Published in Stem Cell Reports
In the event that human embryo genome editing is considered safe enough for the clinic, researchers will need to consider how to administer consent so that would-be recipients of edited embryos can make an informed decision. Informed consent will require truthfulness, sensitivity, regulatory compliance, and attention to the highest ethical standard...
Published in Stem Cell Reports
In this article, Dan Garry and colleagues highlight important ethical issues that accompany the use of emerging technologies such as blastocyst complementation, somatic cell nuclear transfer, and gene-edited hiPSCs to produce humanized vasculature and blood in a pig. These ethical issues require open discussion to promote public trust.
Published in Stem Cell Reports
In this article, Saghatelyan and colleagues show that olfactory epithelium-derived neural stem cells adapt their developmental program in response to heterotopic neurogenic niche factors after grafting in vivo . They migrate and differentiate into ectopic brain region neurons that are indistinguishable in their morpho-functional properties from end...
Published in Stem Cell Reports
Separating the HSC population by divisional history shows patterned expression changes across the divisional history spectrum indicating that lineage priming and differentiation are functions of cell divisions themselves. Comparative analysis of gene expression, chromatin, and knockout studies reveal that an epigenetic switch from Ezh1 to Ezh2 unde...
Published in Stem Cell Reports
In this article, Vankelecom and colleagues developed a well-defined protocol to establish organoid cultures from ovarian cancer (OC), particularly from the prevalent high-grade serous OC. The organoids capture disease hallmarks and patient tumor characteristics and provide powerful experimental models to decipher the cancer's pathobiology (such as ...
Published in Stem Cell Reports
Cowan and colleagues have demonstrated the expression of mitoregulin ( MTLN ) in murine adipose tissue as well as human stem cell-derived adipocytes. MTLN affects triglyceride accumulation and lipolysis in adipocytes. It does so through mitochondrial localization and interaction with complexes involved in fatty acid oxidation.
Published in Stem Cell Reports
In this article, Temple, Blenkinsop, and colleagues characterize retinal pigment epithelium (RPE) EMT both transcriptionally and epigenetically in a model of PVR and found a gene signature that predicted the inhibitory effect of nicotinamide on both RPE contractility and EMT.
Published in Stem Cell Reports
In this article, Hartman and colleagues show that, depending on the specific cells in which it is expressed, Yes-associated protein (YAP) exhibits opposing effects on pluripotency induction from mouse somatic cells. Specifically, YAP inhibits pluripotency induction cell-autonomously but promotes it non-cell-autonomously. Its non-autonomous function...
Published in Stem Cell Reports
Published in Stem Cell Reports
To critically evaluate NF1 mutational equivalency in human brain cells, Anastasaki and colleagues generated an isogenic series of seven human induced pluripotent stem cell lines harboring different NF1 patient NF1 mutations. Although all mutations increased 2D NPC and astrocyte RAS activity and cell proliferation, distinct NF1 mutations had differe...
