Cao, Miao Su, Xiaojie Jiang, Shibo
Published in
Stem Cell Reports
In this article, Jiang and colleagues describe advances and challenges in the development of broad-spectrum vaccines and neutralizing antibodies against lineage B betacoronaviruses (β-CoV-Bs), including SARS-CoV-2, SARS-CoV, and SARSr-CoV, and peptide-based pan-CoV fusion inhibitors, and discuss their potential in the prevention and treatment of CO...
Geurts, Maarten H. van der Vaart, Jelte Beumer, Joep Clevers, Hans
Published in
Stem Cell Reports
In this work Beumer, Clevers, and colleagues review the current state of affairs of ASC- and iPSC-derived organoids in fighting the current SARS-CoV-2 pandemic. To limit the impact of this pandemic, rapid scientific insights are crucial. Organoids closely resemble human physiology, and are emerging for studying viral biology and to identify potenti...
Dobrindt, Kristina Hoagland, Daisy A. Seah, Carina Kassim, Bibi O'Shea, Callan P. Murphy, Aleta Iskhakova, Marina Fernando, Michael B. Powell, Samuel K. Deans, P.J. Michael
...
Published in
Stem Cell Reports
Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro .
Marchiano, Silvia Hsiang, Tien-Ying Khanna, Akshita Higashi, Ty Whitmore, Leanne S. Bargehr, Johannes Davaapil, Hongorzul Chang, Jean Smith, Elise Ong, Lay Ping
...
Published in
Stem Cell Reports
In this article, Marchiano and colleagues show that SARS-CoV-2 can infect human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), where it replicates to high copy number, significantly impairs electrical and mechanical functions, and eventually causes cell death. This supports the hypothesis that cardiac disease can result from direct infect...
Tiwari, Shashi Kant Wang, Shaobo Smith, Davey Carlin, Aaron F. Rana, Tariq M.
Published in
Stem Cell Reports
In this report, Rana and colleagues show that human iPSC-derived lung and brain organoids express ACE2/TMPRSS2 and are permissive to SARS-CoV-2 infection inducing specific pathways in lung and brain cells. Spike protein inhibitor, EK1 peptide, and TMPRSS2 inhibitors (camostat/nafamostat) reduced SARS-CoV-2 infection in lung organoids, providing a m...
Ramani, Anand Pranty, Abida-Islam Gopalakrishnan, Jay
Published in
Stem Cell Reports
Jay Gopalakrishnan and colleagues have summarized the neuroinvasive potential of SARS-CoV-2 using human brain organoids as a model system. The report features the possibility of bioengineered brain organoids supporting the productive replication of the virus. Subsequently, the authors discuss how the brain organoids can identify agents that can mit...
Bolo, Isabel Wills, Ben Curran Maschke, Karen J.
Published in
Stem Cell Reports
Crane, Andrew T. Shen, Francis X. Low, Walter C.
Published in
Stem Cell Reports
Wang, Xiaofang Kimbrel, Erin A. Ijichi, Kumiko Paul, Debayon Lazorchak, Adam S. Chu, Jianlin Kouris, Nicholas A. Yavanian, Gregory J. Lu, Shi-Jiang Pachter, Joel S.
...
Published in
Stem Cell Reports
Huerga Encabo, Hector Grey, William Garcia-Albornoz, Manuel Wood, Henry Ulferts, Rachel Aramburu, Iker Valle Kulasekararaj, Austin G. Mufti, Ghulam Papayannopoulos, Venizelos Beale, Rupert
...
Published in
Stem Cell Reports
H. Huerga Encabo and colleagues demonstrate that SARS-CoV-2 can infect erythroid progenitors without impairing their functionality, rather causing an expansion of colonies where the virus can be detected. These findings shed light into the patients with severe COVID-19 who suffer from an aberrant increase of nucleated red blood cells concomitant wi...
