Levayer, Romain
Published in
Seminars in cancer biology
The regulation of cell growth, cell proliferation and cell death is at the basis of the homeostasis of tissues. While they can be regulated by intrinsic and genetic factors, their response to external signals emanating from the local environment is also essential for tissue homeostasis. Tumour initiation and progression is based on the misregulatio...
Lawlor, Katerina Pérez-Montero, Salvador Lima, Ana Rodríguez, Tristan A
Published in
Seminars in cancer biology
The maintenance of tissue homeostasis and health relies on the efficient removal of damaged or otherwise suboptimal cells. One way this is achieved is through cell competition, a fitness quality control mechanism that eliminates cells that are less fit than their neighbours. Through this process, cell competition has been shown to play diverse role...
Burns, Jessica Wilding, Christopher P L Jones, Robin H Huang, Paul
Published in
Seminars in Cancer Biology
Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made over the past few decades. Prote...
Harrison, Peter T. Vyse, Simon Huang, Paul H.
Published in
Seminars in Cancer Biology
Epidermal growth factor receptor ( EGFR ) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) comprise the vast majority of EGFR mutations and are well defined as strong predictors for good clinical response to EGFR tyrosin...
Aggarwal, Sadhna Verma, Sumit Singh Aggarwal, Sumit Gupta, Subash Chandra
Published in
Seminars in Cancer Biology
Despite tremendous resources being invested in prevention and treatment, breast cancer remains a leading cause of cancer deaths in women globally. The available treatment modalities are very costly and produces severe side effects. Drug repurposing that relate to new uses for old drugs has emerged as a novel approach for drug development. Repositio...
Yao, Shang Fan, Lavender Yuen-Nam Lam, Eric Wing-Fai
Published in
Seminars in cancer biology
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA damage repair and cell cycle control. The development of resistance to both conventional and newly emerged molecula...
Diederich, Marc Cerella, Claudia
Published in
Seminars in cancer biology
Natural compounds are the fundament of pharmacological treatments and more than 50% of all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature. Over the last 25 years, molecular mechanisms triggered by natural anticancer compounds were investigated. Emerging research showed that molecules of natural origins ...
Tan, Shawna Barker, Nick
Published in
Seminars in Cancer Biology
The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration. How these stem cells contribute to tissue repair and normal homeo...
Vicente-Dueñas, Carolina Hauer, Julia Ruiz-Roca, Lucía Ingenhag, Deborah Rodríguez-Meira, Alba Auer, Franziska Borkhardt, Arndt Sánchez-García, Isidro
Published in
Seminars in Cancer Biology
Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, rece...
Masoudi-Nejad, Ali Bidkhori, Gholamreza Hosseini Ashtiani, Saman Najafi, Ali Bozorgmehr, Joseph H. Wang, Edwin
Published in
Seminars in Cancer Biology
Cancer has become known as a complex and systematic disease on macroscopic, mesoscopic and microscopic scales. Systems biology employs state-of-the-art computational theories and high-throughput experimental data to model and simulate complex biological procedures such as cancer, which involves genetic and epigenetic, in addition to intracellular a...
