Published in Stem Cell Reports
In this review article, Costa et al. discuss the role of “basal-like” intrapulmonary p63+ progenitor cells in regeneration/remodeling after severe lung injury, especially that caused by respiratory viruses. This repair mechanism serves to aid in restoration of epithelial barrier function but ultimately generates bronchiolar cell types in the alveol...
Published in Stem Cell Reports
In this study, Fico, Beclin, and colleagues show that the long non-coding RNA T-UCstem1 is expressed in the forebrain neurogenic lineage generating interneurons for the postnatal olfactory bulb. Increased T-UCstem1 levels in neural stem cells induced progenitor proliferation at the expense of neuron production, whereas its downregulation caused the...
Published in Stem Cell Reports
In this article, Mannhardt and colleagues show that a systematic evaluation of 10 control hPSC-CM lines (commercial and academic) revealed high levels of variability regarding baseline contractility between the lines. In contrast, inotropic drug effects showed less prominent variability in canonical responses, arguing for a smaller relevance in dru...
Published in Stem Cell Reports
In this article, Yang and colleagues revealed features of m6A modification in Sertoli cells and showed that WTAP deficiency causes dysregulated transcripts encoding spermatogonial stem cell (SSC) niche factors and the progressive loss of SSCs. They conclude that WTAP-mediated m6A in Sertoli cell is indispensable for sustaining SSC niche.
Published in Stem Cell Reports
In this report, Crane and colleagues report findings on US public attitudes toward human-animal chimeric embryo research. A majority of survey respondents personally accept the process of injecting human stem cells into genetically modified swine embryos and transplanting human tissues produced in a pig's body. Strong public support should compel t...
Published in Stem Cell Reports
This study sought to determine whether there is a common glial precursor cell (GPC), what the GPC markers are, and what molecular mechanisms govern gliogenesis. Takeuchi and colleagues identified the RNA-binding protein Qk as a GPC marker. Functional analysis revealed that Qk comprehensively upregulates essential genes for gliogenesis and that loss...
Published in Stem Cell Reports
In this study, Sumer, Hoffmann, et al., developed a strategy for the isolation of extremely rare hiPSC clones, suitable for scarless correction of heterozygous mutations by random enrichment of precisely edited cells and their detection via allele quantification. This strategy facilitates hiPSC-based gene correction regardless of the gene-editing a...
Published in Stem Cell Reports
In this article, Shaker and colleagues show that cell-cell adhesion and cell-migration properties of the NPCs in the elongating embryonic spinal cord were different depending on their anteroposterior position (anterior
Published in Stem Cell Reports
Cerebral organoids (COs) have a unique advantage in modeling human-specific features of early brain development. Here, we profile their neuroelectrical activities with an MEA platform over time and correlate these activities with their increasingly complex molecular and cellular features. This integrated approach highlights the value of COs as an e...
Published in Stem Cell Reports
In this article, Parmar and colleagues show proof of concept that human glial progenitors (hGPCs) sourced from fetal brains can be converted into functional neurons. To allow for large-scale studies, a stem cell-based model system that mimics the fetal cell conversion was established and used to identify optimal combinations of fate determinants fo...
