Pospieszny, Tomasz Koenig, Hanna
Published in
Steroids
New four steroid conjugates have been prepared from bile acids and sterol derivatives using click chemistry method. The azide-alkyne Huisgen cycloaddition (intermolecular 1,3-dipolar cycloaddition) of the propargyl ester of lithocholic, deoxycholic, cholic acid as well as dehydrocholic acids and azide derivatives of cholesterol gave a new bile acid...
Zhu, Yan Qiu, Lei Jiang, Fangfang Găman, Mihnea-Alexandru Abudoraehem, Ohoud Saleh Okunade, Kehinde S Zhang, Ming
Published in
Steroids
Estradiol, an estrogen steroid hormone, serves as the dominant female hormone and its levels fluctuate during lifetime. In women, after the menopause, all estrogens and almost all androgens are locally developed in the peripheral tissues from dehydroepiandrosterone (DHEA). However, the effect of DHEA supplementation on estradiol levels in women is ...
Lei, Kelu Yuan, Minghao Zhou, Tao Ye, Qiang Zeng, Bin Zhou, Qiang Wei, Ailing Guo, Li
Published in
Steroids
Bile acid transporters are highly expressed in intestinal cells and hepatocytes, and they determine the uptake of drugs in cells by modulating cellular entry and exit. In order to improve the oral bioavailability of drugs and investigate the potential application prospects of drugs used to target cancer, numerous studies have adopted these transpor...
Sun, Menghu Cao, Yuju Wang, Tiantian Liu, Tingting An, Feimeng Wu, Huiqiang Wang, Jianzhong
Published in
Steroids
Steroid-induced osteonecrosis of the femoral head (ONFH) is a complex disease affected by genetics. LncRNA LINC-PINT and LINC00599 have been proved to be associated with susceptibility to a variety of diseases, however it is not clear whether they are related to steroid-induced ONFH. Therefore, this study was aimed at investigating the correlation ...
Niromand, Elham Javanmardy, Setareh Salimi, Zahra Zarei, Fatemeh Khazaei, Mohammad Rasool
Published in
Steroids
In recent years the expanding misuse of Nandrolone among non-athletes, particularly adolescent males is a prevalent global concern due to its adverse effects. This article provides a summary of the experimental studies to clarify the relationship between Nandrolone exposure and behavioral and cognitive performances. The present systematic review wa...
Francis, Prima Chakraborty, Kajal
Published in
Steroids
Two pregnane-type of steroid derivatives characterized as 5α-pregna-3β-methyl pent-3-enoate-12β, 16β diol-20-one (clathroid A) and 12β,15β- dihydroxypregna-4,6-diene-3,20-dione (clathroid B) were purified from the crude extract of the marine sponge, Clathria (Thalysias) vulpina (family Microcionidae) by extensive chromatographic fractionation. Spec...
Chakraborty, Kajal Joy, Minju Raola, Vamshi Krishna
Published in
Steroids
Four biogenic β-sitosterol analogues were identified from methanolic extract of the leaves of loop-root mangrove Rhizophora mucronata. These were characterized as 4, 14, 23-trimethyl-3β-sitosterol (1), 7-ethyl-3β-sitosterol (2), sitosteryl-3β-(33E)-pent-33-enoate (3) and 12α-hydroxy-3β-sitosterol (4) based on comprehensive spectroscopic techniques....
Zhu, Zhiling Liu, Zhiping Cui, Jianguo Huang, Yanmin Chen, Hualong Wu, Yulan Huang, Xiaotong Gan, Chunfang
Published in
Steroids
In this work, a series of Biotin-substituted B-nor-cholesteryl benzimidazole compounds were synthesized. The antiproliferativeactivities of these compounds were evaluated in vitro using a series of human cancer cell lines, including HeLa (cervical cancer), SKOV3 (ovarian cancer), T-47D (thymus gland cancer), MCF-7 (human breast cancer) and HEK293T ...
Alqahtani, Yahya S
Published in
Steroids
Natural product is a well-known source of bioactive compounds. Herein, a steroidal compound stigmasta-7,22-diene-3-one (stigmastadienone) has been isolated from Isodon rugosus. The potency of isolated compound has been tested for several in-vitro targets. The acetyl and butyrylcholinesterase assays were performed using Ellman's procedure. For the i...
Lin, Juntong Deng, Langjing Sun, Mingwei Wang, Yao Lee, Sangwoo Choi, Kyungho Liu, Xiaoshan
Published in
Steroids
The endocrine disruption potency of BPA was reported elsewhere, but the mechanisms of its analogues have not been fully resolved. In this study, endocrine disruption potentials of nine alternative bisphenol analogues, namely 2,2-bis(4-hydroxyphenyl)butane (BPB), 2,2-Bis(4-hydroxy-3-methylphenyl)propane (BPC), 4,4'-dihydroxydiphenylmethane (BPF), 4,...
