Filipiak, Michał Woyciechowski, Michal Czarnoleski, Marcin
Published in
Scientific Reports
Life histories of species may be shaped by nutritional limitations posed on populations. Yet, populations contain individuals that differ according to sex and life stage, each of which having different nutritional demands and experiencing specific limitations. We studied patterns of resource assimilation, allocation and excretion during the growth ...
Park, Chang-hyun Bang, Mirim Ahn, Kook Jin Kim, Woo Jung Shin, Na-Young
Published in
Scientific Reports
Disturbed sleep is the most common effect of shift work. A large corpus of research indicates an association between sleep disturbance and depressive symptom in shift workers. In this study, we proposed the mediating role of grey matter (GM) structure in the relationship between sleep disturbance and depressive symptom. We collected structural MRI ...
Wessel, Maximilian J. Draaisma, Laurijn R. de Boer, Anne F. W. Park, Chang-hyun Maceira-Elvira, Pablo Durand-Ruel, Manon Koch, Philipp J. Morishita, Takuya Hummel, Friedhelm C.
Published in
Scientific Reports
The development of novel strategies to augment motor training success is of great interest for healthy persons and neurological patients. A promising approach is the combination of training with transcranial electric stimulation. However, limited reproducibility and varying effect sizes make further protocol optimization necessary. We tested the ef...
Priya, Sarv Liu, Yanan Ward, Caitlin Le, Nam H. Soni, Neetu Pillenahalli Maheshwarappa, Ravishankar Monga, Varun Zhang, Honghai Sonka, Milan Bathla, Girish
...
Published in
Scientific Reports
Few studies have addressed radiomics based differentiation of Glioblastoma (GBM) and intracranial metastatic disease (IMD). However, the effect of different tumor masks, comparison of single versus multiparametric MRI (mp-MRI) or select combination of sequences remains undefined. We cross-compared multiple radiomics based machine learning (ML) mode...
Dutta, Ravi Kumar Larsson, Malin Arnesen, Thomas Heie, Anette Walz, Martin Alesina, Piero Gimm, Oliver Söderkvist, Peter
Published in
Scientific Reports
Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism (PA) and are characterized by constitutively producing aldosterone, which leads to hypertension. Several mutations have been identified in ion channels or ion channel-associated genes that result in APAs. To date, no studies have used a genome-wide association study (G...
Alhourani, Abdelnour H. Tidwell, Tia R. Bokil, Ansooya A. Røsland, Gro V. Tronstad, Karl Johan Søreide, Kjetil Hagland, Hanne R.
Published in
Scientific Reports
Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized and poorly understood area of cancer therapy. Metformin, a metabolic drug commonly used to treat type 2 diabetes, has been associated with lower cancer incidence, although studies are inconc...
Kirse, Ameli Bourlat, Sarah J. Langen, Kathrin Fonseca, Vera G.
Published in
Scientific Reports
Forest habitats host enormous diversity, but little is known about the seasonal turnover of arthropod species between the above- and below ground forest layers. In this study, we used metabarcoding approaches to uncover arthropod diversity in different forest types and seasons. Our study shows that metabarcoding soil eDNA and Malaise trap bulk samp...
Fernandes, Mara Yone D. Dobrachinski, Fernando Silva, Henrique B. Lopes, João Pedro Gonçalves, Francisco Q. Soares, Felix A. A. Porciúncula, Lisiane O. Andrade, Geanne M. Cunha, Rodrigo A. Tomé, Angelo R.
...
Published in
Scientific Reports
The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorog...
Yousefi, Meysam Rajaie, Sara Keyvani, Vahideh Bolandi, Somayeh Hasanzadeh, Malihe Pasdar, Alireza
Published in
Scientific Reports
Circulating tumor cells (CTCs) have recently been considered as new prognostic and diagnostic markers for various human cancers; however, their significance in epithelial ovarian cancer (EOC) remains to be elucidated. In this study, using quantitative real-time PCR, we evaluated the expression of EPCAM, MUC1, CEA, HE4 and CA125 mRNAs, as putative m...
Leach, Adam Miller, Ami Bentley, Emma Mattiuzzo, Giada Thomas, Jemima McAndrew, Craig Van Montfort, Rob Rabbitts, Terence
Published in
Scientific Reports
Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 disease. Therapeutic antibodies are being developed that interact with the viral spike proteins to limit viral infection of epithelium. We have applied a method to dramatically improve the performance of anti-SARS-CoV-2 antibodies by enhancing avidity thro...
