Wang, Jia-Nan Yang, Qin Yang, Chen Cai, Yu-Ting Xing, Tian Gao, Li Wang, Fang Chen, Xin Liu, Xue-Qi He, Xiao-Yan
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Published in
Redox biology
The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, the prevention of AKI in diabetic nephropathy is feasible and of value. As we detected highly activation of TGF-β/Smad3 signaling in both human biopsy and mouse model of diabetic nephropathy, we hypothes...
Vitturi, Dario A Maynard, Charles Olsufka, Michele Straub, Adam C Krehel, Nick Kudenchuk, Peter J Nichol, Graham Sayre, Michael Kim, Francis Dezfulian, Cameron
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Published in
Redox biology
Brain and heart injury cause most out-of-hospital cardiac arrest deaths but limited pharmacotherapy exists to protect these tissues. Nitrite is a nitric oxide precursor that is protective in pre-clinical models of ischemic injury and safe in Phase I testing. Protection may occur by cGMP generation via the sGC pathway or through S-nitrosothiol and n...
Mathai, Clinton Jourd'heuil, Frances L Lopez-Soler, Reynold I Jourd'heuil, David
Published in
Redox biology
Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather than constrained to penta coordination, cytoglobin's heme iron may exist either as a penta or hexacoordinated arrangement when exposed to different intracellular environments. Two cysteine residues at the surface of the protein form an intramolecular disulfide ...
Weber, Daniela Kochlik, Bastian Demuth, Ilja Steinhagen-Thiessen, Elisabeth Grune, Tilman Norman, Kristina
Published in
Redox biology
Regular consumption of fruits and vegetables, which is related to high plasma levels of lipid-soluble micronutrients such as carotenoids and tocopherols, is linked to lower incidences of various age-related diseases. Differences in lipid-soluble micronutrient blood concentrations seem to be associated with age. Our retrospective analysis included m...
Fontecha-Barriuso, Miguel Martín-Sanchez, Diego Martinez-Moreno, Julio M Cardenas-Villacres, Daniela Carrasco, Susana Sanchez-Niño, Maria D Ruiz-Ortega, Marta Ortiz, Alberto Sanz, Ana B
Published in
Redox biology
Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole has a lethal effect over some cancer cells, and cell death is a key process in kidney disease. ...
Laidou, Stamatia Alanis-Lobato, Gregorio Pribyl, Jan Raskó, Tamás Tichy, Boris Mikulasek, Kamil Tsagiopoulou, Maria Oppelt, Jan Kastrinaki, Georgia Lefaki, Maria
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Published in
Redox biology
Spinocerebellar ataxia type-1 (SCA1) is caused by an abnormally expanded polyglutamine (polyQ) tract in ataxin-1. These expansions are responsible for protein misfolding and self-assembly into intranuclear inclusion bodies (IIBs) that are somehow linked to neuronal death. However, owing to lack of a suitable cellular model, the downstream consequen...
Santos, Ana Isabel Lourenço, Ana Sofia Simão, Sónia Marques da Silva, Dorinda Santos, Daniela Filipa Onofre de Carvalho, Ana Paula Pereira, Ana Catarina Izquierdo-Álvarez, Alicia Ramos, Elena Morato, Esperanza
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Published in
Redox biology
Nitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation of neural stem cells (NSC), and is essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One of the mechanisms underlying non-classical NO cell signaling is protein S-nitrosylation. This post-translational modificati...
Wang, Sen Chen, Zheng Zhu, Shoumin Lu, Heng Peng, Dunfa Soutto, Mohammed Naz, Huma Peek, Richard Jr Xu, Hao Zaika, Alexander
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Published in
Redox biology
Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of antioxidant enzyme peroxiredoxin 2 (PRDX2) in gastric tumorigenesis remains unknown. In vitro (AGS and SNU-1 cell lines) and in vivo mouse models were utilized to investigate the role of PRDX2 in response to H. pylori infection (7.13, J166 or PMSS1 str...
Wang, Yiqin Liu, Xiaohui Xie, Baoshu Yuan, Hao Zhang, Yiyue Zhu, Jun
Published in
Redox biology
Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery for efficient energy metabolism, while nowadays some researches have revealed that hypoxia can induce stem cells so as to improve embryonic development. Erythroid differentiation is the oxygen delivery method employed by ve...
Barata, Ana G Dick, Tobias P
Published in
Redox biology
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the cellular response to various stresses and its deregulation accompanies pathological conditions such as cancer and chronic inflammation. Hydrogen peroxide (H2O2) is a well-established activator of the p38 MAPK signaling pathway. However, the mechanisms o...
