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Non-canonical programmed cell death mechanisms triggered by natural compounds

Published in Seminars in Cancer Biology

Epithelial stem cells and intestinal cancer.

Published in Seminars in cancer biology

The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration. How these stem cells contribute to tissue repair and normal homeo...

Metabolic cancer biology: structural-based analysis of cancer as a metabolic disease, new sights and opportunities for d...

Published in Seminars in cancer biology

The cancer cell metabolism or the Warburg effect discovery goes back to 1924 when, for the first time Otto Warburg observed, in contrast to the normal cells, cancer cells have different metabolism. With the initiation of high throughput technologies and computational systems biology, cancer cell metabolism renaissances and many attempts were perfor...

Cancer systems biology and modeling: microscopic scale and multiscale approaches.

Published in Seminars in cancer biology

Cancer has become known as a complex and systematic disease on macroscopic, mesoscopic and microscopic scales. Systems biology employs state-of-the-art computational theories and high-throughput experimental data to model and simulate complex biological procedures such as cancer, which involves genetic and epigenetic, in addition to intracellular a...

Asymmetric cell division of stem and progenitor cells during homeostasis and cancer.

Published in Cellular and molecular life sciences : CMLS

Stem and progenitor cells are characterized by their ability to self-renew and produce differentiated progeny. A fine balance between these processes is achieved through controlled asymmetric divisions and is necessary to generate cellular diversity during development and to maintain adult tissue homeostasis. Disruption of this balance may result i...

Nucleoporins and nucleocytoplasmic transport in hematologic malignancies.

Published in Seminars in cancer biology

Hematologic malignancies are often associated with chromosomal rearrangements that lead to the expression of chimeric fusion proteins. Rearrangements of the genes encoding two nucleoporins, NUP98 and NUP214, have been implicated in the pathogenesis of several types of hematologic malignancies, particularly acute myeloid leukemia. NUP98 rearrangemen...

Nuclear transport of galectin-3 and its therapeutic implications.

Published in Seminars in cancer biology

Galectin-3, a member of β-galactoside-binding gene family is a multi-functional protein, which regulates pleiotropic biological functions such as cell growth, cell adhesion, cell-cell interactions, apoptosis, angiogenesis and mRNA processing. Its unique structure enables it to interact with a plethora of ligands in a carbohydrate dependent or indep...

Cancer-associated fibroblasts: recent developments and emerging challenges.

Published in Seminars in cancer biology

Prognostic relevance of cancer-associated fibroblasts in human cancer.

Published in Seminars in cancer biology

Prognostication is an integral part of cancer diagnostic and helps oncologists to guide treatment decisions and therapy intensity. Accumulating evidence suggest that the stroma compartment also contains independent prognostic information, best exemplified by the impact of immune cells and cells of the vasculature on cancer progression. Similarly, s...