A large scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum
...Published in Science Signaling
The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.
Published in Science Signaling
Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development through VEGF receptors (VEGFRs). The VEGFR immunoglobulin homology domain 2 (D2) is critical for ligand binding, and D3 provides additional interaction sites. VEGF-B and placenta growth factor (PlGF) bind to VEGFR-1 with high affinity, but only PlGF is angio...
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
...Published in Science Signaling
The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a phenomenon called "oncogene addiction." We demonstrate that PUMA and BIM are the key apoptotic effectors of tyrosine kinase inhibitors in breast cancers with amplification of the gene encoding human...
Using functional signature ontology (FUSION) to identify mechanisms of action for natural products.
...Published in Science Signaling
A challenge for biomedical research is the development of pharmaceuticals that appropriately target disease mechanisms. Natural products can be a rich source of bioactive chemicals for medicinal applications but can act through unknown mechanisms and can be difficult to produce or obtain. To address these challenges, we developed a new marine-deriv...
The Bcl-2 Homolog Nrz Inhibits Binding of IP3 to Its Receptor to Control Calcium Signaling During Zebrafish Epiboly.
Published in Science Signaling
Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.
...Published in Science Signaling
Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical load to alter Ca(2+) dynamics. In mouse ventricular ...
