Park, Hyun-Ji De Jesus Morales, Kenneth J Bheri, Sruti Kassouf, Brandon P Davis, Michael E
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Stem cells (Dayton, Ohio)
Ischemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsu...
Colussi, Claudia Grassi, Claudio
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Stem cells (Dayton, Ohio)
Nucleoporins (Nups) are components of the nuclear pore complex that, besides regulating nucleus-cytoplasmic transport, emerged as a hub for chromatin interaction and gene expression modulation. Specifically, Nups act in a dynamic manner both at specific gene level and in the topological organization of chromatin domains. As such, they play a fundam...
Lubanska, Dorota Qemo, Ingrid Byrne, Megan Matthews, Kaitlyn N Fifield, Bre-Anne Brown, Jillian da Silva, Elizabeth Fidalgo Porter, Lisa A
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Stem cells (Dayton, Ohio)
Fully differentiated cells can be reprogrammed through ectopic expression of key transcription factors to create induced pluripotent stem cells. These cells share many characteristics of normal embryonic stem cells and have great promise in disease modeling and regenerative medicine. The process of remodeling has its limitations, including a very l...
Pouyanfard, Somayeh Meshgin, Nairika Cruz, Luisjesus S Diggle, Karin Hashemi, Hamidreza Pham, Timothy V Fierro, Manuel Tamayo, Pablo Fanjul, Andrea Kisseleva, Tatiana
...
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Stem cells (Dayton, Ohio)
With an increasing number of patients with degenerative hepatic diseases, such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophages that are capable of phagocytosis and anti-inflammatory activities such as secretion of matrix meta...
Tran, Linda L Dang, Truong Thomas, Rintu Rowley, David R
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Stem cells (Dayton, Ohio)
Stromal cells in the tumor microenvironment regulate the immune landscape and tumor progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is not well understood. Carcinoma-associated fibroblasts exhibiting an inflammatory phenotype (iCAFs) have been identified within multiple cancers; however, mechanisms that lead...
Dey, Anusree Uppal, Sheetal Giri, Jayeeta Misra, Hari Sharan
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Stem cells (Dayton, Ohio)
Understanding the mechanism of fate decision and lineage commitment is the key step for developing novel stem cell applications in therapeutics. This process is coordinately regulated through systematic epigenetic reprogramming and concomitant changes in the transcriptional landscape of the stem cells. One of the bromo- and extra-terminal domain (B...
Herman, Shay Fishel, Idan Offen, Daniel
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Stem cells (Dayton, Ohio)
Neurological disorders are diseases of the central nervous system (CNS), characterized by a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem cells (MSCs) are a promising therapy for diseases and disorders of the CNS. Increasing evidence suggests that their beneficial abilities can be attributed to their parac...
Vaka, Ramana Davis, Darryl R
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Stem cells (Dayton, Ohio)
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the "state-of-play" of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing...
Chandrasekaran, Abinaya Jensen, Pia Mohamed, Fadumo A Lancaster, Madeline Benros, Michael E Larsen, Martin R Freude, Kristine K
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Stem cells (Dayton, Ohio)
Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is ind...
Rosner, Margit Hengstschläger, Markus
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Stem cells (Dayton, Ohio)
Three-dimensional (3D) cell migration is an integral part of many physiologic processes. Although being well studied in the context of adult tissue homeostasis and cancer development, remarkably little is known about the invasive behavior of human stem cells. Using two different kinds of invasion assays, this study aimed at investigating and charac...
