Petrus-Reurer, Sandra Lederer, Alex R Baqué-Vidal, Laura Douagi, Iyadh Pannagel, Belinda Khven, Irina Aronsson, Monica Bartuma, Hammurabi Wagner, Magdalena Wrona, Andreas
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Published in
Stem cell reports
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in vitro differentiation has not been performed. Here, we conduct single-cell transcriptomic profi...
Jackson, Robert M. Hatton, Catherine F. Spegarova, Jarmila Stremenova Georgiou, Maria Collin, Joseph Stephenson, Emily Verdon, Bernard Haq, Iram J. Hussain, Rafiqul Coxhead, Jonathan M.
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Published in
Stem Cell Reports
In this article, Lako and colleagues generated an air-liquid-interface in vitro model of human conjunctival cells comprising all the epithelial cell types found in the native conjunctiva. Infection of the model with SARS-CoV-2 shows that while all conjunctival cells can be infected with the virus, new viral particles that are necessary for propagat...
Li, Sanming Tang, Liying Zhou, Jing Anchouche, Sonia Li, Dian Yang, Yiran Liu, Zhaolin Wu, Jieli Hu, Jiaoyue Zhou, Yueping
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Published in
Stem cell reports
Lendahl, Urban
Published in
Stem cell reports
The International Society for Stem Cell Research (ISSCR) celebrates its 20th anniversary in 2022. This review looks back at some of the key developments in stem cell research as well as the evolution of the ISSCR as part of that field. Important discoveries from stem cell research are described, and how the improved understanding of basic stem cell...
Pera, Martin F
Published in
Stem cell reports
Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of human pluripotent stem cells, and how the behavior of these cells in vitro mirrors normal embryogenesis. Copyright...
Fernando, Milan Lee, Scott Wark, Jesse R Xiao, Di Lim, Benjamin Y O'Hara-Wright, Michelle Kim, Hani J Smith, Grady C Wong, Ted Teber, Erdahl T
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Published in
Stem cell reports
Advances in the study of neurological conditions have been possible because of pluripotent stem cell technologies and organoids. Studies have described the generation of neural ectoderm-derived retinal and brain structures from pluripotent stem cells. However, the field is still troubled by technical challenges, including high culture costs and var...
Little, Melissa
Published in
Stem cell reports
Barker, Roger A Boer, Gerard J Cattaneo, Elena Charo, R Alta Chuva de Sousa Lopes, Susana M Cong, Yali Fujita, Misao Goldman, Steven Hermerén, Göran Hyun, Insoo
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Published in
Stem cell reports
The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and overseeing the regulation of such tissue and reassure the wider community and public. Copyright © 2022 The Author(s)....
Chitiashvili, Tsotne Hsu, Fei-Man Dror, Iris Plath, Kathrin Clark, Amander
Published in
Stem cell reports
Human germ cell development is a highly regulated process beginning soon after embryo implantation with the specification of primordial germ cells (PGCs) and ending in adulthood with the differentiation of gametes. Here, we show that fibroblast growth factor receptor 3 (FGFR3) is expressed by human PGCs during the first and second trimester, becomi...
Kenkhuis, Boyd van Eekeren, Michelle Parfitt, David A Ariyurek, Yavuz Banerjee, Poulomi Priller, Josef van der Weerd, Louise van Roon-Mom, Willeke M C
Published in
Stem cell reports
Iron accumulation in microglia has been observed in Alzheimer's disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms, including neuroinflammation. To study this interaction, we treated human induced pluripotent stem cell-derived microglia (iPSC-MG) with iron, in combination wit...
