Espinosa Gonzalez, Maria Volk-Draper, Lisa Bhattarai, Nihit Wilber, Andrew Ran, Sophia
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Stem Cells and Development
Myeloid-lymphatic endothelial cell progenitors (M-LECP) are a subset of bone marrow (BM)-derived cells characterized by expression of M2-type macrophage markers. We previously showed significant contribution of M-LECP to tumor lymphatic formation and metastasis in human clinical breast tumors and corresponding mouse models. Since M2 type is induced...
van Rhijn-Brouwer, Femke Christina Ching... Gremmels, Hendrik Den Ouden, Krista Teraa, Martin Fledderus, Joost Ougust Verhaar, Marianne Christina
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Stem Cells and Development
Effective treatments for chronic limb-threatening ischemia are lacking. (Pre)clinical studies on administration of bone marrow (BM) mononuclear cells (MNCs) and BM-derived mesenchymal stromal cells (MSCs) have shown variable results and no studies have directly compared administration of human BM MNCs and BM MSCs in in vivo models. We studied the e...
Lee, Olivia J Koch, Thomas G
Published in
Stem cells and development
Inflammation-associated disorders are significant causes of morbidity in horses. Equine single-donor mesenchymal stromal cells (sdMSCs) hold promise as cell-therapy candidates due to their secretory nonprogenitor functions. This has been demonstrated by mononuclear cell suppression assays (MSAs) showing that sdMSCs are blood mononuclear cell (BMC) ...
James, Victoria Nizamudeen, Zubair A. Lea, Daniel Dottorini, Tania Holmes, Terri L. Johnson, Benjamin B. Arkill, Kenton P. Denning, Chris Smith, James G.W.
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Stem Cells and Development
Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness that can lead to devastating conditions such as heart failure and sudden cardiac death. Despite extensive study, the mechanisms mediating many of the associated clinical manifestations remain unknown and human models are required. To address this, human-...
van de Vyver, Mari Boodhoo, Kiara Frazier, Trivia Hamel, Katie Kopcewicz, Marta Levi, Benjamin Maartens, Michelle Machcinska, Sylwia Nunez, Johanna Pagani, Chase
...
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Stem Cells and Development
Monitoring wound progression over time is a critical aspect for studies focused on in-depth molecular analysis or on evaluating the efficacy of potential novel therapies. Histopathological analysis of wound biopsies can provide significant insight into healing dynamics, yet there is no standardized and reproducible scoring system currently availabl...
Vaughan, Keegan L Franchini, Anthony M Kern, Harrison G Lawrence, B Paige
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Stem cells and development
The core function of hematopoietic stem and progenitor cells (HSPCs) is to provide lifelong production of all lineages of the blood and immune cells. The mechanisms that modulate HSPC homeostasis and lineage biasing are not fully understood. Growing evidence implicates the aryl hydrocarbon receptor (AHR), an environment-sensing transcription factor...
Pandya, Mirali Lyu, Huling Luan, Xianghong Diekwisch, Thomas G H
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Stem cells and development
The growth of long and polarized ameloblast-like cells has long been heralded as a major prerequisite for enamel tissue engineering. In this study, we have designed three-dimensional bioreactor/scaffold microenvironments to propagate and assess the ability of cervical loop derivatives to become long and polarized ameloblast-like cells. Our studies ...
Pardieck, Jennifer Harb, Manwal Sakiyama-Elbert, Shelly
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Stem cells and development
The ventral spinal population of V0 interneurons (INs) contributes to the coordinated movements directed by spinal central pattern generators (CPGs), including respiratory circuits and left-right alternation in locomotion. One challenge in studying V0 INs has been the limited number of cells that can be isolated from primary sources for basic resea...
Khanh, Vuong Cat Fukushige, Mizuho Chang, Yun Hsuan Hoang, Ngo Nhat Yamashita, Toshiharu Obata-Yasuoka, Mana Hamada, Hiromi Osaka, Motoo Hiramatsu, Yuji Ohneda, Osamu
...
Published in
Stem Cells and Development
Cytokine storm is recognized as one of the factors contributing to organ failures and mortality in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes mellitus (DM) or renal disease (RD) have more severe symptoms and higher mortality. However, the factors that contribute to severe outcomes of COVID-19 patients with ...
MacDonald, Julie A Woods, Dori C Tilly, Jonathan L
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Stem cells and development
Cells within tissues are routinely subjected to physiological stress and strain, arising from direct interactions with neighboring cells as well as with extracellular matrix components. Accordingly, there is tremendous interest in deciphering how cells sense, and respond to, changes in biomechanical forces. In this study, we explored the effects of...
