Published in Science (New York, N.Y.)
Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pre-granulosa cells that govern testis and ovary development, respectively. While the Y-linked testis-determining gene Sry has been identified, the ovarian-determining factor remains unknown. Here we identify -KTS, a major alternative...
Published in Science (New York, N.Y.)
Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the development of five organs in five mammals (human, mouse,...
Published in Science (New York, N.Y.)
A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)-T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors. By contrast, certain species of bacteria selectively colonize immune-privileged tumor cores and can be engineered as antigen...
Published in Science (New York, N.Y.)
Edits to one gene can't completely stop infections, however.
Published in Science (New York, N.Y.)
Some whale populations are exhibiting unexpected cycles of boom and bust.
Published in Science (New York, N.Y.)
ARPA-H aims to be unlike NIH, director says.
Published in Science (New York, N.Y.)
Proteins and lipids decorated with glycans are found throughout biological entities, playing roles in biological functions and dysfunctions. Current analytical strategies for these glycan-decorated biomolecules, termed glycoconjugates, rely on ensemble averaged methods that do not provide a full view of positions and structures of glycans attached ...
Published in Science (New York, N.Y.)
Disruption of cellular activities by pathogen virulence factors can trigger innate immune responses. Interferon-γ (IFN-γ)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular pathogens and by inducing programmed cell death. Working in human macrophages, we discover...
Published in Science (New York, N.Y.)
During pregnancy physiological adaptations prepare the female body for the challenges of motherhood. Becoming a mother also requires behavioral adaptations. Such adaptations can already occur during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of es...
Published in Science (New York, N.Y.)
