Blervaque, Léo Préfaut, Christian Forthin, Hélène Maffre, Francis Bourrelier, Marion Héraud, Nelly Catteau, Matthias Pomiès, Pascal Jaffuel, Dany Molinari, Nicolas
...
Published in
Respiratory Research
BackgroundPulmonary rehabilitation (PR) improves exercise capacity, health-related quality of life (HRQoL) and dyspnea in chronic obstructive pulmonary disease (COPD) patients. Maintenance programs can sustain the benefits for 12 to 24 months. Yet, the long-term effects (> 12 months) of pragmatic maintenance programs in real-life settings remain un...
Gu, Yu Ye, Xianping Liu, Yuxiu Wang, Yu Shen, Kunlu Zhong, Jinjin Chen, Bilin Su, Xin
Published in
Respiratory Research
ObjectivesInvasive pulmonary aspergillosis (IPA) is increasingly reported in chronic obstructive pulmonary disease (COPD) patients. These patients often have poor clinical outcomes. Early recognition of IPA in COPD is always challenging. We aimed to develop and validate a risk model using readily available clinical parameters to predict IPA for acu...
Paulsson, Magnus Thelaus, Louise Riesbeck, Kristian Qvarfordt, Ingemar Smith, Margaretha E. Lindén, Anders Linder, Adam
Published in
Respiratory Research
ObjectivesVentilator-associated pneumonia (VAP) is difficult to diagnose using clinical criteria and no biomarkers have yet been proved to be sufficiently accurate. The use of the neutrophil-derived Heparin-binding protein (HBP) as a biomarker for pneumonia was investigated in this exploratory case–control study in two intensive care units at a ter...
Bai, Le Zhang, Li Pan, Tingyu Wang, Wei Wang, Dian Turner, Cassidy Zhou, Xianmei He, Hailang
Published in
Respiratory Research
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between di...
Wang, Sijiao Jiang, Zhilong Li, Liyang Zhang, Jun Zhang, Cuiping Shao, Changzhou
Published in
Respiratory Research
BackgroundRespiratory fungal exposure is known to be associated with various allergic pulmonary disorders. Eosinophils have been implicated in tissue homeostasis of allergic inflammation as both destructive effector cells and immune regulators. What contributions eosinophils have in Aspergillus fumigatus (Af)-induced allergic lung inflammation is w...
Gibson, Peter G. Prazma, Charlene M. Chupp, Geoffrey L. Bradford, Eric S. Forshag, Mark Mallett, Stephen A. Yancey, Steve W. Smith, Steven G. Bel, Elisabeth H.
Published in
Respiratory Research
BackgroundComorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe asthma. The aim of this analysis is to investigate the efficacy of mepolizumab in patients with severe eosinophilic asthma and comorb...
Andelid, Kristina Öst, Karolina Andersson, Anders Mohamed, Esha Jevnikar, Zala Vanfleteren, Lowie E. G. W. Göransson, Melker
Published in
Respiratory Research
BackgroundPatients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently, a causal link between mucus hyper-concentration and disease progression of CB has been suggested.MethodsIn this study, we have eva...
Park, Hye Jung Kim, Sae-Hoon Shin, Yoo Seob Park, Chul Hwan Cho, Eun-Suk Choi, Seung Joon Park, So Hyun Jung, Joo Hyun Kang, Il Gyu Lee, Myoung Seok
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Published in
Respiratory Research
BackgroundMost previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus,...
Budweiser, Stephan Baş, Şevki Jörres, Rudolf A. Engelhardt, Sebastian von Delius, Stefan Lenherr, Katharina Deerberg-Wittram, Jens Bauer, Andreas
Published in
Respiratory Research
BackgroundIn hospitalized patients with SARS-CoV-2 infection, outcomes markedly differ between locations, regions and countries. One possible cause for these variations in outcomes could be differences in patient treatment limitations (PTL) in different locations. We thus studied their role as predictor for mortality in a population of hospitalized...
Lee, Lisa K. Eghbali, Mansoureh Sapru, Anil
Published in
Respiratory Research
We identified a novel microRNA biomarker panel consisting of 6 microRNAs predicting mortality in pediatric acute respiratory distress syndrome patients. Each of the identified mRNA have potential mechanistic importance in acute respiratory distress syndrome and may lead to the development of pharmacologic targets.
