Trinh, Linh T Osipovich, Anna B Liu, Bryan Shrestha, Shristi Cartailler, Jean-Philippe Wright, Christopher V E Magnuson, Mark A
Published in
Stem cells (Dayton, Ohio)
During early embryogenesis, the transcription factor SOX17 contributes to hepato-pancreato-biliary system formation and vascular-hematopoietic emergence. To better understand Sox17 function in the developing endoderm and endothelium, we developed a dual-color temporal lineage-tracing strategy in mice combined with single-cell RNA sequencing to anal...
Yang, Yun-Sheng Liu, Man-Hua Yan, Zhao-Wen Chen, Guo-Qiang Huang, Ying
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Stem cells (Dayton, Ohio)
Mesendodermal specification and cardiac differentiation are key issues for developmental biology and heart regeneration medicine. Previously, we demonstrated that FAM122A, a highly conserved housekeeping gene, is an endogenous inhibitor of protein phosphatase 2A (PP2A) and participates in multifaceted physiological and pathological processes. Howev...
Yoshihara, Masahito Wagner, Magdalena Damdimopoulos, Anastasios Zhao, Cheng Petropoulos, Sophie Katayama, Shintaro Kere, Juha Lanner, Fredrik Damdimopoulou, Pauliina
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Stem cells (Dayton, Ohio)
Ovaries are central to development, fertility, and reproduction of women. A particularly interesting feature of ovaries is their accelerated aging compared to other tissues, leading to loss of function far before other organs senesce. The limited pool of ovarian follicles is generated before birth and once exhausted, menopause will inevitably comme...
Weng, Yun Han, Simon Sekyi, Maria T Su, Tao Mattis, Aras N Chang, Tammy T
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Stem cells (Dayton, Ohio)
Human induced pluripotent stem cell (iPSC)-derived liver organoids serve as models of organogenesis, disease, drug screening, and regenerative medicine. Prevailing methods for generating organoids rely on Matrigel, whose batch-to-batch variability and xenogeneic source pose challenges to mechanistic research and translation to human clinical therap...
Woods, Dori C Tilly, Jonathan L
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Stem cells (Dayton, Ohio)
Yoshihara, Masahito Wagner, Magdalena Damdimopoulos, Anastasios Zhao, Cheng Petropoulos, Sophie Katayama, Shintaro Kere, Juha Lanner, Fredrik Damdimopoulou, Pauliina
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Stem cells (Dayton, Ohio)
Tang, Pei-Ciao Chen, Li Singh, Sunita Groves, Andrew K Koehler, Karl R Liu, Xue Zhong Nelson, Rick F
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Stem cells (Dayton, Ohio)
The inner ear is derived from the otic placode, one of the numerous cranial sensory placodes that emerges from the pre-placodal ectoderm (PPE) along its anterior-posterior axis. However, the molecular dynamics underlying how the PPE is regionalized are poorly resolved. We used stem cell-derived organoids to investigate the effects of Wnt signaling ...
Farooqui, Naba Mohan, Arjunmohan Isik, Busra Goksu, Busra B Thaler, Roman Zhu, Xiang Yang Krier, James D Saadiq, Ishran M Ferguson, Christopher M Jordan, Kyra L
...
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Stem cells (Dayton, Ohio)
Atherosclerotic renal artery stenosis (ARAS) is associated with irreversible parenchymal renal disease and regenerative stem cell therapies may improve renal outcomes. Hypoxia preconditioning (HPC) may improve the regenerative functions of adipose tissue-derived mesenchymal stem cells (AMSC) by affecting DNA 5-hydroxymethylcytosine (5hmC) marks in ...
Zhang, Yue Zhang, Hao Xiao, Ziqiu Yuan, Guohua Yang, Guobin
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Stem cells (Dayton, Ohio)
RUNX2, an important transcriptional factor for both odontoblastic and osteoblastic differentiation, is upregulated during osteoblastic differentiation, but downregulated during late odontoblastic differentiation. However, the specific mechanism of the different RUNX2 expression in bone and dentin remains largely unknown. Importin 7 (IPO7), a member...
Jo, Young-Woo Park, Inkuk Yoo, Kyusang Woo, Hyun-Young Kim, Ye Lynne Kim, Yea-Eun Kim, Ji-Hoon Kong, Young-Yun
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Stem cells (Dayton, Ohio)
Myogenic progenitors (MPs) generate myocytes that fuse to form myofibers during skeletal muscle development while maintaining the progenitor pool, which is crucial for generating sufficient muscle. Notch signaling has been known to reserve a population of embryonic MPs during primary myogenesis by promoting cell cycle exit and suppressing premature...
