Thakur, Mili Rambhatla, Anupama Qadri, Farnoosh Chatzicharalampous, Charalampos Awonuga, Modupe Saed, Ghassan Diamond, Michael P. Awonuga, Awoniyi O.
Published in
Reproductive Sciences
Adhesions are permanent fibrovascular bands between peritoneal surfaces, which develop following virtually all body cavity surgeries. The susceptibility to develop, and the severity, of adhesions following intra-abdominal surgery varies within and between individuals, suggesting that heritable factors influence adhesion development. In this manuscr...
Hsu, Albert L. Finlinson, Alex Warncke, Kristen
Published in
Reproductive Sciences
The COVID-19 pandemic is unlike anything we have experienced in over a century. In the USA, waves of COVID-19 have migrated from the Northeast to the Sun Belt to the Midwest over the past year. Compared with females, males are more susceptible to SARS-CoV-2 infection, have more severe COVID-19 disease, and have higher death rates. In many countries...
Liu, Lou Xu, Han-Jie Chen, Jia-Le Chen, Zhong Zhan, Hui-Ying Xu, De-Xiang Chen, Yu Xu, Zheng-Feng Chen, Dao-Zhen
Published in
Reproductive Sciences
Premature rupture of membranes (PROM) is usually associated with pregnant and neonatal complications. Most of the PROM cases are caused by ascending asymptomatic genital infection. In China, PROM (15.3%) is more common than spontaneous preterm labor (7.3%) and leads to more adverse pregnancy outcomes. Here, we designed a prospective cohort study to...
Yim, Peter D. Hyuga, Shunsuke Wu, Amy D. Dan, William Vink, Joy Y. Gallos, George
Published in
Reproductive Sciences
Spontaneous preterm birth (sPTB) remains a worldwide healthcare challenge. Preterm labor (PTL) is thought to be the largest reversible cause of sPTB, but current tocolytic therapies are ineffective and associated with systemic side effects from chronic use. Therefore, identifying novel mechanisms that promote human uterine smooth muscle (hUSM) rela...
Neal, Adam S Nunez, Miguel Lai, Tiffany Tosevska, Anela Morselli, Marco Amneus, Malaika Zakhour, Mae Moatamed, Neda A Pellegrini, Matteo Memarzadeh, Sanaz
...
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Progesterone therapy is a viable treatment for complex atypical hyperplasia (CAH) and endometrial adenocarcinoma, though reliable molecular determinants of response are not available. To explore if analysis of pre-therapy endometrial biopsies could yield biomarkers of response to progesterone, patients with CAH or adenocarcinoma undergoing treatmen...
Ginsberg, Yuval Gutzeit, Ola Hadad, Salim Divon, Michael Y. Khatib, Nizar Fainaru, Ofer Weiner, Zeev Beloosesky, Ron
Published in
Reproductive Sciences
Maternal natural vaginal progesterone (nVP) administration has been shown to reduce the risk of preterm birth (PTB). The largest randomized trial of nVP for PTB (OPPTIMUM) noted a sonographic reduction in neonatal brain injury following nVP treatment. We investigated the neuroinflammatory protective effect of maternal nVP in a mouse model for mater...
Underhill, Lori A Avalos, Nora Tucker, Richard Zhang, Zheng Messerlian, Geralyn Lechner, Beatrice
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Preterm birth is a leading cause of neonatal mortality in the US and globally, with preterm premature rupture of fetal membranes (PPROM) accounting for one third of preterm births. Currently no predictive diagnostics are available to precisely assess risk and potentially reduce the incidence of PPROM. Bigycan and decorin, the main proteoglycans pre...
Dutta, Sulagna Sengupta, Pallav
Published in
Reproductive sciences (Thousand Oaks, Calif.)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on 11th March 2020. Bulk of research on this virus are carried out to unveil its multivariate pathology. Surprisingly, men are reportedly more vulnerable to COVID-19 eve...
Bosaeus, Marja Andersson-Hall, Ulrika Andersson, Louise Karlsson, Therese Ellegård, Lars Holmäng, Agneta
Published in
Reproductive sciences (Thousand Oaks, Calif.)
The Pregnancy Obesity Nutrition and Child Health study is a longitudinal study of reproductive health. Here we analyzed body composition of normal-weight and obese Swedish women by three methods during each trimester of pregnancy. Cross-sectional and longitudinal fat mass estimates using quantitative magnetic resonance (QMR) and bioelectrical imped...
Hudson, Quanah J. Ashjaei, Kazem Perricos, Alexandra Kuessel, Lorenz Husslein, Heinrich Wenzl, Rene Yotova, Iveta
Published in
Reproductive Sciences
Endometriosis is a chronic inflammatory disease associated with an impaired immune response at the site of lesion implantation. The ability of macrophages to respond to changes in their environment is critical for an effective immune response. However, the existing knowledge of the peritoneal immune cell populations, their activation state and cont...