Evolution of genes and genomes: an emerging paradigm in life science
Published in Science China Life Sciences
Developing an efficient multiplex PCR method to detect mcr-like genes
Published in Science China Life Sciences
Design of high performance nanozymes: a single-atom strategy
Published in Science China Life Sciences
Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance ...
Published in Science China Life Sciences
Pattern recognition receptors (PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and C-type lectin receptors (CLRs) were ...
Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturba...
...Published in Science China Life Sciences
Antipsychotic-induced metabolic disturbance (AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor (MC4R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a...
The 2018 Nobel Prize in Chemistry: Engineering proteins (enzymes/peptide/antibodies) towards desired properties via the ...
Published in Science China Life Sciences
Regulatory perspective of antibiotic biosynthesis in Streptomyces
Published in Science China Life Sciences
Phylogenetic relationships of Cypriniformes and plasticity of pharyngeal teeth in the adaptive radiation of cyprinids
Published in Science China Life Sciences
The Cypriniformes comprise approximately 4,200 species accounting for 25% of the diversity of all freshwater fish, which is widely distributed across the world’s continents except Antarctica, South America, and Australia. The highest species diversity is found in Southeastern Asia. Despite its remarkable species diversity and broad-scale geographic...
Synthetic chromosome evolves the yeast genome
Published in Science China Life Sciences
Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testi...
Published in Science China Life Sciences
The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. More than 40% (9,206) of these TFBS-HS are in the vic...
