Wang, Xiaoyu Ma, Cuicui Rodríguez Labrada, Roberto Qin, Zhou Xu, Ting He, Zhiyao Wei, Yuquan
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Science China Life Sciences
Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells. With the extensive and in-depth studies on this gene therapy vehicle over the past two decades, LVs have been widely used in both research and clinical trials. For ins...
Yu, Bo Li, Chenze Chen, Peng Zhou, Ning Wang, Luyun Li, Jia Jiang, Hualiang Wang, Dao-Wen
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Science China Life Sciences
Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality. The most urgent need is to find effective treatments. We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients. In this retrospective study, we included 550 critically ill COVID-19 pati...
Zhang, Hong Ji, Xiong Li, Pilong Liu, Cong Lou, Jizhong Wang, Zheng Wen, Wenyu Xiao, Yue Zhang, Mingjie Zhu, Xueliang
...
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Science China Life Sciences
Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking a...
Hu, Yue-Mei Guo, Meng Li, Chang-Gui Chu, Kai He, Wen-Gang Zhang, Jing Gu, Jian-Xiang Li, Juan Zhao, Hui Wu, Xiang-Hong
...
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Science China Life Sciences
A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women. A randomized, immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China. Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6 (n=301) or 3 doses at months 0, 1 and 6 (...
Chen, Weiye Zhao, Dongming He, Xijun Liu, Renqiang Wang, Zilong Zhang, Xianfeng Li, Fang Shan, Dan Chen, Hefeng Zhang, Jiwen
...
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Science China Life Sciences
African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in spe...
Liu, Yingxia Yang, Yang Zhang, Cong Huang, Fengming Wang, Fuxiang Yuan, Jing Wang, Zhaoqin Li, Jinxiu Li, Jianming Feng, Cheng
...
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Science China Life Sciences
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients ...
Li, Xiang Song, Yuhe Wong, Gary Cui, Jie
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Science China Life Sciences
Wang, Huijuan Zhou, Jianfang Wang, Dayan Huang, Baoying Tan, Wenjie
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Science China Life Sciences
The H7 subtype avian influenza threatens public health with respect to poultry and humans. Thus, a specific and sensitive diagnostic test is essential for the management of H7 subtype influenza infections. In this study, five mouse monoclonal antibodies (mAbs) against hemagglutinin (HA) of influenza A/Anhui/1/2013 (H7N9) were produced and character...
Xu, Xintian Chen, Ping Wang, Jingfang Feng, Jiannan Zhou, Hui Li, Xuan Zhong, Wu Hao, Pei
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Science China Life Sciences
Xia, Yuying Huang, Gai Zhu, Yuxian
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Science China Life Sciences