Cai, Yuping Kim, Daniel J Takahashi, Takehiro Broadhurst, David I Yan, Hong Ma, Shuangge Rattray, Nicholas J W Casanovas-Massana, Arnau Israelow, Benjamin Klein, Jon
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Published in
Science signaling
Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA-to-kynurenine (K) ratio (...
Ferrucci, Veronica Kong, Dae-Young Asadzadeh, Fatemeh Marrone, Laura Boccia, Angelo Siciliano, Roberto Criscuolo, Giuseppina Anastasio, Camilla Quarantelli, Fabrizio Comegna, Marika
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Science Signaling
Inorganic polyphosphates (polyPs) are linear polymers composed of repeated phosphate (PO43−) units linked together by multiple high-energy phosphoanhydride bonds. In addition to being a source of energy, polyPs have cytoprotective and antiviral activities. Here, we investigated the antiviral activities of long-chain polyPs against severe acute resp...
Minasov, George Rosas-Lemus, Monica Shuvalova, Ludmilla Inniss, Nicole L. Brunzelle, Joseph S. Daczkowski, Courtney M. Hoover, Paul Mesecar, Andrew D. Satchell, Karla J. F.
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Science Signaling
Capping of viral messenger RNAs is essential for efficient translation, for virus replication, and for preventing detection by the host cell innate response system. The SARS-CoV-2 genome encodes the 2′- O -methyltransferase nsp16, which, when bound to the coactivator nsp10, uses S -adenosylmethionine (SAM) as a donor to transfer a methyl group to t...
Kliche, Johanna Kuss, Hanna Ali, Muhammad Ivarsson, Ylva
Published in
Science Signaling
The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2 and integrins contain several predicted short linear ...
Mészáros, Bálint Sámano-Sánchez, Hugo Alvarado-Valverde, Jesús Čalyševa, Jelena Martínez-Pérez, Elizabeth Alves, Renato Kumar, Manjeet Rippmann, Friedrich Chemes, Lucía B. Gibson, Toby J.
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The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented wit...
Milewska, Aleksandra Falkowski, Katherine Kulczycka, Magdalena Bielecka, Ewa Naskalska, Antonina Mak, Pawel Lesner, Adam Ochman, Marek Urlik, Maciej Diamandis, Elftherios
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Published in
Science signaling
Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the con...
Torrent, Marc Chalancon, Guilhem de Groot, Natalia S. Wuster, Arthur Babu, M. Madan
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Science Signaling
Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation efficiency. To determine whether cells alter tRNA abundance to selectively regulate protein expression, we quantified changes in the abundance of individual tRNAs at different time points in response...
Gao, R Zhao, S Jiang, X Sun, S Zhao, S Gao, J Borleis, J Willard, S Tang, M Cai, H
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Science Signaling
Mieulet, Virginie Yan, Lijun Choisy, Caroline Sully, Katherine Procter, Julia Kouroumalis, Andreas Krywawych, Steve Mario Pende Ley, Steven C Moinard, Christophe
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Science Signaling
The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1 (ERK1) and ERK2, are activated after the stimulation of macrophages with bacterial lipopolysaccharide (LPS) and are necessary for the optimal production of proinflammatory cytokines ...
B. Bonneau Adrien NOUGARÈDE J. Prudent N. Popgeorgiev N. Peyrieras R. Rimokh G. Gillet
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Science Signaling