Chaudhari, Mamata Zelko, Igor Lorkiewicz, Pawel Hoetker, David Nong, Yibing Doelling, Benjamin Brittian, Kenneth Bhatnagar, Aruni Srivastava, Sanjay Baba, Shahid P
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Published in
Skeletal muscle
Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in the pathogenesis of muscle wasting. Oxidative stress leads to the formation of toxic lipid peroxidation products, such as 4-hydroxy-2-nonenal (HNE), which covalently bind with proteins and DNA and activate atrophic pathways. Wheth...
Nguyen, Thuy-Hang Paprzycki, Lise Legrand, Alexandre Declèves, Anne-Emilie Heher, Philipp Limpens, Maelle Belayew, Alexandra Banerji, Christopher R S Zammit, Peter S Tassin, Alexandra
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Published in
Skeletal muscle
Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic response pathway is of particular interest in patients with hereditary muscular dystrophies since many present respiratory impairment and mus...
Lambert, Matthias R Gussoni, Emanuela
Published in
Skeletal muscle
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction in slow muscle fibers. Recent advances suggest that TPM3 isoforms hold more extensive functions during skeletal muscle development and in ...
Burton, Mark A Garratt, Emma S Hewitt, Matthew O Sharkh, Hanan Y Antoun, Elie Westbury, Leo D Dennison, Elaine M Harvey, Nicholas C Cooper, Cyrus MacIsaac, Julia L
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Published in
Skeletal muscle
While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigenetic processes are suggested to contribute to the development of ageing-associated diseases, we investigated whether diff...
Lorena, Marcelo Dos Santos Voltani Santos, Estela Kato Dos Ferretti, Renato Nagana Gowda, G A Odom, Guy L Chamberlain, Jeffrey S Matsumura, Cintia Yuri
Published in
Skeletal muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutations in the DMD gene, leading to the absence of dystrophin. DMD results in muscle weakness, loss of ambulation, and death at an early age. Metabolomics studies in mdx mice, the most used model for DMD, reveal changes in metabolite...
Vankrunkelsven, Wouter Thiessen, Steven Derde, Sarah Vervoort, Ellen Derese, Inge Pintelon, Isabel Matheussen, Hanne Jans, Alexander Goossens, Chloë Langouche, Lies
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Published in
Skeletal muscle
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that mediates adaptive responses to tissue injury and repair in various chronic pathological conditions. Animal studies have suggested that the critical illness-induced ...
Witcher, Phillip C Sun, Chengyi Millay, Douglas P
Published in
Skeletal muscle
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two muscle-specific fusogens, Myomaker and Myomerger, which function by remodeling cell membranes to fuse to each other or to existing myofibers. Myomaker and Myomerger expression is restrict...
Redmond, Anna K Davies, Tilman M Schofield, Matthew R Sheard, Philip W
Published in
Skeletal muscle
The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers across the muscle belly. Many muscles feature a non-uniform spatial pattern of fiber types, and alterations to the arrangement can reflect age or disease and correlate with changes in muscle mass and strength. Despite the significa...
Ismaeel, Ahmed Van Pelt, Douglas W Hettinger, Zachary R Fu, Xu Richards, Christopher I Butterfield, Timothy A Petrocelli, Jonathan J Vechetti, Ivan J Confides, Amy L Drummond, Micah J
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Published in
Skeletal muscle
Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects. Whether extracellular vesicles (EVs) also play a role in the SkM adaptive response and ability to communicate with other tissues is not well understood. The purpose of this study was to investigate EV biog...
Claus, Clothilde Slavin, Moriya Ansseau, Eugénie Lancelot, Céline Bah, Karimatou Lassche, Saskia Fiévet, Manon Greco, Anna Tomaiuolo, Sara Tassin, Alexandra
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Published in
Skeletal muscle
We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles. Based on gain- and loss-of-function studies we have proposed DUX4c involvement in muscle regeneration. Here, we provide further evidence for such a role in skeletal muscles from patients affec...
