Cho, WonKyung J Mittal, Sharad K Chauhan, Sunil K
Published in
Stem cells translational medicine
Mounting evidence suggests mesenchymal stromal cells (MSCs) suppress CD4+ T-cell activation, but whether MSCs directly regulate activation and expansion of allogeneic T cells has not been fully deciphered. Here, we identified that both human and murine MSCs constitutively express ALCAM, a cognate ligand for CD6 receptors on T cells, and investigate...
Shaz, Beth H Kraft, Bryan D Troy, Jesse D Poehlein, Emily Chen, Lingye Cheatham, Lynn Manyara, Raha Hanafy, Khalid Brown, Linda Scott, Margaret
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Published in
Stem cells translational medicine
Treatment options for patients with COVID-19-related acute respiratory distress syndrome (ARDS) are desperately needed. Allogeneic human umbilical cord derived mesenchymal stromal cells (hCT-MSCs) have potential therapeutic benefits in these critically ill patients, but feasibility and safety data are lacking. In this phase I multisite study, 10 pa...
Loisel, Séverine Lansiaux, Pauline Rossille, Delphine Ménard, Cédric Dulong, Joëlle Monvoisin, Céline Bescher, Nadège Bézier, Isabelle Latour, Maëlle Cras, Audrey
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Published in
Stem cells translational medicine
Mesenchymal stromal cells (MSCs) have recently emerged as an interesting therapeutic approach for patients with progressive systemic sclerosis (SSc), a rare and life-threatening orphan autoimmune disease. Whereas MSC immunomodulatory potential is considered as a central mechanism for their clinical benefit, very few data are available on the impact...
Terashima, Tomoya Katagi, Miwako Ohashi, Natsuko
Published in
Stem Cells Translational Medicine
Graphical Abstract
Lin, Yifeng Li, Yaoshen Chen, Panpan Zhang, Yanye Sun, Jiwei Sun, Xiao Li, Jiaqun Jin, Jiani Xue, Jinglei Zheng, Junyan
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Published in
Stem cells translational medicine
Intrauterine adhesions (IUA), which is characterized by endometrial fibrosis, continue to be the most common cause of uterine infertility globally. Our work revealed that 3 fibrotic progression markers (Vimentin, COL5A2, and COL1A1) were significantly increased in the endometrium of IUA patients. Mesenchymal stem cell-derived exosomes (EXOs) have b...
Yamamoto, Takako Arita, Mao Tamura, Takashi Saito, Miho Katayama, Hirohito Kuroda, Hirotaka Suzuki, Takashi Kawamata, Shin
Published in
Stem Cells Translational Medicine
Graphical Abstract
Pieczonka, Katarzyna Fehlings, Michael G
Published in
Stem Cells Translational Medicine
Spinal cord injury (SCI) severely diminishes quality of life and presents patients with a substantial financial burden. The lack of a curative treatment has guided efforts toward identifying potential regenerative treatments. Neural stem/progenitor cell (NSPC) transplantation represents a promising strategy for the regeneration of the injured spina...
Motta, Sarah E Martin, Marcy Gähwiler, Eric K N Visser, Valery L Zaytseva, Polina Ehterami, Arian Hoerstrup, Simon P Emmert, Maximilian Y
Published in
Stem cells translational medicine
Cardiovascular disease is a major cause of morbidity and mortality worldwide and, to date, the clinically available prostheses still present several limitations. The design of next-generation regenerative replacements either based on cellular or extracellular matrix technologies can address these shortcomings. Therefore, tissue engineered construct...
Anbazhagan, Murugadas Geem, Duke Venkateswaran, Suresh Pelia, Ranjit Kolachala, Vasantha L Dodd, Anne Maddipatla, Sushma C Cutler, David J Matthews, Jason D Chinnadurai, Raghavan
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Published in
Stem cells translational medicine
Therapy with mesenchymal stromal cells (MSCs) has shown promise in inflammatory bowel disease-leveraging their immunosuppressive and regenerative properties. However, the potential immunogenic complications of allogenic MSCs sourced from different tissues raise concern. Thus, we assessed the fitness and functionality of autologous intestinal MSCs a...
Purcell, Elisha Nguyen, Timothy Smith, Madeleine Penny, Tayla Paton, Madison C B Zhou, Lindsay Jenkin, Graham Miller, Suzanne L McDonald, Courtney A Malhotra, Atul
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Published in
Stem Cells Translational Medicine
Graphical Abstract
