Tzounakas, Vassilis L Anastasiadi, Alkmini T Arvaniti, Vasiliki-Zoi Lelli, Veronica Fanelli, Giuseppina Paronis, Efthymios C Apostolidou, Anastasia C Balafas, Evangelos G Kostomitsopoulos, Nikolaos G Papageorgiou, Effie G
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Published in
Redox biology
Redox imbalance and oxidative stress have emerged as generative causes of the structural and functional degradation of red blood cells (RBC) that happens during their hypothermic storage at blood banks. The aim of the present study was to examine whether the antioxidant enhancement of stored RBC units following uric (UA) and/or ascorbic acid (AA) s...
Jelleschitz, Julia Zhang, Yuyu Grune, Tilman Chen, Weixuan Zhao, Yihang Jia, Mengzhen Wang, Yajie Liu, Zhigang Höhn, Annika
Published in
Redox biology
Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation of energy metabolism. Over the decades, research has long focused on the beneficial effects of methionine supplementation, while data on positive effects of methionine restriction (MR) were first published in 1993. MR is a low-methionine dietary int...
Li, Lihua Wang, Kunpeng Jia, Rongjun Xie, Jing Ma, Liman Hao, Zhiqing Zhang, Weiwei Mo, Jinggang Ren, Fu
Published in
Redox biology
Chronic liver injury causing liver fibrosis is a major cause of morbidity and mortality worldwide. Targeting the suppression of hepatic stellate cell (HSC) activation is recognized as an effective strategy for the treatment of liver fibrosis. Ellagic acid (EA), a natural polyphenol product isolated from fruits and vegetables, possesses many biologi...
Arbogast, Sandrine Kotzur, Heinrich Frank, Corinna Compagnone, Nathalie Sutra, Thibault Pillard, Fabien Pietri, Sylvia Hmada, Nisrine Moussa, Daouda Moustapha Abba Bride, Jamie
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Published in
Redox biology
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder characterized by progressive muscle weakness. Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD skeletal muscle biopsies. However, its role in FSHD is unclear. In this study, we evaluated ANT1 ...
Ferrara, Francesca Cordone, Valeria Pecorelli, Alessandra Benedusi, Mascia Pambianchi, Erika Guiotto, Anna Vallese, Andrea Cervellati, Franco Valacchi, Giuseppe
Published in
Redox biology
NLRP1 is one of the major inflammasomes modulating the cutaneous inflammatory responses and therefore linked to a variety of cutaneous conditions. Although NLRP1 has been the first inflammasome to be discovered, only in the past years a significant progress was achieved in understanding the molecular mechanism and the stimuli behind its activation....
Rius-Pérez, Sergio Pérez, Salvador Toledano, Michel B Sastre, Juan
Published in
Redox biology
Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis. Late during the course of pancreatitis, p53 was localized in mitochondria of pancreatic cells undergoing necroptosis. In mice lacking p53, necroptosis was ...
Xie, Yinyin Zhang, Yannan Sun, Aina Peng, Yamei Hou, Weikang Xiang, Cong Zhang, Guoxin Lai, Beibei Hou, Xiaoshuang Zheng, Fangfang
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Published in
Redox biology
The regulation of mitochondria function and health is a central node in tissue maintenance, ageing as well as the pathogenesis of various diseases. However, the maintenance of an active mitochondrial functional state and its quality control mechanisms remain incompletely understood. By studying mice with a mitochondria-targeted reporter that shifts...
Chen, Jingshu Tang, Shu Ke, Sui Cai, James J Osorio, Daniel Golovko, Andrei Morpurgo, Benjamin Guo, Shaodong Sun, Yuxiang Winkle, Melanie
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Published in
Redox biology
The metastasis-associated lung adenocarcinoma transcript1 (MALAT1) is a long noncoding RNA (lncRNA) and is known for its role in cancer development and prognosis. In this study, we report that MALAT1 plays an important role in regulating acute inflammatory responses in sepsis. In patient samples, MALAT1 expression was positively correlated with sev...
Nogueira, Renato C Minnion, Magdalena Clark, Anna D Dyson, Alex Tanus-Santos, José E Feelisch, Martin
Published in
Redox biology
In blood, the majority of endothelial nitric oxide (NO) is scavenged by oxyhemoglobin, forming nitrate while a small part reacts with dissolved oxygen to nitrite; another fraction may bind to deoxyhemoglobin to generate nitrosylhemoglobin (HbNO) and/or react with a free cysteine to form a nitrosothiol. Circulating nitrite concentrations in healthy ...
Nagasaki, Taisei Maeda, Hitoshi Taguchi, Kazuaki Yanagisawa, Hiroki Nishida, Kento Kobayashi, Kazuki Wada, Naoki Noguchi, Isamu Murata, Ryota Sakai, Hiromi
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Published in
Redox biology
Renal ischemia-reperfusion (IR)-induced tissue hypoxia causes impaired energy metabolism and oxidative stress. These conditions lead to tubular cell damage, which is a cause of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD). Three key molecules, i.e., hypoxia-inducible factor-1α (HIF-1α), AMP-activated protein kinase (AMPK), and ...
