Krempaska, Kristina Barnowski, Sandra Gavini, Jacopo Hobi, Nina Ebener, Simone Simillion, Cedric Stokes, Andrea Schliep, Ronja Knudsen, Lars Geiser, Thomas K.
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Published in
Respiratory Research
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy cells are well known and drug response can be different between cells isolated from IPF patients and controls. The macrolide Azithromycin (AZT) has anti-inflam...
Shen, Yanfei Cai, Guolong Chen, Shangzhong Hu, Caibao Yan, Jing
Published in
Respiratory Research
BackgroundAcute respiratory distress syndrome (ARDS), a complex response to various insults, has a high mortality rate. As pulmonary edema resulting from increased vascular permeability is a hallmark of ARDS, management of the fluid status, including the urine output (UO) and fluid intake (FI), is essential. However, the relationships between UO, F...
Perea, Lídia Rodrigo-Troyano, Ana Cantó, Elisabet Domínguez-Álvarez, Marisol Giner, Jordi Sanchez-Reus, Ferran Villar-García, Judit Quero, Sara García-Núñez, Marian Marín, Alicia
...
Published in
Respiratory Research
BackgroundFor still unclear reasons, chronic airway infection often occurs in patients with Chronic Obstructive Pulmonary Disease (COPD), particularly in those with more severe airflow limitation. Fatty-acid binding protein 4 (FABP4) is an adipokine involved in the innate immune response against infection produced by alveolar macrophages (Mɸ). We h...
Vogelberg, Christian Goldstein, Stanley Graham, LeRoy Kaplan, Alan de la Hoz, Alberto Hamelmann, Eckard
Published in
Respiratory Research
Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment to add onto inhaled corticosteroids (ICS) in children and adolescents with asthma who remain symptomatic despite ICS can be difficult. This l...
Jiang, Jun-xia Shen, Hui-juan Guan, Yan Jia, Yong-liang Shen, Jian Liu, Qi Xie, Qiang-min Yan, Xiao-feng
Published in
Respiratory Research
Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the need for early and specific therapeutic interventions. The arachidonic acid cytochrome P-450 (CYP) pathway h...
Ko, Ryoung-Eun Lee, Jin Gu Kim, Song Yee Kim, Young Tae Choi, Sun Mi Kim, Do Hyung Cho, Woo Hyun Park, Seung-Il Jo, Kyung-Wook Kim, Hong Kwan
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Published in
Respiratory Research
BackgroundThe use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation ...
Zheng, Zhongjun Jiang, Libing Zhang, Song Guervilly, Christophe Zhang, Mao Feng, Xia Ding, Jianbo
Published in
Respiratory Research
BackgroundsThe aim of this study is investigating the benefits and harms of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS).MethodsWe comprehensively searched PubMed, EMBASE, and Cochrane library for randomized controlled trials comparing NMBAs to any other comparator. We pooled data using relative ...
Artaraz, Amaia Crichton, Megan L. Finch, Simon Abo-Leyah, Hani Goeminne, Pieter Aliberti, Stefano Fardon, Thomas Chalmers, James D.
Published in
Respiratory Research
BackgroundRecurrent bronchiectasis exacerbations are related to deterioration of lung function, progression of the disease, impairment of quality of life, and to an increased mortality. Improved detection of exacerbations has been accomplished in chronic obstructive pulmonary disease through the use of patient completed diaries. These tools may enh...
Liao, Yifang Li, Ping Wang, Yanxia Chen, Hong Ning, Shangwei Su, Dongju
Published in
Respiratory Research
BackgroundAsthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is little known about the profiles of long non-coding RNA and the long non-coding RNA related competing endogenous RNA network in asthma...
Long, Gabriella H. Southworth, Thomas Kolsum, Umme Donaldson, Gavin C. Wedzicha, Jadwiga A. Brightling, Christopher E. Singh, Dave
Published in
Respiratory Research
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of
