Devi, Sushma Rangra, Naresh Kumar Rawat, Ravi Alrobaian, Majed M Alam, Aftab Singh, Randhir Singh, Akanksha
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Steroids
Atherogenic dyslipidemia is a condition and responsible for the induction of major cardiovascular diseases. Traditionally, Nepeta hindostana a medicinal plant commonly used as cardioprotective in Indo-Pak regions has gained importance because of its therapeutic active flavonoid Nepitrin-7-O-glucoside. Flavonoid-glycosides are steroids having the ab...
Baranovsky, Alexander Ladyko, Alesya Shkel, Tatsiana Sokolov, Sergey Strushkevich, Natallia Gilep, Andrey
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Steroids
The synthesis and NMR structure analysis of a group of oxygenated steroids containing isoxazole, dihydrofuran, tetrahydrofuran rings or enamino carbonyl fragment in the side chain have been fulfilled. The prepared compounds were tested toward several enzymes (human cytochrome P450s CYP17, CYP19, CYP51 and CYP51 of pathogenic fungus Candida glabrata...
Mukherjee, Victor Ramakrishna, Premalatha Bora, Sushmita Kotteazeth, Srikumar
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Steroids
Oxysterols are natural ligands of certain nuclear receptors known as liver X receptors (LXR). LXRs are regulators of fatty acid, cholesterol, and glucose homeostasis. Dietary phyto-oxysterol 28-homobrassinolide (28-HB) has been demonstrated to transactivate rat LXR α and β. In this study we assessed the potential of 28-HB to effect such changes in ...
de Souza, Samira Itana Rocha, Edilene Cândido Ferraz, Halanna Rocha Dias, Jéssica Afonso Seguro, Antonio Carlos Volpini, Rildo Aparecido Canale, Daniele de Bragança, Ana Carolina Shimizu, Maria Heloisa Massola Marques, Lucas Miranda
...
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Steroids
Although several studies have demonstrated that the male gender represents an independent risk factor for renal disease, evidence shows that androgens exert renal protective actions. The findings are controversial and no studies have evaluated the effects of orchiectomy and testosterone replacement on glycerol-induced renal injury. Male Wistar rats...
Yi, Weimin Li, Xue Chen, Ke Zhu, Min Cai, Xuehua Pan, Aizhen
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Steroids
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. Cangfu Daotan Decoction (CFDTT) is one of the prescriptions in the stagnation of obesity-type PCOS. Our previous study showed that CFDTT treatment of obese PCOS was correlated with organic anion transporting polypeptides (OATPs). Here...
Ibrahim, Iman Atia-Tul-Wahab, Khan, Nisha Siddiqui, Mahwish Hassan Ajandouz, El Jabeen, Almas Mesmar, Joelle Baydoun, Elias Iqbal Choudhary, M
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Steroids
Biotransformation of an orally active contraceptive drug, desogestrel (1), with Cunninghamella elegans yielded a new metabolite, 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3,6-dione (2), along with five known metabolites, i.e., 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3β,6β,17β-triol (3), 13β-ethyl-11-methylene-18...
Sun, Mo-Ran Kang, Ying-Ying Duan, Yong-Tao Liu, Hong-Min
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Steroids
An efficient and concise synthesis of 2-methoxyestradiol (4) from 17β-estradiol (1) has been achieved in three synthetic steps with a 63.3% overall yield. The key step was the palladium-catalyzed direct C(sp2)-H methoxylation of 2-aryloxypyridines. Using 2-pyridyloxyl as the directing group, Pd(OAc)2 as the catalyst, PhI(OAc)2 as the oxidant and me...
Yoshimura, Yusuke Togashi, Moeka Ogawa, Shoujiro Higashi, Tatsuya
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Steroids
A variety of metabolites derived from 25-hydroxyvitamin D3 [25(OH)D3], including its 3-epimer [Epi-25(OH)D3] and 3-O-sulfate [25(OH)D3-3S], is found in human plasma/serum. We hypothesized that the 3-O-sulfate of Epi-25(OH)D3 [Epi-25(OH)D3-3S] might be present in plasma/serum. Clarifying this point could improve our understanding of the metabolism o...
Ruan, Jingya Sun, Fan Zhang, Ying Zheng, Dandan Xiang, Guilin Zhao, Wei Zhang, Yi Wang, Tao
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Steroids
Through the combination of various chromatographies, 11 new 20(S)-protopanaxadiol (PPD) type saponins, named as notoginsenosides NL-E1 - NL-E4 (1-4), NL-F1 (5), NL-F2 (6), NL-G1 (7), NL-G2 (8), NL-H1 - NL-H3 (9-11) were obtained from the leaves of Panax notoginseng. Their structures were ascertained based on the extensive spectroscopic methods and ...
Gutiérrez Nicolás, Fátima Casero, Carina N Pacciaroni, Adriana Del Valle Leiva González, Segundo Barboza, Gloria E Nicotra, Viviana E
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Steroids
Five Exodeconus species were phytochemically analyzed. From the aerial parts of E. pusillus, the 7α,27-dihydroxy-1-oxo-22R-witha-2,5,24-trienolide and three other previously unreported normal-type withanolides were isolated. All the studied species had normal type and/or ring-D aromatic withanolides, and some had already been isolated from other So...