Li, Yunjie Yuan, Guo Li, Linlin Kang, Jian Yan, Fengkai Du, Pengju Dierk Raabe Wang, Guodong
Published in
Science
Mechanically strong and ductile load–carrying materials are needed in all sectors, from transportation to lightweight design to safe infrastructure. Yet, a grand challenge is to unify both features in one material. We show that a plain medium-manganese steel can be processed to have a tensile strength >2.2 gigapascals at a uniform elongation >20%. ...
Lamb, Clayton T. Festa-Bianchet, Marco Boyce, Mark S. Willow Creek Capital Partners, L.P.
Published in
Science
Stephane Boyer
Published in
Science
O. M., Umurhan A. J., Verbiscer M. H., Versteeg M., Vincent R., Webbert S., Weidner G. E., Weigle O. L., White K., Whittenburg B. G., Williams
...
Published in
Science
In July 2015, the New Horizons spacecraft flew through the Pluto system at high speed, humanity's first close look at this enigmatic system on the outskirts of our solar system. In a series of papers, the New Horizons team present their analysis of the encounter data downloaded so far: Moore et al. present the complex surface features and geology o...
Stephane Boyer
Published in
Science
In October, we asked young scientists how political priorities affect their ability to do and communicate science. We received a range of answers, some frustrated by political interference, others optimistic about the ability of political attention to effect change. Although many submissions focused on pleas for more science funding, we have focuse...
Vétizou, Marie Pitt, Jonathan M Daillère, Romain Lepage, Patricia Waldschmitt, Nadine Flament, Caroline Rusakiewicz, Sylvie Routy, Bertrand Roberti, Maria P Duong, Connie P M
...
Published in
Science (New York, N.Y.)
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of CTLA-4 blockade. Tumors in antibiotic-treated or ge...
Boualem, Adnane Troadec, Christelle Camps, Céline Lemhemdi, Afef Morin, Halima Sari, Marie-Agnes Fraenkel-Zagouri, Rina Kovalski, Irina Dogimont, Catherine Perl-Treves, Rafael
...
Published in
Science (New York, N.Y.)
Understanding the evolution of sex determination in plants requires identifying the mechanisms underlying the transition from monoecious plants, where male and female flowers coexist, to unisexual individuals found in dioecious species. We show that in melon and cucumber, the androecy gene controls female flower development and encodes a limiting e...
Gentili, Matteo Kowal, Joanna Tkach, Mercedes Satoh, Takeshi Lahaye, Xavier Conrad, Cécile Boyron, Marilyn Lombard, Bérangère Durand, Sylvère Kroemer, Guido
...
Published in
Science (New York, N.Y.)
Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a cytosolic sensor for many DNA viruses and HIV-1. In response to cytosolic viral DNA, cGAS synthesizes the second messenger 2'3'-cyclic GMP-AMP (cG...
Ohnmacht, Caspar Park, Joo-Hong Cording, Sascha Wing, James B Atarashi, Koji Obata, Yuuki Gaboriau-Routhiau, Valérie Marques, Rute Dulauroy, Sophie Fedoseeva, Maria
...
Published in
Science (New York, N.Y.)
Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that...
Okada, Satoshi Markle, Janet G Deenick, Elissa K Mele, Federico Averbuch, Dina Lagos, Macarena Alzahrani, Mohammed Al-Muhsen, Saleh Halwani, Rabih Ma, Cindy S
...
Published in
Science
Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ (IFN-γ) immunity underlie mycobacterial disease. We report the discovery of bi-allelic RORC loss-of-function mutations in seven individuals from three kindreds of differen...