Sethuram, Ramya Bai, David Abu-Soud, Husam M
Published in
Reproductive sciences (Thousand Oaks, Calif.)
COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups. Given the established roles of zinc in combating oxidative damage and viral infections, zinc is being trialed as a treatment modality against COVID-19. Zinc also has confirmed roles in both male and female repro...
Dcunha, Reyon Hussein, Reda S Ananda, Hanumappa Kumari, Sandhya Adiga, Satish Kumar Kannan, Nagarajan Zhao, Yulian Kalthur, Guruprasad
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Reproductive sciences (Thousand Oaks, Calif.)
Spermatozoon is a motile cell with a special ability to travel through the woman's reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa should possess progressive motility. Therefore, motility is an important parameter during both natural and assisted conception. The global trend of progressive reduction in the...
Li, Dan Zheng, Lianwen Zhao, Donghai Xu, Ying Wang, Yeling
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Reproductive sciences (Thousand Oaks, Calif.)
Recurrent spontaneous abortion affects approximately 1-2% of women of childbearing, and describes a condition in which women suffer from three or more continuous spontaneous miscarriages. However, the origin of recurrent spontaneous abortion (RSA) remains unknown, preventing effective treatment and placing stress upon patients. It has been acknowle...
Selvaraj, Kaviya Ravichandran, Sowbarnika Krishnan, Sushmita Radhakrishnan, Risna Kanjirassery Manickam, Nivethitha Kandasamy, Mahesh
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Reproductive sciences (Thousand Oaks, Calif.)
Coronavirus disease 2019 (COVID-19), which resulted from the pandemic outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a massive inflammatory cytokine storm leading to multi-organ damage including that of the brain and testes. While the lungs, heart, and brain are identified as the main targets of SARS-CoV-2-medi...
Jahmani, M Y Hammadeh, M E Al Smadi, M A Baller, Marko K
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Reproductive sciences (Thousand Oaks, Calif.)
Chromatin condensation is one of the main factors essential for sperm function. Evaluation of chromatin condensation by current methods render the assessed sperm unsuitable for assisted reproduction. We examined the Raman spectra of normal morphology sperm to determine whether a non-invasive confocal Raman spectroscopy can detect spectral differenc...
Mecacci, F Avagliano, L Lisi, F Clemenza, S Serena, Caterina Vannuccini, S Rambaldi, M P Simeone, S Ottanelli, S Petraglia, F
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Published in
Reproductive sciences (Thousand Oaks, Calif.)
In recent years, a growing interest has arisen regarding the possible relationship between adverse pregnancy outcomes (APOs) and inadequate maternal hemodynamic adaptations to the pregnancy. A possible association between "placental syndromes," such as preeclampsia (PE) and fetal growth restriction (FGR), and subsequent maternal cardiovascular dise...
Singh, Bhuchitra Sims, Holly Trueheart, Irene Simpson, Khara Wang, Karen C Patzkowsky, Kristin Wegman, Thomas Soma, Jean-Marie Dixon, Rosina Jayes, Friederike
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Reproductive sciences (Thousand Oaks, Calif.)
Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo for effects on uterine fibroids. The objective was to assess the safety and tolerability of c...
Pretzel, Shannon Kuhn, Katherine Pal, Lubna Polotsky, Alex Taylor, Hugh S. Zhang, Heping Robins, Jared Young, Steven L. Santoro, Nanette
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Reproductive Sciences
The Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis (PREGnant) Trial (clinicaltrials.gov no. NCT04173169) was designed to test the hypothesis that 60-day pre-treatment with an oral GnRH antagonist in women with documented endometriosis and planning an IVF cycle will result in a superior live birth rate to placebo. Eight hundred...
Qi, Tingting Zhang, Di Shi, Xuting Li, Minhui Xu, Hongbin
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Reproductive sciences (Thousand Oaks, Calif.)
Preeclampsia (PE) is a common obstetric disease and a major cause of maternal, newborn, and fetal death. This condition is a multisystem disorder characterized by hypertension, proteinuria, and involvement of the kidney, liver, and nervous system. It is generally believed that the placenta is the main cause of PE. circRNAs are a special class of no...
Salian, Sujith Raj Pandya, Riddhi Kirit Laxminarayana, Sindhura Lakshmi Koulmane... Krishnamurthy, Hanumantappa Cheredath, Aswathi Tholeti, Prathima Uppangala, Shubhashree Kalthur, Guruprasad Majumdar, Subeer Schlatt, Stefan
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Published in
Reproductive sciences (Thousand Oaks, Calif.)
Cryopreservation of immature-testicular-tissue (ITT) prior to gonadotoxic treatment, while experimental, is the only recommended option for fertility preservation in prepubertal boys. The handling and manipulation of ITT before cryopreservation could influence the functionality of cells during fertility restoration, which this study explored by eva...
