Gaillard, Marie-Cécile Broucqsault, Natacha Morere, Julia Laberthonnière, Camille Dion, Camille Badja, Cherif Roche, Stéphane Nguyen, Karine Magdinier, Frédérique Robin, Jérôme D.
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Published in
Scientific Reports
Facio-Scapulo Humeral dystrophy (FSHD) is the third most common myopathy, affecting 1 amongst 10,000 individuals (FSHD1, OMIM #158900). This autosomal dominant pathology is associated in 95% of cases with genetic and epigenetic alterations in the subtelomeric region at the extremity of the long arm of chromosome 4 (q arm). A large proportion of the...
Anastasiou, A. D. Nerantzaki, M. Gounari, E. Duggal, M. S. Giannoudis, P. V. Jha, A. Bikiaris, D.
Published in
Scientific Reports
Scaffolds and implants in orthopaedics and regenerative dentistry usually fail because of bacterial infections. A promising solution would be the development of biomaterials with both significant regenerative potential and enhanced antibacterial activity. Working towards this direction, fluorapatite was synthesised and doped with Sr2+ and Ce3+ ions...
Gobeil, Sophie M. C. Ebert, Maximillian C. C. J. C. Park, Jaeok Gagné, Donald Doucet, Nicolas Berghuis, Albert M. Pleiss, Jürgen Pelletier, Joelle N.
Published in
Scientific Reports
Understanding the principles of protein dynamics will help guide engineering of protein function: altering protein motions may be a barrier to success or may be an enabling tool for protein engineering. The impact of dynamics on protein function is typically reported over a fraction of the full scope of motional timescales. If motional patterns var...
Anani, Hussein Abou Abdallah, Rita Chelkha, Nisrine Fontanini, Anthony Ricaboni, Davide Mailhe, Morgane Raoult, Didier Fournier, Pierre-Edouard
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Scientific Reports
We used phenotypic, genomic and phylogenetic information following the taxono-genomics approach to demonstrate that strain Marseille–P3254, isolated from an ileal sample of a 76-year old woman who underwent upper and lower digestive tract endoscopy for esophagitis and colonic polyp, is representative of a novel bacterial genus within the family Ery...
Mulatier, Margaux Camara, Soromane Koffi, Alphonsine Carrasco, David Porciani, Angélique Chandre, Fabrice Moiroux, Nicolas Lefevre, Thierry Dabiré, Roch Assi, Serge
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Published in
Scientific Reports
Within mosquito vector populations, infectious mosquitoes are the ones completing the transmission of pathogens to susceptible hosts and they are, consequently, of great epidemiological interest. Mosquito infection by malaria parasites has been shown to affect several traits of mosquito physiology and behavior, and could interplay with the efficacy...
Olvera, Mariana Rosas Garai, Preeti Mongin, Grégoire Vivès, Eric Gannoun-Zaki, Laila Blanc-Potard, Anne-Béatrice
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Scientific Reports
Due to the antibiotic resistance crisis, novel therapeutic strategies need to be developed against bacterial pathogens. Hydrophobic bacterial peptides (small proteins under 50 amino acids) have emerged as regulatory molecules that can interact with bacterial membrane proteins to modulate their activity and/or stability. Among them, the Salmonella M...
Mandon, Marion Huet, Sylvie Dubreil, Estelle Fessard, Valérie Le Hégarat, Ludovic
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Scientific Reports
Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell interactions has occurred to a...
Cusset, Fanny Fort, Jérôme Mallory, Mark Braune, Birgit Massicotte, Philippe Massé, Guillaume
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Scientific Reports
In the Arctic, sea-ice plays a central role in the functioning of marine food webs and its rapid shrinking has large effects on the biota. It is thus crucial to assess the importance of sea-ice and ice-derived resources to Arctic marine species. Here, we used a multi-biomarker approach combining Highly Branched Isoprenoids (HBIs) with δ13C and δ15N...
Franz, Dominik Kaassamani, Shatha Gauthier, David Nicolas, Rana Kholodtsova, Maria Douillard, Ludovic Gomes, Jean-Thomas Lavoute, Laure Gaponov, Dmitry Ducros, Nicolas
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Published in
Scientific Reports
The enhancement and control of non-linear phenomena at a nanometer scale has a wide range of applications in science and in industry. Among these phenomena, high-harmonic generation in solids is a recent focus of research to realize next generation petahertz optoelectronic devices or compact all solid state EUV sources. Here, we report on the reali...
Bouillet, Sophie Ba, Moly Houot, Laetitia Iobbi-Nivol, Chantal Bordi, Christophe
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Scientific Reports
Biofilm formation is a complex process resulting from the action of imbricated pathways in response to environmental cues. In this study, we showed that biofilm biogenesis in the opportunistic pathogen Pseudomonas aeruginosa depends on the availability of RpoS, the sigma factor regulating the general stress response in bacteria. Moreover, it was de...
