ma, Jin Yeul
Published in
The American journal of Chinese medicine
Aloe vera ethanol extract (AVE) reportedly has significant anti-influenza virus activity, but its underlying mechanisms of action and constituents have not yet been completely elucidated. Previously, we have confirmed that AVE treatment significantly reduces the viral replication of green fluorescent protein-labeled influenza A virus in Madin-Darby...
Feng, Rui Ding, Fan Mi, Xiu-Hua Liu, Shu-Fen Jiang, Ai-Ling Liu, Bi-Hui Lian, Yin Shi, Qi Wang, Yong-Jun Zhang, Yan
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Published in
The American journal of Chinese medicine
Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR). This study aimed to explore the potency of ligustroflavone as a CaSR antagonist and its pro...
Peng, Li-Ying An, Lin Sun, Ning-Yuan Ma, Yi Zhang, Xiao-Wei Liu, Wen-Hua Liu, Bao-Lin Li, Ping Chen, Jun
Published in
The American journal of Chinese medicine
Pulmonary fibrosis (PF) is characterized by myofibroblast activation, which can be triggered by oxidative stress. In this study, we investigated the antifibrotic effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on PF and examined the underlying molecular mechanism. EASM suppressed myofibroblast activation with reduced extracellular...
Liu, Zai-Qun
Published in
The American journal of Chinese medicine
Anti-oxidant refers to such a kind of endogenous or exogenous compound that is able to retard or even prohibit in vivo or in vitro oxidation with only small amount being used. The study of anti-oxidants starts nearly 30 years ago, and the research on this topic in China almost begins simultaneously with that in the world. Gratifyingly, contribution...
Kim, Ha Na Park, Gwang Hun Park, Su Bin Kim, Jeong Dong Eo, Hyun Ji Son, Ho-Jun Song, Jeong Ho Jeong, Jin Boo
Published in
The American journal of Chinese medicine
Sageretia thea (S. thea) commonly known as Chinese sweet plum or Chinese bird plum has been used for treating hepatitis and fevers in Korea and China. S. thea has been reported to exert anti-oxidant, anticancer and anti-human immunodeficiency virus activity. However, there is little study on the anti-inflammatory activity of S. thea. Thus, we evalu...
Li, Tonghua Zhang, Yuyang Tian, Jianwei Yang, Lu Wang, Jianchang
Published in
The American journal of Chinese medicine
Ginkgo biloba extracts (EGb) alleviate myocardial ischemia/reperfusion (MI/R) injury. However, the underlying mechanisms have not yet been characterized. This study aimed to investigate whether activation of large-conductance Ca2+-activated K+ channels at the inner mitochondrial membrane (mitoBKCa) of cardiomyocytes is involved in Ginkgo biloba ext...
