Nishimura, Yoko Moriya, Kimihiko Kobayashi, Sumitaka Araki, Atsuko Sata, Fumihiro Mitsui, Takahiko Itoh, Sachiko Miyashita, Chihiro Cho, Kazutoshi Kon, Masafumi
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Steroids
Phthalates and bisphenol A (BPA) are estrogenic endocrine disruptors. Polymorphisms in the gene encoding estrogen receptor 1 (ESR1) may contribute to the ratio of the lengths of the second and fourth digits (2D:4D), which is considered an index of prenatal exposure to sex hormones. Thus, we investigated whether ESR1 polymorphisms modify the effects...
Akinwumi, Idayat A Sonibare, Mubo A Yeye, Emmanuel O Khan, Majid
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Steroids
Sphenocentrum jollyanum seeds (MeOH extract and n butanol fraction) exhibited urease inhibitory activity (IC50 40.0±0.92, 28.6±0.41). The Ethyl acetate (EtOAc) fraction gave significant antacid activity with an increase in the baseline pH value of 1.2 to 1.61±0.00 and 1.53±0.00 at 50 and 100 mg, respectively, compared to the antacid activity of sod...
Rainville, Jennifer R Weiss, Grant L Evanson, Nathan Herman, James P Vasudevan, Nandini Tasker, Jeffrey G
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Steroids
Nawasreh, Mansour M Alzyoud, Elham I Al-Mazaydeh, Zainab A Rammaha, Majdoleen S Yasin, Salem R Tahtamouni, Lubna H
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Steroids
Cephalostatin 1, a potent anti-cancer agent, is a natural bis-steroidal alkaloid that causes cell death in the subnanomolar to picomolar ranges via an atypical apoptosis pathway. Although cephalostatin 1 is a highly effective anticancer drug, its availability limits its utilization. We previously reported the synthesis of two 12'α-hydroxy derivativ...
Li, Hongling Wang, Haijun Wang, Jing Lin, Yu Ma, Yukun Bu, Ming
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Steroids
A series of novel 5α, 8α-endoperoxide steroidal hybrid derivatives containing isatin or indole substituents on the C-17 side chain were synthesized and characterized. The preliminary anti-proliferative activity of the compounds against HepG2, MCF-7, HT-29 and HeLa cell lines were investigated. Compounds 7g and 7l displayed significant anti-prolifer...
Jin, Lin-Yu Song, Xiao-Xing Li, Xin-Feng
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Steroids
Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays...
Túlio C Pessôa, Marco Valadares, Jéssica M M Rocha, Sayonarah C Silva, Simone C McDermott, Jeff P Sánchez, Gladis Varotti, Fernando P Scavone, Cristóforo Ribeiro, Rosy I M A Villar, José A F P
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Steroids
Cardiotonic steroids (CTS) are agents traditionally known for their capacity to bind to the Na,K-ATPase (NKA), affecting the ion transport and the contraction of the heart. Natural CTS have been shown to also have effects on cell signaling pathways. With the goal of developing a new CTS derivative , we synthesized a new digoxin derivative, 21-benzy...
Huml, Lukáš Havlová, Dominika Longin, Ondřej Staňková, Eliška Holubová, Barbora Kuchař, Martin Prokudina, Elena Rottnerová, Zdeňka Zimmermann, Tomáš Drašar, Pavel
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Steroids
Two valuable forensic tools based on enzyme-linked immunoassays (ELISAs) for the analysis of 17α-methylated steroids were developed using haptens of stanazolol and its conjugates with biotin. Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA). Eight batches of an...
Daniela Voegel, Clarissa Hofmann, Mathias Kraemer, Thomas Baumgartner, Markus R Maria Binz, Tina
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Steroids
Steroid hormone analysis is widely used in health- and stress-related research to get insights into various diseases and the adaption to stress. Hair analysis has been used as a tool for the long-term monitoring of these steroid hormones. In this study, a liquid chromatography-tandem mass spectrometry method was developed and validated for the simu...
Kiss, Anita Wölfling, János Mernyák, Erzsébet Frank, Éva Benke, Zsanett Ashkan Senobar Tahaei, Seyyed Zupkó, István Mahó, Sándor Schneider, Gyula
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Steroids
The four possible isomers of each of 3-methoxy- and 3-benzyloxyestra-1,3,5(10)-trien-17-ols (5-8 and 9-12) were converted through 16-p-tosyloxymethyl- or 16-bromomethyl derivatives into their 3-methoxy- and 3-benzyloxy-16-azidomethylestra(1,3,5(10)-triene derivatives (13-16 and 17-20). The regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of...
