Published in Stem Cell Reports
In this article, Master, Matthews, and Abou-el-Enein argue that the World Health Organization (WHO) should establish an Expert Advisory Committee on Regenerative Medicine to address the global problem of clinics selling unproven stem cell interventions (SCIs). The WHO committee can develop harmonized standards, promote responsible access to cell-ba...
Published in Stem Cell Reports
Published in Stem Cell Reports
In this article, Lutolf and colleagues propose a new method to study post-implantation embryonic development in vitro. Aggregates of mouse embryonic stem cells were shown to differentiate into structures with embryo-like patterning and morphogenesis. Furthermore, initial aggregate size and inhibition of Wnt signaling has been shown to be crucial fo...
Published in Stem Cell Reports
In this review, Lutolf and coworkers discuss how bioengineering approaches can further advance the optimization and external control of stem cell-based embryo-like structures. In vitro models of embryonic development combined with sophisticated bioengineering tools will enable an even more in-depth analysis of embryonic development in the future.
Published in Stem Cell Reports
A novel modulatory gene PHOX2B decreased in human iPSC-derived MNs with TARDBP mutations and PHOX2B knockdown reduced neurite length and impaired motor functions in vivo and vitro . PHOX2B is known that highly express in other type of neurons maintained after the progression of ALS. Collectively, TARDBP mutations induced loss of axonal resilience,...
Published in Stem Cell Reports
The ISSCR’s revised Guidelines for Stem Cell Research and Clinical Translation reflect the organization’s commitment to opposing premature commercialization of stem cell-based interventions and supporting the development of products that meet stringent ethical, scientific, and regulatory standards. The Guidelines contain five important new recommen...
Published in Stem Cell Reports
The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryo...
Published in Stem Cell Reports
In this perspective, Rossant, Clark, and colleagues outline the process and deliberations that led to the updated ISSCR Guidelines for stem cell research involving the 14-Day rule, stem cell-based embryo models, and in vitro gametogenesis.
Published in Stem Cell Reports
The updated Guidelines for Stem Cell Research and Clinical Translation describe the ethical principles and best practices for basic, translational, and clinical research involving stem cells and human embryos. The updated Guidelines include new recommendations to address the recent scientific advances involving embryos, stem cell-based embryo model...
Published in Stem Cell Reports
In this article, Okarmus and colleagues show that loss-of-function mutations in the PARK2 gene (parkin) leads to metabolic dysregulation. Changes in the metabolome of human iPSC-derived neurons with such mutations were accompanied by altered mitochondrial and energy homeostasis, increased oxidative stress, and a reduced anti-oxidative response. The...
