Published in Russian Journal of Genetics
AbstractWe analyzed samples of bees from three districts of the Republic of Bashkortostan, including samples from protected natural areas, selected with an interval of 6–8 years to assess changes in their genetic structure. The polymorphism of the intergenic region COI-COII of mitochondrial DNA and nine SSR loci of nuclear DNA was analyzed. In the ...
Published in Russian Journal of Genetics
AbstractDespite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still far from satisfactory indicators. The complex mechanisms of the LC biology are already recognized, but there is a significant gap in the knowledge about the interaction of key biomarkers in the etiolog...
Published in Russian Journal of Genetics
AbstractIn the present study, two chloroplast DNA markers (trnH-psbA, TabCD) were used to analyze genetic differentiation of six populations of Rhododendron adamsii from Sakhalin, Yakutia, Buryatia, Western Sayan, and Magadan oblast and two populations of Rhododendron parvifolium from Buryatia and Khabarovsk krai. A total of six haplotypes were fou...
Published in Russian Journal of Genetics
AbstractSearching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not allow us to come to a final conclusion about the influence of certain genes on the risk of the disease and the severity of its course. Most studies of candidate genes were carried out ...
Published in Russian Journal of Genetics
AbstractRapid development of molecular genetic technologies made it possible to analyze in detail the phenomena that can be attributed to epigenetics, i.e., phenotypic switches in bacterial cell cultures. Phenotypic changes against the background of an unchanged genome can be a temporary reaction to external factors and disappear with the change of...
Published in Russian Journal of Genetics
AbstractInfantile spasm (IS) is a common catastrophic epilepsy syndromes occurred in infancy and associated with glucocorticoid release, but its etiology is still unknown. Melatonin (MLT) is a natural hormone secreted by pineal gland associated with circadian rhythm and epilepsy. This study intended to figure out the molecular mechanism of IS thera...
Published in Russian Journal of Genetics
AbstractWe propose an ecogenetic model of “prey–predator” community with predator fitness determined genetically by a single autosomal diallelic pleiotropic locus in the case of diploid population. Predator genotypes with different reproductive potential are unequally adapted to food resource limitation; therefore, the fitness of a predator’s genot...
Published in Russian Journal of Genetics
AbstractThe polymorphism of six nuclear genes, ACE (I/D, rs1799752), NOS3 (4b/4a, rs61722009), ADRA2B (I/D, rs28365031), MTHFR (С677Т, rs1801133), TCF7L2 (rs7903146), and CSK (rs1378942), as well as mitochondrial DNA, was examined in the population of Amur Evenks. It was demonstrated that among Evenks, Eastern Eurasian mtDNA haplogroups with the pr...
Published in Russian Journal of Genetics
AbstractFarber disease is a rare lysosomal storage disorder resulted from mutations in the ASAH1 gene codes acid ceramidase. The present study aimed to analyze the possible effect of amino acid substitutions caused by missense single nucleotide polymorphisms (SNP) on the acid ceramidase structure, stability and function via in silico. For this aim,...
Published in Russian Journal of Genetics
AbstractWe compared the frequencies of genotypes and alleles of the C3435T and C1236T polymorphisms of the multidrug resistance gene (ABCB1) among adolescents of the indigenous populations of North Asia: Tofalars, Evenks, Soyots. The sample included 86 people (Tofalars—26 people, Evenks—38, Soyots—22). The average age was 14 [12.5–15.5] years for S...
