Published in Redox Biology
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an electron donor. There are seven enzymes in the NOX family: NOX1-5 and dual oxidase (DUOX) 1–2. NOX enzymes in humans play important roles in diverse biological functions and vary in...
Published in Redox Biology
To determine the roles of nuclear localization of pro-caspase-1 in human aortic endothelial cells (HAECs) activated by proatherogenic lipid lysophosphatidylcholine (LPC), we examined cytosolic and nuclear localization of pro-caspase-1, identified nuclear export signal (NES) in pro-caspase-1 and sequenced RNAs. We made the following findings: 1) LPC...
Published in Redox Biology
• HDAC inhibitor mediated EMT alters cellular iron metabolism and redox homeostasis. • Increased iron regulatory protein binding activity promotes iron accumulation in mesenchymal cells. • Altering cellular iron availability during HDAC inhibitor mediated EMT reduces cell viability. • HDAC inhibitor treatment increases cell death following ferropto...
Published in Redox Biology
The ultraviolet B radiation (UVB) causes skin inflammation, which contributes to the causality and the exacerbation of a number of cutaneous diseases. However, the mechanism of UVB-driven inflammation in the skin remains poorly understood. We show that ferroptosis, a non-apoptotic programmed cell death pathway that is promoted by an excessive phosp...
Published in Redox Biology
Parkinson's disease (PD) is a chronic neurodegenerative disorder that is characterized by motor symptoms as a result of a loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), accompanied by chronic neuroinflammation, oxidative stress, formation of α-synuclein aggregates. Celastrol, a potent anti-inflammatory and anti-oxidative ...
Published in Redox Biology
• Purine metabolism contribute to oxidative stress via xanthine oxidase activity. • P2X7 receptor activation induces NADPH oxidase activation and superoxide production. • P2Y1 triggers the expression of antioxidant enzymes reducing oxidative stress. • Free radicals reduce CD39 and CD73 functionality.
Published in Redox Biology
• Apigenin inhibits the upregulation of TS induced by 5-FU for apoptosis of CRC. • FOXM1 silencing enhances the potentiation of apoptosis by apigenin. • Suppressing TS and promoting P53 activity by apigenin reduce acquired 5-FU resistance.
Published in Redox Biology
• Three different serum biomarkers of selenium status are inversely associated with all-cause mortality following breast cancer diagnosis. • Lower serum glutathione peroxidase 3 activity is associated with more recurrences following breast cancer. • Patients in the lowest quintile regarding all three serum biomarkers have a particularly high all-ca...
Published in Redox Biology
• SIRT2 is the key in Sirtuin family involved in oxidative stress vascular injury. • SIRT2-KO/SIRT2-TG mice aggravates/relieves oxidative stress vascular injury. • Oxidative stress injury factor PARP1 is a novel physiological substrate of SIRT2. • Lysine 249 is of critical importance of PARP1 deacetylation by SIRT2. • SIRT2 promotes ubiquitination ...
Published in Redox Biology
• Insulin decreases ROS production in T1D Akita cardiomyocytes. • Insulin signaling downstream of PI3K is required for this effect. • Insulin increases the antioxidant capacity in the Akita heart. • Trx1 is upregulated by insulin in the Akita heart in vivo.
