Published in Stem Cell Reports
Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro .
Published in Stem Cell Reports
In this article, Marchiano and colleague show that SARS-CoV-2 can infect human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), where it replicates to high copy number, significantly impairs electrical and mechanical functions, and eventually causes cell death. This supports the hypothesis that cardiac disease can result from direct infecti...
Published in Stem Cell Reports
In this report, Rana and colleagues show that human iPSC-derived lung and brain organoids express ACE2/TMPRSS2 and are permissive to SARS-CoV-2 infection inducing specific pathways in lung and brain cells. Spike protein inhibitor, EK1 peptide, and TMPRSS2 inhibitors (camostat/nafamostat) reduced SARS-CoV-2 infection in lung organoids providing a mo...
Published in Stem Cell Reports
Jay Gopalakrishnan and colleagues have summarized the neuroinvasive potential of SARS-CoV-2 using human brain organoids as a model system. The report features the possibility of bioengineered brain organoids supporting the productive replication of the virus. Subsequently, the authors discuss how the brain organoids can identify agents that can mit...
Published in Stem Cell Reports
Published in Stem Cell Reports
Published in Stem Cell Reports
Published in Stem Cell Reports
H. Huerga Encabo and colleagues demonstrate that SARS-CoV-2 can infect erythroid progenitors without impairing their functionality, rather causing an expansion of colonies where the virus can be detected. These findings shed light into the patients with severe COVID-19 who suffer from an aberrant increase of nucleated red blood cells concomitant wi...
Published in Stem Cell Reports
In this article, Swaroop and colleagues show impaired expression of opsin visual pigments in retinal organoids derived from iPSC lines of patients with Leber congenital amaurosis, caused by dominant mutations in the photoreceptor transcription factor gene CRX . AAV-mediated CRX gene augmentation partially restores the expression of phototransductio...
Published in Stem Cell Reports
We established a culture procedure to generate hiPSC-derived enterocyte-like cells that can be used as a model for the evaluation of drug transport and metabolism studies in the human small intestine.
