Leke, Aminkeng Zawuo Dolk, Helen Loane, Maria Casson, Karen Nelen, Vera Barišić, Ingeborg Garne, Ester Rissman, Anke O'Mahony, Mary Neville, Amanda J
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Published in
Reproductive toxicology (Elmsford, N.Y.)
This study investigated the risk of congenital heart defects (CHD) and other congenital anomalies (CA) associated with first trimester use of macrolide antibiotics (mainly erythromycin, spiramycin, clarithromycin and azithromycin) and lincosamides (clindamycin) using a case-malformed control design. Data included 145,936 babies with a CA diagnosis ...
Liu, Heze Liu, Liang Han, Hui Liu, Kexin Wang, Hui
Published in
Reproductive toxicology (Elmsford, N.Y.)
The panel of suitable reference genes in the fetal liver have not been reported. In this study, five commonly used reference genes (GAPDH, β-actin, Rn18 s, Rpl13a, and Rps29) were firstly selected as candidates. Bestkeeper, GeNorm, and NormFinder software were then used to screen out the panel of suitable reference genes of male and female fetal ra...
Gounden, Verena Warasally, Mohamed Zain Magwai, Thabo Naidoo, Rajen Chuturgoon, Anil
Published in
Reproductive toxicology (Elmsford, N.Y.)
Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathology. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs. Third-trimester serum maternal sa...
Diaz-Cueto, Laura Dominguez-Lopez, Pablo Paniagua, Lucero Martinez-Quezada, Rebeca Arechavaleta-Velasco, Fabian
Published in
Reproductive toxicology (Elmsford, N.Y.)
Preeclampsia and intrauterine growth restriction, multisystemic disorders characterized by a shallow trophoblast invasion, have been associated with maternal cadmium (Cd) exposure. The molecular mechanisms of this association remain unknown. Cell adhesion and matrix metalloproteinase production are essential for an adequate trophoblast invasion. Th...
Rager, Julia E Bangma, Jacqueline Carberry, Celeste Chao, Alex Grossman, Jarod Lu, Kun Manuck, Tracy A Sobus, Jon R Szilagyi, John Fry, Rebecca C
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Published in
Reproductive toxicology (Elmsford, N.Y.)
Environmental chemicals comprise a major portion of the human exposome, with some shown to impact the health of susceptible populations, including pregnant women and developing fetuses. The placenta and cord blood serve as important biological windows into the maternal and fetal environments. In this article we review how environmental chemicals (d...
Behl, Mamta Willson, Cynthia J Cunny, Helen Foster, Paul M D McIntyre, Barry Shackelford, Cynthia Shockley, Keith R McBride, Sandra Turner, Katie Waidyanatha, Suramya
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Published in
Reproductive toxicology (Elmsford, N.Y.)
The general population, including children and adolescents, is exposed to 4-methylimidazole (4-MI) in the diet. 4-MI is a by-product of caramel color manufacturing. It has been previously classified as a possible human carcinogen and displays potential reproductive toxicity. A follow up assessment of reproductive toxicity was conducted in rats util...
Han, Hui Liu, Liang Chen, Ming Liu, Yi Wang, Hui Chen, Liaobin
Published in
Reproductive toxicology (Elmsford, N.Y.)
Quantitative real-time polymerase chain reaction (qRT-PCR) is a powerful tool for evaluating gene expression, but its accuracy is affected by the stability of the reference genes used for normalization. The Minimum Information for Publication of Quantitative Real-time PCR Experiments (MIQE) guidelines indicated that it was important to use multiple...
Saito, Hirokatsu Hara, Kenshiro Kitajima, Satoshi Tanemura, Kentaro
Published in
Reproductive toxicology (Elmsford, N.Y.)
Vitamin E (VE) plays numerous important roles in mammals because of its antioxidant activity. As a result, VE deficiency (VED) leads to the dysfunction of central nervous, reproductive, and immune systems. However, few studies have reported the effects of VED on the male reproductive system. In this study, we investigated the effects of VED on male...
Armengaud, J B Yzydorczyk, C Siddeek, B Peyter, A C Simeoni, U
Published in
Reproductive toxicology (Elmsford, N.Y.)
Intrauterine growth restriction (IUGR) affects 10 to 15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic or placental cause. IUGR reflects an abnormal adaptive fetal growth in a deleterious environment. Individuals bor...
Zhang, Xiaoning Chen, Chen Zhong, Yuanyuan Zeng, Xuhui
Published in
Reproductive toxicology (Elmsford, N.Y.)
Triptonide reportedly has strong antitumor and anti-inflammatory activities. However, its severe toxicity, including to the reproductive system, has greatly restricted its use in patients who wish to preserve fertility. lncRNAs play crucial roles in male fertility and reportedly regulate triptonide's antitumor activity. However, whether lncRNAs are...
