Chen, Jiamei Li, Xuewei Hu, Yonghong Liu, Wei Zhou, Qun Zhang, Hua Mu, Yongping Liu, Ping
Published in
The American journal of Chinese medicine
Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear. Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks. T...
Chen, Na Wang, Jing Mucelli, Attilio Zhang, Xu Wang, Changqing
Published in
The American journal of Chinese medicine
Knee osteoarthritis (KOA) is a common chronic degenerative disease of the elderly. Electro-acupuncture (EA) is considered as a beneficial treatment for KOA, but the conclusion is controversial. This systematic review compiled the evidence from 11 randomized controlled trials to objectively assess the effectiveness and safety of EA for KOA. Eight da...
Ma, Chengyao Chen, Yayun Chen, Jianwei Li, Xiang Chen, Yong
Published in
The American journal of Chinese medicine
Annona squamosa L. (Annonaceae) is a fruit tree with a long history of traditional uses. A. squamosa is an evergreen plant mainly located in tropical and subtropical regions. Srikayas, the fruits of A. squamosa, are extensively used to prepare candies, ice creams and beverages. A wide range of ethno-medicinal uses has been related to different port...
Wang, Chenggui Lou, Yiting Xu, Jianxiang Feng, Zhenhua Chen, Yu Tang, Qian Wang, Qingqing Jin, Haiming Wu, Yaosen Tian, Naifeng
...
Published in
The American journal of Chinese medicine
Microglial activation leads to increased production of proinflammatory enzymes and cytokines, which is considered to play crucial role in neurodegenerative diseases, however there are only a few drugs that target microglia activation. Recent studies have indicated that the Traditional Chinese Medicine, salidroside (Sal), exerted anti-inflammatory e...
Wu, Xiao-Ming Gao, Yan-Bin Xu, Li-Ping Zou, Da-Wei Zhu, Zhi-Yao Wang, Xiao-Lei Yao, Wei-Jie Luo, Liang-Tao Tong, Yu Tian, Nian-Xiu
...
Published in
The American journal of Chinese medicine
Glomerular mesangial cells (GMCs) activation is implicated in the pathogenesis of diabetic nephropathy (DN). Our previous study revealed that high glucose (HG)-treated glomerular endothelial cells (GECs) produce an increased number of TGF-[Formula: see text]1-containing exosomes to activate GMCs through the TGF-[Formula: see text]1/Smad3 signaling ...
Wang, Dawei Yu, Weiqing Liu, Yuntao Zhong, Guofu Zhao, Zhen Yan, Xia Liu, Qing
Published in
The American journal of Chinese medicine
Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective funct...
Takayama, Shin Kaneko, Soichiro Numata, Takehiro Kamiya, Tetsuharu Arita, Ryutaro Saito, Natsumi Kikuchi, Akiko Ohsawa, Minoru Kohayagawa, Yoshitaka Ishii, Tadashi
...
Published in
The American journal of Chinese medicine
Large-scale natural disasters, such as earthquakes, tsunamis, volcanic eruptions, and typhoons, occur worldwide. After the Great East Japan earthquake and tsunami, our medical support operation's experiences suggested that traditional medicine might be useful for treating the various symptoms of the survivors. However, little information is availab...
An, Lin Zhou, Mei Marikar, Faiz M M T Hu, Xue-Wen Miao, Qiu-Yun Li, Ping Chen, Jun
Published in
The American journal of Chinese medicine
Diabetic nephropathy (DN) is a common cause of chronic kidney disease and end-stage renal disease, which can be triggered by oxidative stress. In this study, we investigated the renoprotective effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on DN and examined the underlying molecular mechanism. We observed that EASM treatment atte...
Okubo, Shinya Uto, Takuhiro Goto, Aya Tanaka, Hiroyuki Nishioku, Tsuyoshi Yamada, Katsushi Shoyama, Yukihiro
Published in
The American journal of Chinese medicine
Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproli...
Kim, Dae-Seung Kim, Sung-Hee Kee, Ji-Ye Han, Yo-Han Park, JinBong Mun, Jeong-Geon Joo, Moon-Jung Jeon, Yong-Deok Kim, Su-Jin Park, Sang-Hyun
...
Published in
The American journal of Chinese medicine
Eclipta prostrata (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, ...
