Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in t...
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Published in Stem cell reports
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in t...
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100 plus years of stem cell research-20 years of ISSCR.
Published in Stem cell reports
The International Society for Stem Cell Research (ISSCR) celebrates its 20th anniversary in 2022. This review looks back at some of the key developments in stem cell research as well as the evolution of the ISSCR as part of that field. Important discoveries from stem cell research are described, and how the improved understanding of basic stem cell...
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical transl...
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Published in Stem cell reports
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in vitro differentiation has not been performed. Here, we conduct single-cell transcriptomic profi...
Pluripotent cell states and unexpected fates.
Published in Stem cell reports
Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of human pluripotent stem cells, and how the behavior of these cells in vitro mirrors normal embryogenesis. Copyright...
2021-2022: A year in review.
Published in Stem cell reports
The need for a standard for informed consent for collection of human fetal material.
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Published in Stem cell reports
The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and overseeing the regulation of such tissue and reassure the wider community and public. Copyright © 2022 The Author(s)....
Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-d...
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Published in Stem cell reports
The generation of retinal organoids from human pluripotent stem cells (hPSC) is now a well-established process that in part recapitulates retinal development. However, hPSC-derived photoreceptors that exhibit well-organized outer segment structures have yet to be observed. To facilitate improved inherited retinal disease modeling, we determined con...
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway an...
Published in Stem cell reports
Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is accompanied by defective healing. We aimed to evaluate the role of the substance P (SP)/neurokinin-1 receptor (NK1R) pathway in corneal epithelium wound healing in a pre-clinical model of LSCD. SP ablation or NK1R blockade significantly increased epithelial woun...
Immune regulation of intestinal-stem-cell function in Drosophila.
Published in Stem cell reports
Intestinal progenitor cells integrate signals from their niche, and the gut lumen, to divide and differentiate at a rate that maintains an epithelial barrier to microbial invasion of the host interior. Despite the importance of evolutionarily conserved innate immune defenses to maintain stable host-microbe relationships, we know little about contri...
Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or or...
Published in Stem cell reports
Gametogenesis requires close interactions between germ cells and somatic cells. Derivation of sperm from spermatogonial stem cells (SSCs) is hampered by the inefficiency of spermatogonial transplantation technique in many animal species because it requires a large number of SSCs and depletion of endogenous spermatogenesis. Here we used mouse testis...
