Kliche, Johanna Kuss, Hanna Ali, Muhammad Ivarsson, Ylva
Published in
Science Signaling
The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2 and integrins contain several predicted short linear ...
Mészáros, Bálint Sámano-Sánchez, Hugo Alvarado-Valverde, Jesús Čalyševa, Jelena Martínez-Pérez, Elizabeth Alves, Renato Kumar, Manjeet Rippmann, Friedrich Chemes, Lucía B. Gibson, Toby J.
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The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented wit...
Milewska, Aleksandra Falkowski, Katherine Kulczycka, Magdalena Bielecka, Ewa Naskalska, Antonina Mak, Pawel Lesner, Adam Ochman, Marek Urlik, Maciej Diamandis, Elftherios
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Published in
Science Signaling
Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the con...
Torrent, Marc Chalancon, Guilhem de Groot, Natalia S. Wuster, Arthur Babu, M. Madan
Published in
Science Signaling
Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation efficiency. To determine whether cells alter tRNA abundance to selectively regulate protein expression, we quantified changes in the abundance of individual tRNAs at different time points in response...
Gao, R Zhao, S Jiang, X Sun, S Zhao, S Gao, J Borleis, J Willard, S Tang, M Cai, H
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Published in
Science Signaling
Mieulet, Virginie Yan, Lijun Choisy, Caroline Sully, Katherine Procter, Julia Kouroumalis, Andreas Krywawych, Steve Mario Pende Ley, Steven C Moinard, Christophe
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Published in
Science Signaling
The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1 (ERK1) and ERK2, are activated after the stimulation of macrophages with bacterial lipopolysaccharide (LPS) and are necessary for the optimal production of proinflammatory cytokines ...
B. Bonneau Adrien NOUGARÈDE J. Prudent N. Popgeorgiev N. Peyrieras R. Rimokh G. Gillet
Published in
Science Signaling
Potts, Mb Kim, Hs Fisher, Kw Hu, Y Carrasco, Yp Bulut, Gb Ou, Yh Herrera-Herrera, Ml Cubillos, F Mendiratta, S
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Published in
Science Signaling
A challenge for biomedical research is the development of pharmaceuticals that appropriately target disease mechanisms. Natural products can be a rich source of bioactive chemicals for medicinal applications but can act through unknown mechanisms and can be difficult to produce or obtain. To address these challenges, we developed a new marine-deriv...
Jian, Z Han, H Zhang, T Puglisi, J Izu, Lt Shaw, Ja Ekama Onofiok Erickson, Jr Chen, Yj Horvath, B
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Published in
Science Signaling
Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical load to alter Ca(2+) dynamics. In mouse ventricular ...
