Ma, Rui Kwok, Hang Fai
Published in
Seminars in cancer biology
Due to advances in detection and treatment of cancer, especially the rise in the targeted therapy, the five-year relative survival rate of all cancers has increased significantly. However, according to the analysis of the survival rate of cancer patients in 2019, the survival rate of most cancers is still less than five years. Therefore, to combat ...
Florean, Cristina Dicato, Mario Diederich, Marc
Published in
Seminars in cancer biology
The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at reverting pro-tumor inflammation and stimulating the antitumor immune components are being actively s...
Patra, Srimanta Mishra, Soumya R Behera, Bishnu P Mahapatra, Kewal K Panigrahi, Debasna P Bhol, Chandra S Praharaj, Prakash P Sethi, Gautam Patra, Samir K Bhutia, Sujit K
...
Published in
Seminars in cancer biology
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to maintain cyto-homeostasis. Autophagy sustains a dynamic interlink between cytoprotective and cytostatic function during malignant transformation in a context-dependent manner. T...
Ma, Zhaowu Xiang, Xiaoqiang Li, Shiya Xie, Peng Gong, Quan Goh, Boon-Cher Wang, Lingzhi
Published in
Seminars in cancer biology
Rapid progress in molecular cancer biology coupled with the discovery of novel oncology drugs has opened new horizons for cancer target discovery. As one of the crucial signaling pathways related to tumorigenesis, hypoxia-inducible factor-1 (HIF-1) coordinates the activity of many transcription factors and their downstream molecules that impact tum...
Gupta, Bhavika Sadaria, Daizy Warrier, Vaishnavi U Kirtonia, Anuradha Kant, Ravi Awasthi, Amit Baligar, Prakash Pal, Jayanta K Yuba, Eiji Sethi, Gautam
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Published in
Seminars in cancer biology
Plant lectins, a natural source of glycans with a therapeutic potential may lead to the discovery of new targeted therapies. Glycans extracted from plant lectins are known to act as ligands for C-type lectin receptors (CLRs) that are primarily present on immune cells. Plant-derived glycosylated lectins offer diversity in their N-linked oligosacchar...
Khatoon, Elina Banik, Kishore Harsha, Choudhary Sailo, Bethsebie Lalduhsaki Thakur, Krishan Kumar Khwairakpam, Amrita Devi Vikkurthi, Rajesh Devi, Thengujam Babita Gupta, Subash C Kunnumakkara, Ajaikumar B
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Published in
Seminars in cancer biology
Despite significant advancements made in the treatment of cancer during the past several decades, it remains one of the leading causes of death worldwide killing approximately 9.6 million people annually. The major challenge for therapeutic success is the development of chemoresistance in cancer cells against conventional chemotherapeutic agents vi...
Moloudizargari, Milad Asghari, Mohammad Hossein Nabavi, Seyed Fazel Gulei, Diana Berindan-Neagoe, Ioana Bishayee, Anupam Nabavi, Seyed Mohammad
Published in
Seminars in cancer biology
The current era of cancer research has been continuously advancing upon identifying novel aspects of tumorigenesis and the principal mechanisms behind the unleashed proliferation, invasion, drug resistance and immortality of cancer cells in hopes of exploiting these findings to achieve a more effective treatment for cancer. In pursuit of this goal,...
Fakhri, Sajad Moradi, Seyed Zachariah Farzaei, Mohammad Hosein Bishayee, Anupam
Published in
Seminars in cancer biology
Several signaling pathways and basic metabolites are responsible for the control of metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism, the abnormal activities of these pathways are of the most noticeable events in cancer. This altered metabolism expedites the survival and proliferation of cancer cells, which hav...
Braicu, Cornelia Zanoaga, Oana Zimta, Alina-Andreea Tigu, Adrian Bogdan Kilpatrick, Kaitlyn L Bishayee, Anupam Nabavi, Seyed Mohammad Berindan-Neagoe, Ioana
Published in
Seminars in cancer biology
Due to the high number of annual cancer-related deaths, and the economic burden that this malignancy affects today's society, the study of compounds isolated from natural sources should be encouraged. Most cancers are the result of a combined effect of lifestyle, environmental factors, and genetic and hereditary components. Recent literature reveal...
Andrijauskaite, Kristina Wargovich, Michael J
Published in
Seminars in cancer biology
Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the quality of life of cancer patients, b...
