Meng, Lanxia Liu, Congcong Li, Yiming Chen, Guiqin Xiong, Min Yu, Ting Pan, Lina Zhang, Xingyu Zhou, Lingyan Guo, Tao
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Science advances
Parkinson's disease (PD) is characterized by the pathologic aggregation and prion-like propagation of α-synuclein (α-syn). Emerging evidence shows that fungal infections increase the incidence of PD. However, the molecular mechanisms by which fungi promote the onset of PD are poorly understood. Here, we show that nasal infection with Saccharomyces ...
Pohl, Franziska Germann, Allison L Mao, Jack Hou, Sydney Bakare, Bayode Kong Thoo Lin, Paul Yates, Kyari Nonet, Michael L Akk, Gustav Kornfeld, Kerry
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Science advances
The γ-aminobutyric acid-mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction, and life-span extension. Many of these phenotypes are also regulated by reactive oxygen species (ROS), but the redox mechanisms linking the GABAergic system to these phenotypes are not ...
Zhu, Yifan Ge, Xiaowei Ni, Hongli Yin, Jiaze Lin, Haonan Wang, Le Tan, Yuying Prabhu Dessai, Chinmayee V Li, Yueming Teng, Xinyan
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Science advances
Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing molecular structures, dynamics, and couplings in complex systems. However, the sensitivity of SRS is fundamentally limited to the millimolar level due to shot noise and the small modulation depth. To overcome this barrier, we revisit SRS from the perspective of e...
Hildenbrand, Karen Bohnacker, Sina Menon, Priyanka Rajeev Kerle, Anna Prodjinotho, Ulrich F Hartung, Franziska Strasser, Patrick C Catici, Dragana A M Rührnößl, Florian Haslbeck, Martin
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Science advances
Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position in inflammatory and infectious diseases. Each family member consists of an α and a β subunit that together form a composite cytokine. Within the IL-12 family, IL-35 remains particularly ill-characterized on a mo...
Davydova, Margarita Prembabu, Saranesh Fu, Liang
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Science advances
We propose a universal mechanism for the Josephson diode effect in short Josephson junctions. The proposed mechanism is due to finite Cooper pair momentum and is a manifestation of simultaneous breaking of inversion and time-reversal symmetries. The diode efficiency is up to 40%, which corresponds to an asymmetry between the critical currents in op...
Li, Lingxiao Wei, Jinfei Zhang, Junping Li, Bucheng Yang, Yanfei Zhang, Jiaojiao
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Science advances
Superhydrophobic (SH) surfaces have progressed rapidly in fundamental research over the past 20 years, but their practical applications lag far behind. In this perspective, we first present the findings of a survey on the current state of SH surfaces including fundamental research, patenting, and commercialization. On the basis of the survey and ou...
Li, Chenghai Schramma, Nico Wang, Zijun Qari, Nada F Jalaal, Maziyar Latz, Michael I Cai, Shengqiang
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Science advances
Mechanosensing, the transduction of extracellular mechanical stimuli into intracellular biochemical signals, is a fundamental property of living cells. However, endowing synthetic materials with mechanosensing capabilities comparable to biological levels is challenging. Here, we developed ultrasensitive and robust mechanoluminescent living composit...
Ben-Artzi, Ido Kessler, Yoav Nicenboim, Bruno Shahar, Nitzan
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Science advances
Current studies suggest that individuals estimate the value of their choices based on observed feedback. Here, we ask whether individuals also update the value of their unchosen actions, even when the associated feedback remains unknown. One hundred seventy-eight individuals completed a multi-armed bandit task, making choices to gain rewards. We fo...
Fukano, Yuya Yamori, Wataru Misu, Hayata Sato, Mitsuhiko P Shirasawa, Kenta Tachiki, Yuuya Uchida, Kei
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Science advances
Prevalence of impervious surface and resulting higher temperatures in urban areas, known as urban heat islands, comprises prominent characteristics in global cities. However, it is not known whether and how urban plants adapt to such heat stress. This study focused on Oxalis corniculata, which has intraspecific polymorphism in leaf color (green and...
Shiota, Tomoyuki Li, Zhucui Chen, Guan-Yuan McKnight, Kevin L Shirasaki, Takayoshi Yonish, Bryan Kim, Heyjeong Fritch, Ethan J Sheahan, Timothy P Muramatsu, Masamichi
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Science advances
Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA sequencing and genetic depletion studies, we show that hepatitis A virus, an hepatotropic picor...
