Response to letter by Antonio Martín Andrés on "A boundary-optimized rejection region test for the two-sample binomial p...
Published in Statistics in medicine
Comments on "A boundary-optimized rejection region test for the two-sample binomial problem".
Published in Statistics in medicine
An efficient and robust method for analyzing population pharmacokinetic data in genome-wide pharmacogenomic studies: a g...
Published in Statistics in medicine
Powerful array-based single-nucleotide polymorphism-typing platforms have recently heralded a new era in which genome-wide studies are conducted with increasing frequency. A genetic polymorphism associated with population pharmacokinetics (PK) is typically analyzed using nonlinear mixed-effect models (NLMM). Applying NLMM to large-scale data, such ...
Improving likelihood-based inference in control rate regression.
Published in Statistics in medicine
Control rate regression is a diffuse approach to account for heterogeneity among studies in meta-analysis by including information about the outcome risk of patients in the control condition. Correcting for the presence of measurement error affecting risk information in the treated and in the control group has been recognized as a necessary step to...
A Bayesian approach for analyzing zero-inflated clustered count data with dispersion.
Published in Statistics in medicine
In practice, count data may exhibit varying dispersion patterns and excessive zero values; additionally, they may appear in groups or clusters sharing a common source of variation. We present a novel Bayesian approach for analyzing such data. To model these features, we combine the Conway-Maxwell-Poisson distribution, which allows both overdispersi...
A threshold-free summary index of prediction accuracy for censored time to event data.
Published in Statistics in medicine
Prediction performance of a risk scoring system needs to be carefully assessed before its adoption in clinical practice. Clinical preventive care often uses risk scores to screen asymptomatic population. The primary clinical interest is to predict the risk of having an event by a prespecified future time t0 . Accuracy measures such as positive pred...
A review of tensor-based methods and their application to hospital care data.
Published in Statistics in medicine
In many situations, a researcher is interested in the analysis of the scores of a set of observation units on a set of variables. However, in medicine, it is very frequent that the information is replicated at different occasions. The occasions can be time-varying or refer to different conditions. In such cases, the data can be stored in a 3-way ar...
Circular-circular regression model with a spike at zero.
Published in Statistics in medicine
With reference to a real data on cataract surgery, we discuss the problem of zero-inflated circular-circular regression when both covariate and response are circular random variables and a large proportion of the responses are zeros. The regression model is proposed, and the estimation procedure for the parameters is discussed. Some relevant test p...
Efficient treatment allocation in 2 × 2 multicenter trials when costs and variances are heterogeneous.
Published in Statistics in medicine
At the design stage of a study, it is crucial to compute the sample size needed for treatment effect estimation with maximum precision and power. The optimal design depends on the costs, which may be known at the design stage, and on the outcome variances, which are unknown. A balanced design, optimal for homogeneous costs and variances, is typical...
Semiparametric accelerated failure time cure rate mixture models with competing risks.
Published in Statistics in medicine
Modern medical treatments have substantially improved survival rates for many chronic diseases and have generated considerable interest in developing cure fraction models for survival data with a non-ignorable cured proportion. Statistical analysis of such data may be further complicated by competing risks that involve multiple types of endpoints. ...
