Nogueira, Renato C Minnion, Magdalena Clark, Anna D Dyson, Alex Tanus-Santos, José E Feelisch, Martin
Published in
Redox biology
In blood, the majority of endothelial nitric oxide (NO) is scavenged by oxyhemoglobin, forming nitrate while a small part reacts with dissolved oxygen to nitrite; another fraction may bind to deoxyhemoglobin to generate nitrosylhemoglobin (HbNO) and/or react with a free cysteine to form a nitrosothiol. Circulating nitrite concentrations in healthy ...
Pimkova, K Jassinskaja, M Munita, R Ciesla, M Guzzi, N Cao Thi Ngoc, P Vajrychova, M Johansson, E Bellodi, C Hansson, J
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Published in
Redox biology
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behavior in normal and malignant hematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approach to comprehensively describe reversible cysteine m...
Liu, Wei Zhao, Yuechao Wang, Guangfu Feng, Shuang Ge, Xuhui Ye, Wu Wang, Zhuanghui Zhu, Yufeng Cai, Weihua Bai, Jianling
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Published in
Redox biology
Osteosarcoma (OS) is a malignant bone tumor that mainly occurs in adolescents. It is accompanied by a high rate of lung metastasis, and high mortality. Recent studies have suggested the important roles of tripartite motif-containing (TRIM) family proteins in regulating various substrates and signaling pathways in different tumors. However, the deta...
Liu, Mengru Zhou, Xinyu Li, Yue Ma, Shijia Pan, Ling Zhang, Xingxian Zheng, Wanqing Wu, Zhanxun Wang, Ke Ahsan, Anil
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Published in
Redox biology
TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress and protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP). However, the brain alters glucose metabolism from PPP to glycolysis during prolonged ischemia. It is still unknown whether and how TIGAR exerts the...
Wu, Xuan Luo, Yuhong Wang, Shan Li, Yueying Bao, Meiyu Shang, Yuanjiang Chen, Lei Liu, Weiwei
Published in
Redox biology
A kinase anchor protein 12（AKAP12）is a scaffold protein that is critical for cell structure maintenance and signal transduction. However, the role of AKAP12 in liver injury remains unclear. Here, we attempt to explore the potential contribution of AKAP12 in liver injury and elucidate its underlying molecular mechanism. We found that AKAP12 deletion...
Demircan, Kamil Sun, Qian Bengtsson, Ylva Seemann, Petra Vallon-Christersson, Johan Malmberg, Martin Saal, Lao H Rydén, Lisa Minich, Waldemar B Borg, Åke
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Published in
Redox biology
Low concentrations of serum selenium (Se) and its main transporter selenoprotein P (SELENOP) are associated with a poor prognosis following breast cancer diagnosis. Recently, natural autoantibodies (aAb) with antagonistic properties to SELENOP uptake have been identified in healthy subjects, and in patients with thyroid disease. Given the potential...
Sun, Yue Yang, Yan-Ming Hu, Yu-Yu Ouyang, Lan Sun, Zheng-Hua Yin, Xing-Feng Li, Nan He, Qing-Yu Wang, Yang
Published in
Redox biology
Sirtuin-1 (SIRT1) is a critical nuclear deacetylase that participates in a wide range of biological processes. We hereby employed quantitative acetyl-proteomics to globally reveal the landscape of SIRT1-dependent acetylation in colorectal cancer (CRC) cells stimulated by specific SIRT1 inhibitor Inauhzin (INZ). We strikingly observed that SIRT1 inh...
Fan, Hui He, Yujia Xiang, Junqi Zhou, Jing Wan, Xinyan You, Jiawei Du, Kailong Li, Yue Cui, Lin Wang, Yitao
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Published in
Redox biology
Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified to be a promising anti-cancer candidate. However, the detailed mechanisms related to its anti-cancer effects remain unclea...
Powers, Scott K. Schrager, Matthew
Published in
Redox Biology
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Zhang, Ning Lu, Yifei Huang, Yong Zhang, Qing Tan, Jianglin Zhang, Jianxiang Yao, Mengyun Luo, Gaoxing
Published in
Redox Biology
• HSNO was the preferred intermediate to study crosstalk between H2S and NO. • HSNO displayed translational potential for diagnosis and assessment of diseases. • SNP-1 displayed excellent fluorescence performance for HSNO detection. • SNP-1 could effectively image HSNO in cells and mouse models.
