Lu, Chen-Chen Wang, Gui-Hua Lu, Jian Chen, Pei-Pei Zhang, Yang Hu, Ze-Bo Ma, Kun-Ling
Published in
Renal Fibrosis: Mechanisms and Therapies
Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to a living environment of various stresses and pathological stimuli, podocytes are prone to injuries; moreover, as a cell without proliferative potential, loss of podocytes is vital in the pathogenesis of glomerulosclerosis. Thus, sufficient understanding of f...
Zhang, Ying-Ying Yu, Ying Yu, Chen
Published in
Renal Fibrosis: Mechanisms and Therapies
The rennin–angiotensin–aldosterone system (RAAS) has been well documented in regulating blood pressure, fluid volume, and sodium balance. Overactivity of RAAS promotes both systemic and regional glomerular capillary hypertension, which could induce hemodynamic injury to the glomerulus, leading to kidney damage and renal fibrosis via profibrotic and...
