Wen, Hao Wang, Mingjing Gong, Shiqiang Li, Xintong Meng, Jinze Wen, Jie Wang, Yifei Zhang, Shuqing Xin, Shijie
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Stem Cells and Development
Abdominal aortic aneurysm (AAA) is life-threatening, for which efficient nonsurgical treatment strategy has not been available so far. Several previous studies investigating the therapeutic effect of mesenchymal stem cells (MSCs) in AAA indicated that MSCs could inhibit aneurysmal inflammatory responses and extracellular matrix destruction, and sup...
Lim, Sai Kiang Giebel, Bernd Weiss, Daniel J. Witwer, Kenneth W. Rohde, Eva
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Stem Cells and Development
Touil, Yasmine Segaoula, Zacharie Thuru, Xavier Galiègue-Zouitina, Sylvie Tierny, Dominique Quesnel, Bruno
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Stem Cells and Development
Mucosal melanoma represents one of the most highly metastatic and aggressive subtypes of melanoma. The biology of mucosal melanoma is poorly documented, and the lack of experimental models makes it difficult to design and test new therapies. Dogs are frequently affected by melanomas of the oral cavity, making spontaneous canine melanoma a potential...
Sengupta, Vikram Sengupta, Sascha Lazo, Angel Jr. Hicok, Kevin C. Moseley, Timothy
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Stem Cells and Development
Morgan, Ben J. Bauza-Mayol, Guillermo Gardner, Oliver F. W. Zhang, Yadan Levato, Riccardo Archer, Charles W. van Weeren, Rene Malda, Jos Conlan, Robert Steven Francis, Lewis W.
...
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Stem Cells and Development
Articular cartilage contains a subpopulation of tissue-specific progenitors that are an ideal cell type for cell therapies and generating neocartilage for tissue engineering applications. However, it is unclear whether the standard chondrogenic medium using transforming growth factor beta (TGFβ) isoforms is optimal to differentiate these cells. We ...
Yang, Liu Cao, Huan Sun, Dong Lin, Ling Zheng, Wei-Ping Shen, Zhong-Yang Song, Hong-Li
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Stem Cells and Development
There is a need to improve the quality of donor liver from donation after circulatory death (DCD). The purpose of this study was to investigate the effects and mechanism of normothermic machine perfusion (NMP) combined with bone marrow mesenchymal stem cells (BMMSCs) on the oxidative stress and mitochondrial function in DCD livers. DCD livers were ...
Sengupta, Vikram Sengupta, Sascha Lazo, Angel Jr. Woods, Peter Nolan, Anna Bremer, Nicholas
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Stem Cells and Development
This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. During April 2020, ExoFlo was provided to 24 SARS-CoV-2 polymerase chain reaction-positive patients at a single hospital center, all of whom met c...
Zhao, Robert Chunhua
Published in
Stem Cells and Development
The novel coronavirus disease 2019 (COVID-19) has grown to be a global public-health emergency since patients were first detected in Wuhan, China, in December 2019. As of April 9, 2020, the novel coronavirus (named as SARS-CoV-2 by the International Committee on Taxonomy of Viruses on February 11) has infected 83,251 and 1,484,811 patients in China...
Broxmeyer, Hal E. Parker, Graham C.
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Stem Cells and Development
Ali, Gowher Elsayed, Ahmed K. Nandakumar, Manjula Bashir, Mohammed Younis, Ihab Abu Aqel, Yasmin Memon, Bushra Temanni, Ramzi Abubaker, Fadhil Taheri, Shahrad
...
Published in
Stem Cells and Development
Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes (KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular diseases. The debate on the genetic origin of psoriasis pathogenesis remains unresolved due to lack of suitable in vitro human models mimicking the disease phenot...
