Published in Russian Chemical Bulletin
Monoesters of tri- and tetraglycol and 1-pyrenecarboxylic acid were characterized for the first time by NMR spectroscopy and elemental analysis. The photophysical properties of the compounds obtained were studied. A selective sensory response of the esters to nitro-containing explosives in an aqueous medium was revealed. The maximum value of the St...
Published in Russian Chemical Bulletin
The results of studying electrochemical conversions of 7-R-3-X-1,2,4-triazolo[5,1-c][1,2,4]-triazin-4-ones (Triazavirin® and its derivatives) using cyclic voltammetry, chronoamperometry, and ESR spectroscopy are presented. The derivatives of 7-R-3-X-1,2,4-triazolo[5,1-c][1,2,4]-triazin-4-ones were found to be capable of electrochemical reducing in ...
Published in Russian Chemical Bulletin
We studied different approaches to the synthesis of polyfluoroalkyl-containing 1-methyl-4-nitrosopyrazoles, which are based on the cyclization of 4,4,4-trifluoro-3,3-dihydroxy-2-hydroxyimino-1-R-butan-1-ones or 2-hydroxyimino-1,3-diketones with methylhydrazine and on a one-pot sequential treatment of 1,3-diketones with sodium nitrite and methylhydr...
Published in Russian Chemical Bulletin
We present the results of a quantum chemical study of a series of tetrylenes (silylenes, germylenes, and stannylenes), aimed at identifying structural and electronic factors affecting the width of the HOMO—LUMO energy gap. Compounds considered in this work contain atoms of Group 14 elements in both di- and tricoordinate states due to additional tra...
Published in Russian Chemical Bulletin
This brief review highlights the history of the discovery of the phosphatase domain of human soluble epoxide hydrolase (sEH-P). The data on its structure and physiological role are summarized. State-of-the-art methods for the evaluation of the inhibitory activity of small molecules against sEH-P are described. The structures of endogenous substrate...
Published in Russian Chemical Bulletin
The condensation of 3-arylhydrazinylidenepentane-2,4-diones with hydrazine hydrate, 2-hydroxyethylhydrazine, benzylhydrazine hydrochloride, and 4-hydrazinylbenzenesulfonamide hydrochloride gave 4-aryldiazenyl-3,5-dimethylpyrazoles. An alternative route to the synthesis of N-substituted 4-aryldiazenylpyrazoles is based on the alkylation of NH-pyrazo...
Published in Russian Chemical Bulletin
The conditions for the homogeneous functionalization of polyepichlorohydrin (PECH) with thiourea by the “synthesis in gel” method were experimentally selected. The best solvent for this process is 1,4-dioxane. The reaction mixture visually represents a physical gel in the range of polymer concentrations from 6 to 20%. The composition of the product...
Published in Russian Chemical Bulletin
(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained via the reaction of 3-formyl-2-chloroquinoline with oxamic acid thiohydrazides.
Published in Russian Chemical Bulletin
A number of new 3-alkylthio-6-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]-tetrazines were synthesized and modified in nucleophilic substitution reactions with aliphatic amines. The study of the tuberculostatic activity of the compounds obtained revealed a number of active derivatives with a minimum inhibitory concentration of 0.37–3.1...
Published in Russian Chemical Bulletin
5,11-Dihydroindolo[3,2-b]carbazoles were for the first time modified with acceptor 1,2,4,5-tetrazine fragments. The photophysical and charge-transport properties of the synthesized donor-acceptor heterocyclic systems were studied. It was shown that the introduction of the 1,2,4,5-tetrazine moieties makes it possible to increase the hole and electro...
