Zhang, Jing Hu, Zhimin Horta, Calista A Yang, Jing
Published in
Seminars in cancer biology
Epithelial-mesenchymal transition (EMT) has been implicated in various aspects of tumor development, including tumor invasion and metastasis, cancer stemness, and therapy resistance. Diverse stroma cell types along with biochemical and biophysical factors in the tumor microenvironment impinge on the EMT program to impact tumor progression. Here we ...
Heuser, Christoph Renner, Kathrin Kreutz, Marina Gattinoni, Luca
Published in
Seminars in cancer biology
Immune checkpoint inhibitors and adoptive T cell therapies have been valuable additions to the toolbox in the fight against cancer. These treatments have profoundly increased the number of patients with a realistic perspective toward a return to a cancer-free life. Yet, in a number of patients and tumor entities, cancer immunotherapies have been in...
Leung, Elaine Lai-Han Fan, Xing-Xing Huang, Ju-Min Huang, Chen Lin, Hong Cao, Ya-Bing
Published in
Seminars in cancer biology
Small cell lung cancer (SCLC) is characterized by a high mortality rate, rapid growth, and early metastasis, which lead to a poor prognosis. Moreover, limited clinical treatment options further lower the survival rate of patients. Therefore, novel technology and agents are urgently required to enhance clinical efficacy. In this review, from a holis...
Ying, Minfeng Hu, Xun
Published in
Seminars in cancer biology
Cancer cells are characterized by sustained proliferation, which requires a huge demand of fuels to support energy production and biosynthesis. Energy is produced by the oxidation of the fuels during catabolism, and biosynthesis is achieved by the reduction of smaller units or precursors. Therefore, the oxidation-reduction (redox) reactions in canc...
Gal, Hilah Majewska, Julia Krizhanovsky, Valery
Published in
Seminars in cancer biology
Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced secretory activity, has functional roles in both physiological and pathological conditions. Although senescence has been linked for a long time with cancer and ageing, recent studies have revealed a functional role of senescence in development, regeneration and repro...
Ervin, Egle-Helene French, Rhiannon Chang, Chao-Hui Pauklin, Siim
Published in
Seminars in cancer biology
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of transcription factor expression and/or activity enables cancer cell to acquire a stem-like state characterised by capacity to self-renew, differentiate and form tumours in vivo. These stem-like cancer cells are highly metastatic and therapy resistant, thu...
Rackles, Elisabeth Lopez, Patricia Hernández Falcon-Perez, Juan M
Published in
Seminars in cancer biology
The analysis of extracellular vesicles (EVs) as a source of cancer biomarkers is an emerging field since low-invasive biomarkers are highly demanded. EVs constitute a heterogeneous population of small membrane-contained vesicles that are present in most of body fluids. They are released by all cell types, including cancer cells and their cargo cons...
Moreno-Andrés, Daniel Holl, Kristin Antonin, Wolfram
Published in
Seminars in cancer biology
The nucleus undergoes dramatic structural and functional changes during cell division. With the entry into mitosis, in human cells the nuclear envelope breaks down, chromosomes rearrange into rod-like structures which are collected and segregated by the spindle apparatus. While these processes in the first half of mitosis have been intensively stud...
Zhu, Mengxuan Li, Suyao Cao, Xin Rashid, Khalid Liu, Tianshu
Published in
Seminars in cancer biology
Signal transducer and activator of transcription (STAT) proteins compose a family of transcription factors critical for cancer stem cells (CSCs), and they are involved in maintaining stemness properties, enhancing cell proliferation, and promoting metastasis. Recent studies suggest that STAT proteins engage in reciprocal communication between CSCs ...
Sun, Runzi Gao, David Shihong Shoush, Jason Lu, Binfeng
Published in
Seminars in cancer biology
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ. These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL-1RAcP), the IL-18 receptor (IL-18Rα and IL-18Rβ), the IL-33 receptor (ST2 and IL-1RAcP), and the IL-36 receptor (IL-1Rrp2 and IL-1RAcP). The formation of receptor co...
