Phase advance of bedtimes in Alzheimer's disease.
Published in Sleep
Use of extended reality in sleep health, medicine, and research: a scoping review.
Published in Sleep
This scoping review explores the use of extended reality (virtual, augmented, and mixed reality) within sleep health, sleep medicine, and sleep research. It aims to provide insight into current uses and implementation considerations whilst highlighting directions for future research. A systematic scoping review was undertaken informed by the prefer...
Association between circadian sleep regulation and cortical gyrification in young and older adults.
...Published in Sleep
The circadian system orchestrates sleep timing and structure and is altered with increasing age. Sleep propensity, and particularly REM sleep is under strong circadian control and has been suggested to play an important role in brain plasticity. In this exploratory study, we assessed whether surface-based brain morphometry indices are associated wi...
Stimulating hypocretin receptors improves sleepiness and vigilance in idiopathic hypersomnia: lessons from a proof of co...
Published in Sleep
Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents.
...Published in Sleep
Adolescence is characterized by significant brain development, accompanied by changes in sleep timing and architecture. It also is a period of profound psychosocial changes, including the initiation of alcohol use; however, it is unknown how alcohol use affects sleep architecture in the context of adolescent development. We tracked developmental ch...
Safety and pharmacodynamics of a single infusion of danavorexton in adults with idiopathic hypersomnia.
Published in Sleep
Idiopathic hypersomnia (IH) is a chronic disorder characterized by excessive daytime sleepiness unexplained by another disorder or drug/medication use. Although the orexin system plays a role in sleep-wake regulation, orexin A levels in the cerebrospinal fluid are normal in people with IH. This phase 1b, randomized, placebo-controlled, crossover st...
Sleep of mothers, fathers, and infants: a longitudinal study from pregnancy through 12 months.
Published in Sleep
This study assessed and compared mothers' and fathers' sleep trajectories from pregnancy and throughout the first year of the infant's life. We also examined associations between maternal, paternal, and infant sleep. Two hundred and thirty-two couples were recruited for the study during pregnancy. Data were collected during pregnancy and at 4, 8, a...
Sleep behavior traits and associations with opioid-related adverse events: a cohort study.
...Published in Sleep
Opioid-related adverse events (OAEs), including opioid use disorders, overdose, and death, are serious public health concerns. OAEs are often associated with disrupted sleep, but the long-term relationship between poor sleep and subsequent OAE risk remains unknown. This study investigates whether sleep behavior traits are associated with incident O...
Quantitative measurement of motor activity during sleep in isolated REM sleep behavior disorder patients using actigraph...
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Published in Sleep
We conducted a prospective study to quantify motor activity during sleep measured by actigraphy before and after 3 months of treatment with clonazepam in patients with video-polysomnography (vPSG) confirmed isolated rapid eye movement (REM) sleep behavior disorder (iRBD). The motor activity amount (MAA) and the motor activity block (MAB) during sle...
Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons.
Published in Sleep
Long-term use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate [GHB]) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and long-term opiate administration to mice significantly increased the number of detected hypocretin/orexin (Hcrt) neurons, decreased their size, a...
