El Shehaby, Doaa M El-Mahdy, Reham I Ahmed, Asmaa M Hosny, Ahmed Abd El-Rady, Nessren M
Published in
Reproductive toxicology (Elmsford, N.Y.)
Ketamine, a dissociative anesthetic, recently has spread as a recreational drug. Its abuse lead to neurobehavioral disturbance in addition to toxic effects on other body organs. To evaluate the toxic effects of chronic administration of low ketamine doses on the memory, testicles, and erection, explore its pathophysiology through oxidative stress m...
Wang, Lingling Yan, Ming Wu, Siwen Wu, Xiaolong Bu, Tiao Wong, Chris K C Ge, Renshan Sun, Fei Cheng, C Yan
Published in
Reproductive toxicology (Elmsford, N.Y.)
Actin cytoskeleton is crucial to support spermatogenesis in the mammalian testis. However, the molecular mechanism(s) underlying changes of actin cytoskeletal organization in response to cellular events that take place across the seminiferous epithelium (e.g., self-renewal of spermatogonial stem cells, germ cell differentiation, meosis, spermiogene...
Al-Kawlani, Boodor Murrieta-Coxca, José Martin Chaiwangyen, Wittaya Fröhlich, Karolin Fritzsche, Andreas Winkler, Simone Markert, Udo R Morales-Prieto, Diana M
Published in
Reproductive toxicology (Elmsford, N.Y.)
Doxorubicin (DOX) is one of the most commonly used drugs for the treatment of childhood cancers, including leukemia and lymphomas. Despite the high survival rate, female leukemia survivors are at higher risk of ovarian failure and infertility later in life. Treatment with chemotherapeutic drugs like DOX is associated with damage in ovarian follicle...
Yu, Ying Shi, Zhaokun Xu, Dan Li, Ying Qin, Jun Zhang, Zhaohui Wang, Hui
Published in
Reproductive toxicology (Elmsford, N.Y.)
Epidemiological investigations have found that maternal alcohol intake increases the risk of mental illness in offspring. Our study investigated changes of depression- and anxiety-like behaviors in adult offspring caused by prenatal ethanol exposure (PEE) and explored the potential mechanism. After Wistar rats were intragastrically administered eth...
Erthal, Rafaela Pires Staurengo-Ferrari, Larissa Fattori, Victor Luiz, Karen Gomes Cunha, Fernando Queiroz Pescim, Rodrigo Rosseto Cecchini, Rubens Verri, Waldiceu Aparecido Jr Guarnier, Flavia Alessandra Alves Fernandes, Glaura Scantamburlo
...
Published in
Reproductive toxicology (Elmsford, N.Y.)
Malathion is an organophosphate insecticide used in agriculture and for controlling vector-borne diseases such as Zika. Humans can be exposed to malathion by means of ingestion of contaminated food. The juvenile and peripubertal periods are a large window of vulnerability to the action of toxic agents. The aim of the present study was to evaluate t...
Chiangsaen, Petcharat Maneesai, Putcharawipa Kukongviriyapan, Upa Tong-Un, Terdthai Ishida, Wannapa Prachaney, Parichat Pakdeechote, Poungrat
Published in
Reproductive toxicology (Elmsford, N.Y.)
Tangeretin is a polymethoxyflavone concentrated in citrus peels and has several biological activities. This study examined whether tangeretin improved reproductive dysfunction in Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Male Sprague-Dawley rats received L-NAME to induce hypertension and reproductive dysfunc...
Jinno, Naoko Furugen, Ayako Kurosawa, Yuko Kanno, Yuki Narumi, Katsuya Kobayashi, Masaki Iseki, Ken
Published in
Reproductive toxicology (Elmsford, N.Y.)
The use of valproic acid (VPA), an antiepileptic drug, during pregnancy, is known to increase various fetal risks. Since VPA has been known to inhibit histone deacetylases (HDACs); its administration could alter gene transcription levels. However, in vivo effects of VPA administration on placental transporters have not been fully elucidated. The pu...
Adams, Samantha Wiersielis, Kimberly Yasrebi, Ali Conde, Kristie Armstrong, Laura Guo, Grace L Roepke, Troy A
Published in
Reproductive toxicology (Elmsford, N.Y.)
After the phase-out of polybrominated diphenyl ethers, their replacement compounds, organophosphate flame retardants (OPFRs) became ubiquitous in home and work environments. OPFRs, which may act as endocrine disruptors, are detectable in human urine, breast milk, and blood samples collected from pregnant women. However, the effects of perinatal OPF...
Chetot, Thomas Taufana, Shira Benoit, Etienne Lattard, Virginie
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Reproductive toxicology (Elmsford, N.Y.)
Vitamin K antagonists (VKA) are not recommended during pregnancy because warfarin (a first-generation VKA) is associated with a malformation syndrome "the fetal warfarin syndrome" (FWS). VKA are also used for rodent management worldwide. Recently, the Committee for Risk Assessment responsible for the European chemical legislation for advances on th...
McDonald, Jasmine A Cirillo, Piera M Tehranifar, Parisa Krigbaum, Nickilou Y Engmann, Natalie J Cohn, Barbara A Terry, Mary Beth
Published in
Reproductive toxicology (Elmsford, N.Y.)
We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p'-DDT, p,p'-DDT, and p,p'-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. We focused our analyses on o,p'-DDT exposure given our previous report of a positive association between intrauteri...
