Lubda, Markus Zander, Maximilian Salazar, Andrew Kolmar, Harald von Hagen, Jörg
Published in
Skin Pharmacology and Physiology
Introduction: The skin is a major physical barrier to the environment, and thus, percutaneous delivery of active ingredients to the dermal target site faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically. Objective...
Yang, Kyungmi Park, Won Cho, Juhee Kang, Danbee Choi, Doo Ho Kim, Haeyoung Cho, Won Kyung Park, Hyeokgon Kim, Eunjoo
Published in
Skin Pharmacology and Physiology
Background: There has been few research on how to measure skin status quantitatively throughout the course of radiotherapy (RT). We evaluated the changes in the skin induced by 2 different RT techniques using objective measurements in breast cancer patients. Methods: In this prospective study, between August 2015 and March 2019, serial measurements...
Huang, Jiayi Cui, Yahua Yang, Yanling Li, Huahua Zhang, Yi Yang, Haiju Du, Shouying Bai, Jie
Published in
Skin Pharmacology and Physiology
Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP...
Ogunjimi, Abayomi Tolulope Lawson, Christine Carr, Jamie Patel, Krishna Kumar Ferguson, Nkanyezi Brogden, Nicole K.
Published in
Skin Pharmacology and Physiology
Introduction: The continuous availability of open micropores is crucial for a successful microneedle (MN) drug delivery strategy. However, micropore lifetime depends on intrinsic skin functional and anatomical characteristics, which vary significantly at different anatomical sites. Objective: This pilot study explored if differences exist in microp...
Wu, Yun Cao, Kun Zhang, Wei Zhang, Guangxian Zhou, Maojun
Published in
Skin Pharmacology and Physiology
Skin aging usually leads to the excessive deterioration of the dermal extracellular matrix, loss of antimicrobial function, loss of skin barrier function, and a series of inflammatory processes. Bioactive peptides have been widely used in cosmetics due to their protective effects on skin and efficient absorption. Combination of different peptides m...
Rathner, Adriana Rathner, Petr Friedrich, Andreas Wießner, Michael Kitzler, Christian Manuel Schernthaner, Jan Karl, Thomas Krauß, Jan Lottspeich, Friedrich Mewes, Werner
...
Published in
Skin Pharmacology and Physiology
Introduction: Epidermolysis bullosa (EB) describes a family of rare genetic blistering skin disorders. Various subtypes are clinically and genetically heterogeneous, and a lethal postpartum form of EB is the generalized severe junctional EB (gs-JEB). gs-JEB is mainly caused by premature termination codon (PTC) mutations in the skin anchor protein L...
Wilson, Thad E. Narra, Seetharam Metzler-Wilson, Kristen Schneider, Artur Bullens, Kelsey A. Holt, Ian S.
Published in
Skin Pharmacology and Physiology
Bradykinin increases skin blood flow via a cGMP mechanism but its role in sweating in vivo is unclear. There is a current need to translate cell culture and nonhuman paw pad studies into in vivo human preparations to test for therapeutic viability for disorders affecting sweat glands. Protocol 1: physiological sweating was induced in 10 healthy sub...
Bai, Taoping Jiang, Wentao Liang, Lin Li, Yalan Fan, Yubo
Published in
Skin Pharmacology and Physiology
Objectives: The objective of our study was to develop an optical method that instantly evaluates the stability of sclerosing foam, which would enable early predictions of the clinical performance of the foam and reduce the occurrence of clinical side effects. Methods: Based on the principle of light scattering, we developed a method to optically te...
Zhao, Hua Wu, Jinhao Wang, Nan Grether-Beck, Susanne Krutmann, Jean Wei, Liu
Published in
Skin Pharmacology and Physiology
Background: Oral supplementation with a standardized extract from the bark of the French pine (Pycnogenol®) has been reported to benefit the skin. It might thus represent an easy-to-use strategy to improve the skin health of individuals who are exposed to considerable environmental stress in large urban areas. Objective: We investigated if oral int...
Évora, Ana S. Adams, Michael J. Johnson, Simon A. Zhang, Zhibing
Published in
Skin Pharmacology and Physiology
Background: Skin is the interface between an organism and the external environment, and hence the stratum corneum (SC) is the first to withstand mechanical insults that, in certain conditions, may lead to integrity loss and the development of pressure ulcers. The SC comprises corneocytes, which are vital elements to its barrier function. These cell...
