Martinez, Fernando J. Lipworth, Brian J. Rabe, Klaus F. Collier, David J. Ferguson, Gary T. Sethi, Sanjay Feldman, Gregory J. O’Brien, Gerald Jenkins, Martin Reisner, Colin
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Published in
Respiratory Research
BackgroundThe Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting bronchodilator for chronic obstructive pulmonary disease (COPD). Here we present a pre-specified pooled analysis of PINNACLE-1, PINNACLE-2, and PINNACLE-4.MethodsPINNACLE-1, -2, and -4 we...
Bingula, Rea Filaire, Edith Molnar, Ioana Delmas, Eve Berthon, Jean-Yves Vasson, Marie-Paule Bernalier-Donadille, Annick Filaire, Marc
Published in
Respiratory Research
BackgroundWhile well-characterised on its molecular base, non-small cell lung cancer (NSCLC) and its interaction with local microbiota remains scarcely explored. Moreover, current studies vary in source of lung microbiota, from bronchoalveolar lavage fluid (BAL) to tissue, introducing potentially differing results. Therefore, the objective of this ...
Liu, Dehan Zhang, Wanshu Pan, Feng Li, Lin Yang, Lian Zheng, Dandan Wang, Jiazheng Liang, Bo
Published in
Respiratory Research
BackgroundA cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at each time point, to explore the relevant affecting factors, and to describe the chest CT findings at different time points after hos...
Ghosh, Nilanjana Choudhury, Priyanka Kaushik, Sandeep Rai Arya, Rakesh Nanda, Ranjan Bhattacharyya, Parthasarathi Roychowdhury, Sushmita Banerjee, Rintu Chaudhury, Koel
Published in
Respiratory Research
BackgroundAsthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging for the clinicians. They exhibit a higher burden in terms of both mortality and morbidity in comparison to patients with only asthma ...
Wu, Jinzhun Ge, Dandan Zhong, Taoling Chen, Zuojia Zhou, Ying Hou, Lingyun Lin, Xiaoliang Hong, Jiaxu Liu, Kuai Qi, Hui
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Published in
Respiratory Research
BackgroundParticulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respiratory system and the regulators of the immunogenicity of PM is not fully elucidated.MethodsTo identify the potential effector of PM e...
Xanthouli, Panagiota Koegler, Maria Marra, Alberto M. Benjamin, Nicola Fischer, Lukas Eichstaedt, Christina A. Harutyunova, Satenik Nagel, Christian Grünig, Ekkehard Egenlauf, Benjamin
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Published in
Respiratory Research
BackgroundThe objective of this study was to analyze prognostic factors and risk stratification in patients with pulmonary arterial hypertension (PAH) and comorbidities.MethodsPatients with invasively diagnosed PAH were included in the analysis. Comorbidities were clinically diagnosed as proposed in the 6th World Symposium of pulmonary hypertension...
Birk, Gerald Kästle, Marc Tilp, Cornelia Stierstorfer, Birgit Klee, Stephan
Published in
Respiratory Research
BackgroundOne of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated threshold-based segmentation and subsequent quantification of severely damaged lungs requires visual inspection and manual correction...
van ’t Hul, Alex J. Koolen, Noortje H. van Hees, Jeroen W. van den Borst, Bram Spruit, Martijn A.
Published in
Respiratory Research
An amendment to this paper has been published and can be accessed via the original article.
Gilfillan, Margaret Das, Pragnya Shah, Dilip Alam, Mohammad Afaque Bhandari, Vineet
Published in
Respiratory Research
An amendment to this paper has been published and can be accessed via the original article.
Kiss, Edit Abdelwahab, El Husseiny Mohamed Mahmud Steib, Anita Papp, Emoke Torok, Zsofia Jakab, Laszlo Smuk, Gabor Sarosi, Veronika Pongracz, Judit Erzsebet
Published in
Respiratory Research
BackgroundThe predominant metastatic site of lung cancer (LC) is the brain. Although outdated, conventional cisplatin treatment is still the main therapeutic approach for patients with advanced non-small cell lung cancer (NSCLC), since targeted therapy that offers better tumor control is not always possible. In the present study brain metastasis as...
