Domdey, M. Kluth, M.A. Maßlo, C. Ganss, C. Frank, M.H. Frank, N.Y. Coroneo, M.T. Cursiefen, C. Notara, M.
Published in
Stem Cell Research
Pterygium pathogenesis is often attributed to a population of altered limbal stem cells, which initiate corneal invasion and drive the hyperproliferation and fibrosis associated with the disease. These cells are thought to undergo epithelial to mesenchymal transition (EMT) and to contribute to subepithelial stromal fibrosis. In this study, the pres...
Philip Creamer, J. Luff, Stephanie A. Yu, Hao Sturgeon, Christopher M.
Published in
Stem Cell Research
To achieve efficient, reproducible differentiation of human pluripotent stem cells (hPSCs) towards specific hematopoietic cell-types, a comprehensive understanding of the necessary cell signaling and developmental trajectories involved is required. Previous studies have identified the mesodermal progenitors of extra-embryonic-like and intra-embryon...
Simons, Eline Nijak, Aleksandra Loeys, Bart Alaerts, Maaike
Published in
Stem cell research
Brugada syndrome (BrS) is an inherited primary electrical disorder of the heart. 25% of BrS patients carry a mutation in the SCN5A gene, encoding the cardiac specific voltage-gated sodium channel Nav1.5. Here we report two iPSC lines (BBANTWi006-A, BBANTWi007-A) of a brother and a sister carrying an SCN5A mutation (c.4813 + 3_4813 + 6dupGGGT) causi...
Romano, Elena Trionfini, Piera Giampietro, Roberta Benigni, Ariela Tomasoni, Susanna
Published in
Stem cell research
Human induced pluripotent stem cells (iPSCs) have great promise in regenerative medicine. However, several limitations, including immune-incompatibility, have raised concerns regarding their clinical application. Recent studies have shown that human iPSCs and their derivatives lose their immunogenicity when major histocompatibility complex (MHC) cl...
Li, Xiajun Li, Albert Jiarui Du, Bin
Published in
Stem Cell Research
Pakzad, Khadijeh Kathy Tan, Jun Jie Anderson, Stephanie Board, Mary Clarke, Kieran Carr, Carolyn A.
Published in
Stem Cell Research
Cardiosphere-derived cells (CDCs) can be expanded in vitro and induced to differentiate along the cardiac lineage. To recapitulate the phenotype of an adult cardiomyocyte, differentiating progenitors need to upregulate mitochondrial glucose and fatty acid oxidation. Here we cultured and differentiated CDCs using protocols aimed to maintain stemness...
Pedrosa, Carolina da S G Goto-Silva, Livia Temerozo, Jairo R Souza, Leticia R Q Vitória, Gabriela Ornelas, Isis M Karmirian, Karina Mendes, Mayara A Gomes, Ismael C Sacramento, Carolina Q
...
Published in
Stem cell research
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential ...
Sarkar, Hajrah Méjécase, Cécile Harding, Philippa Eintracht, Jonathan Toualbi, Lyes Cunha, Dulce Lima Moosajee, Mariya
Published in
Stem cell research
Induced pluripotent stem cell (iPSC) lines were generated from two patients with RDH12 variants. UCLi014-A is from a patient with heterozygous frameshift mutation c.759del p.(Phe254Leufs*24), associated with autosomal dominant retinitis pigmentosa. UCLi015-A is from a patient with homozygous missense mutation c.619A > G p.(Asn207Asp), associated wi...
Giani, Alice Maria Chen, Shuibing
Published in
Stem cell research
The coronavirus disease 2019 (COVID-19) global pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over 200 countries and territories worldwide and resulted in more than 2.5 million deaths. In a pressing search for treatments and vaccines, research models based on human stem cells are emerging as c...
Wu, Feima Chen, Yan You, Kai Tan, Shenglin Xu, Yingying Wang, Pei-Hui Liu, Shiming Li, Yin-Xiong
Published in
Stem cell research
Excessive prostaglandin E2 (PGE2) is the key pathological basis for COVID-19 and a Celebrex treatment of hospitalized COVID-19 patients with comorbidities led to 100% discharged rate and zero death (Hong et al. 2020). It is also suggested that SARS-CoV-2 infected multiple organs and the SARS-CoV nucleocapsid (N) protein transcriptionally drives the...
