Bertelli, Fanny Suehs, Carey M. Mallet, Jean-Pierre Court-Fortune, Isabelle Gagnadoux, Frédéric Borel, Jean Christian Gaubert, Olivier Molinari, Nicolas Bourdin, Arnaud Jaffuel, Dany
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Published in
Respiratory Research
Background Whether the COVID-19 pandemic impacts Positive Airway Pressure (PAP) adherence over the long-term is unknown and only preliminary short-term data have been reported. Methods With the aim of describing the impact of the first and second waves of COVID-19 on PAP adherence during 2020 in France, we designed a cross-sectional study of Sleep-...
Cottin, Vincent Martinez, Fernando J. Jenkins, R. Gisli Belperio, John A. Kitamura, Hideya Molina-Molina, Maria Tschoepe, Inga Coeck, Carl Lievens, Dirk Costabel, Ulrich
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Published in
Respiratory Research
Background In the INBUILD trial in patients with progressive fibrosing interstitial lung diseases (ILDs), nintedanib reduced the rate of decline in forced vital capacity compared with placebo, with side-effects that were manageable for most patients. We used data from the INBUILD trial to characterize further the safety and tolerability of nintedan...
Colombo, Sebastiano Maria Scaravilli, Vittorio Cortegiani, Andrea Corcione, Nadia Guzzardella, Amedeo Baldini, Luca Cassinotti, Elisa Canetta, Ciro Carugo, Stefano Hu, Cinzia
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Published in
Respiratory Research
Few data exist about feasibility and safety of HFNC outside the ICU. This study retrospectively evaluates safety, feasibility and efficacy of HFNC used in general wards under intensivist-supervision and specific training courses. 150 patients with mild-moderate ARF admitted to general wards were included. HFNC demonstrated to be feasible and potent...
Liu, Yaling Wang, Xiaodong Li, Peiying Zhao, Yanhua Yang, Liqun Yu, Weifeng Xie, Hong
Published in
Respiratory Research
Schimmelpennink, M. C. Meek, D. B. Vorselaars, A. D. M. Langezaal, L. C. M. van Moorsel, C. H. M. van der Vis, J. J. Veltkamp, M. Grutters, J. C.
Published in
Respiratory Research
Background Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis. To date, little is known about this progressive fibrosing phenotype in sarcoidosis. Diffusion ...
Cifuentes, Erika Alejandra Sierra, Maria A. Yepes, Andrés Felipe Baldión, Ana Margarita Rojas, José Antonio Álvarez-Moreno, Carlos Arturo Anzola, Juan Manuel Zambrano, María Mercedes Huertas, Monica G.
Published in
Respiratory Research
Background Studies of the respiratory tract microbiome primarily focus on airway and lung microbial diversity, but it is still unclear how these microbial communities may be affected by intubation and long periods in intensive care units (ICU), an aspect that today could aid in the understanding of COVID19 progression and disease severity. This stu...
Hong, Yueling Deng, Min Hu, Wenhui Zhang, Rui Jiang, Lei Bai, Linfu Duan, Jun
Published in
Respiratory research
Cough strength is associated with short-term outcome in patients with scheduled extubation who successfully complete a spontaneous breathing trial (SBT). However, the long-term outcome is unclear. This was a prospective observational study performed in a respiratory ICU of a teaching hospital. COPD patients who successfully completed a SBT were can...
Imani, Jewel Bodine, Steven P M Lamattina, Anthony M Ma, Diane D Shrestha, Shikshya Maynard, Dawn M Bishop, Kevin Nwokeji, Arinze Malicdan, May Christine V Testa, Lauren C
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Published in
Respiratory research
Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by improper biogenesis of lysosome-related organelles (LROs). Lung fibrosis is the leading cause of death among adults with HPS-1 and HPS-4 genetic types, which are associated with defects in the biogenesis of lysosome-related organelles complex-3 (BLOC-3), a guanine e...
Le, Nguyen Phuong Khanh do Nascimento, Amanda Florentina Schneberger, David Quach, Chi Cuong Zhang, Xiaobei Aulakh, Gurpreet K. Dawicki, Wojciech Liu, Lixin Gordon, John R. Singh, Baljit
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Published in
Respiratory Research
Background Asthma is a major cause of morbidity and mortality in humans. The mechanisms of asthma are still not fully understood. Leukocyte-specific protein-1 (LSP-1) regulates neutrophil migration during acute lung inflammation. However, its role in asthma remains unknown. Methods An OVA-induced mouse asthma model in LSP1-deficient (Lsp1−/−) and w...
Marin-Oto, Marta Sanz-Rubio, David Santamaría-Martos, Fernando Benitez, Ivan Simon, Ana L. Forner, Marta Cubero, Pablo Gil, Ana Sanchez-de-laTorre, Manuel Barbe, Ferran
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Published in
Respiratory Research
Background Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma levels of sRAGE were measured in 317 subjects at baseline (57 heathy nonsmokers [HNS],...
