Zhu, Fengfeng Zhang, Lichuan Wang, Xiao dos Santos, Flaviano José Song, Junda Mueller, Thomas Schmalzl, Karin Schmidt, Wolfgang F. Ivanov, Alexandre Park, Jitae T.
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Published in
Science Advances
The bosonic analogs of topological insulators have been proposed in numerous theoretical works, but their experimental realization is still very rare, especially for spin systems. Recently, two-dimensional (2D) honeycomb van der Waals ferromagnets have emerged as a new platform for topological spin excitations. Here, via a comprehensive inelastic n...
Zhao, Yu Xie, Yu-Qing Van Herck, Simon Nassiri, Sina Gao, Min Guo, Yugang Tang, Li
Published in
Science Advances
Immune stimulatory antibodies and cytokines elicit potent antitumor immunity. However, the dose-limiting systemic toxicity greatly hinders their clinical applications. Here, we demonstrate a chemical approach, termed “switchable” immune modulator (Sw-IM), to limit the systemic exposure and therefore ameliorate their toxicities. Sw-IM is a biomacrom...
Garçon, Marion
Published in
Science Advances
Continents form the most accessible parts of Earth, but their complex compositions make their origin difficult to investigate. A novel approach based on a comprehensive compilation of samarium-neodymium isotopic compositions of detrital sedimentary rocks is here used to unravel continental growth through time. This record reveals that continents we...
Zheng, Bo Ciais, Philippe Chevallier, Frederic Chuvieco, Emilio Chen, Yang Yang, Hui
Published in
Science Advances
Satellites have detected a global decline in burned area of grassland, coincident with a small increase in burned forest area. These contrasting trends have been reported in earlier literature; however, less is known of their impacts on global fire emission trends due to the scarcity of direct observations. We use an atmospheric inversion system to...
Smith, Cheryl L. Lan, Yemin Jain, Rajan Epstein, Jonathan A. Poleshko, Andrey
Published in
Science Advances
The nuclear architecture of rod photoreceptor cells in nocturnal mammals is unlike that of other animal cells. Murine rod cells have an “inverted” chromatin organization with euchromatin at the nuclear periphery and heterochromatin packed in the center of the nucleus. In conventional nuclear architecture, euchromatin is mostly in the interior, and ...
Saitou, Marie Resendez, Skyler Pradhan, Apoorva J. Wu, Fuguo Lie, Natasha C. Hall, Nancy J. Zhu, Qihui Reinholdt, Laura Satta, Yoko Speidel, Leo
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Published in
Science Advances
The common deletion of the third exon of the growth hormone receptor gene ( GHRd3 ) in humans is associated with birth weight, growth after birth, and time of puberty. However, its evolutionary history and the molecular mechanisms through which it affects phenotypes remain unresolved. We present evidence that this deletion was nearly fixed in the a...
Linthwaite, Victoria L. Pawloski, Wes Pegg, Hamish B. Townsend, Philip D. Thomas, Michael J. So, Victor K. H. Brown, Adrian P. Hodgson, David R. W. Lorimer, George H. Fushman, David
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Published in
Science Advances
The identification of CO2-binding proteins is crucial to understanding CO2-regulated molecular processes. CO2 can form a reversible posttranslational modification through carbamylation of neutral N-terminal α-amino or lysine ε-amino groups. We have previously developed triethyloxonium (TEO) ion as a chemical proteomics tool for covalent trapping of...
Zhou, Changyin Zhang, Xue Miao, Yilong Zhang, Yu Li, Yu Xiong, Bo
Published in
Science Advances
During the S phase of mitosis, Sororin is recruited by acetylated Smc3 and stabilizes sister chromatid cohesion by counteracting the Wapl-Pds5 interaction. Thereafter, Sororin is phosphorylated during prophase and translocated to the cytoplasm, where its function remains poorly understood. Here, we report that Sororin acts as a regulator of meiotic...
Bell, Andrew F. Hernandez, Stephen McCloskey, John Ruiz, Mario LaFemina, Peter C. Bean, Christopher J. Möllhoff, Martin
Published in
Science Advances
The propensity for dynamic earthquake triggering is thought to depend on the local stress state and amplitude of the stress perturbation. However, the nature of this dependency has not been confirmed within a single crustal volume. Here, we show that at Sierra Negra volcano, Galápagos Islands, the intensity of dynamically triggered earthquakes incr...
Rossetti, Giulia Ermer, Judith A. Stentenbach, Maike Siira, Stefan J. Richman, Tara R. Milenkovic, Dusanka Perks, Kara L. Hughes, Laetitia A. Jamieson, Emma Xiafukaiti, Gulibaikelamu
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Published in
Science Advances
Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the MRPP3 gene, which encodes a mitochondrial RNA processing enzyme within the RNase P complex, with predicted impact on metabolism. We used CRISPR-Cas9 genome editing to introduce this variant i...
