Published in Skin Pharmacology and Physiology
Introduction: Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. Objective: We investigated the link between flare and itch using 3 models of itch. Methods: Skin provocations with histamine, capsaicin, and cowhage were performed in 31 subje...
Published in Skin Pharmacology and Physiology
Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of ant...
Published in Skin Pharmacology and Physiology
Skin cancer is the most common cancer worldwide, with rapidly increasing incidence and consistent mortality. Skin cancer encompasses melanoma and non-melanoma skin cancer, which in turn is mainly divided into cutaneous squamous cell carcinoma and basal cell carcinoma. Small noncoding microRNAs (miRNAs) regulate protein expression after transcripti...
Published in Skin Pharmacology and Physiology
Background: The use of antioxidants has become a common practice in the development of antiaging cosmetics. Objective: The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants. Method: Thirty-six healthy women from 32 to 65 years were enrolled in this study. The study was ca...
Published in Skin Pharmacology and Physiology
Background: The pharmacological study of mechanoreceptors embedded within tissue is hampered by tissue barriers to applied research drugs. Methods: Hyaluronidase increases the permeability of tissues and is used clinically to facilitate the distribution of injected drugs. An in vitro rat sinus hair preparation was used to determine whether hyaluron...
Published in Skin Pharmacology and Physiology
The dermal papilla comprises mesenchymal cells in hair follicles, which play the main role in regulating hair growth. Maintaining the potential hair inductivity of dermal papilla cells (DPCs) and dermal sheath cells during cell culture is the main factor in in vitro morphogenesis and regeneration of hair follicles. Using common methods for the cult...
Published in Skin Pharmacology and Physiology
Background: The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. Objectives: This work presents the contributions of the lipid...
Published in Skin Pharmacology and Physiology
Background: Janus kinases (JAKs) are a family of non-receptor protein tyrosine kinases that are expressed in a variety of tissues. Several JAK-controlled cytokine receptor pathways are incriminated in the initiation and progression of psoriasis. Genetic polymorphisms influencing JAK expression would be anticipated to have a great impact on disease ...
Published in Skin Pharmacology and Physiology
Objective: The skin acts as a mechanical and protective barrier against viral, fungal, and bacterial infections. Skin conditions such as atopic dermatitis and psoriasis are characterized by alterations of the skin barrier, often caused by injury and by bacterial infections. In the last years, non-pharmacological interventions have gained great impo...
Published in Skin Pharmacology and Physiology
Introduction: Hyaluronan (HA) is a major component of the skin that exerts a variety of biological functions. Inter-α-trypsin inhibitor heavy chain (ITIH) proteins comprise a family of hyaladherins of which ITIH5 has recently been described in skin, where it plays a functional role in skin morphology and inflammatory skin diseases including allergi...
