Alsharif, Ifat Boukhzar, Loubna Lefranc, Benjamin Godefroy, David Aury-Landas, Juliette Rego, Jean-Luc do Rego, Jean-Claude do Naudet, Frédéric Arabo, Arnaud Chagraoui, Abdeslam
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Published in
Redox Biology
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction for which there is an unmet need for better treatment options. Although oxidative stress is a common feature of neurodegenerative diseases, notably PD, there is currently no efficient therapeutic strategy able to tackle this multi-target pathophysiological p...
Rajcic, Dragana Baumann, Anja Hernández-Arriaga, Angélica Brandt, Annette Nier, Anika Jin, Cheng Jun Sánchez, Victor Jung, Finn Camarinha-Silva, Amélia Bergheim, Ina
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Published in
Redox Biology
• l -citrulline diminished progression of non-alcoholic fatty liver disease (NAFLD). • l -citrulline protects from fructose-induced small intestinal barrier dysfunction. • NASH development is associated with a loss of arginase activity in small intestine. • l -citrulline improves intestinal arginase activity in diet-induced NAFLD. • Arginase inhibi...
Bayona-Bafaluy, M. Pilar Garrido-Pérez, Nuria Meade, Patricia Iglesias, Eldris Jiménez-Salvador, Irene Montoya, Julio Martínez-Cué, Carmen Ruiz-Pesini, Eduardo
Published in
Redox Biology
• Several chromosome 21-encoded proteins repress mitochondrial biogenesis. • These proteins are overexpressed in fetal brains of Down syndrome (DS) individuals. • Oxidative phosphorylation function is essential for neurogenesis. • Upregulation of these proteins adversely impact on neurogenesis. • Prenatal therapy with drugs inhibiting these protein...
Flouda, Konstantina Gammelgaard, Bente Davies, Michael J. Hawkins, Clare L.
Published in
Redox Biology
• HOCl induces extensive smooth muscle cell death and irreversible thiol oxidation. • Addition of SCN− decreases the extent of HOCl-induced cell damage. • SeCN− has similar protective effects to SCN− towards HOCl-induced cell damage. • HOSeCN is less toxic than HOCl but more damaging than HOSCN. • SeMet modulates HOCl-induced damage but less effect...
Cheng, Xiao Shihabudeen Haider Ali, Mohamed Sham Moran, Matthew Viana, Martonio Ponte Schlichte, Sarah L. Zimmerman, Matthew C. Khalimonchuk, Oleh Feinberg, Mark W. Sun, Xinghui
Published in
Redox Biology
•LncRNA Meg3 is a top differentially expressed lncRNA in the vascular endothelium in obese mice. •Meg3 knockdown causes cellular senescence of HUVECs and of hepatic endothelium in obese mice. •Meg3 expression is elevated in human NAFLD and NASH Nlivers, and correlates with CDKN2A expression -a senescent marker. •Meg3 knockdown impairs glucose homeo...
Martinelli, Ilenia Timotin, Andrei Moreno-Corchado, Paula Marsal, Dimitri Kramar, Solomiia Loy, Halina Joffre, Carine Boal, Frederic Tronchere, Helene Kunduzova, Oksana
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Published in
Redox Biology
• Galanin dictates autophagic phenotype in cardiomyoblasts. • Galanin suppresses myocardial apoptosis and mitochondrial oxidative stress in hypertrophic remodeling. • Galanin promotes metabolic shift from fatty acid to glucose oxidation in the hypertrophied hearts. • Galanin regulates cardiac autophagy and apoptosis through FoxO1 pathway.
Ma, Juan Qian, Christopher Bao, Yong Liu, Meng-Yue Ma, Hui-Min Shen, Meng-Qi Li, Wei Wang, Jiao-Jiao Bao, Yu-Xin Liu, Yong
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Published in
Redox Biology
• Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice. • ApoE−/− induced a progressive accumulation of iron with age in the liver and spleen of mice. • The increased iron was due to upregulation of TfR1 and downregulation of Fpn1. • Replenishment of ApoE could partially reverse the iron-related phenot...
Dobani, Sara Latimer, Cheryl McDougall, Gordon J. Allwood, J. William Pereira-Caro, Gema Moreno-Rojas, José Manuel Ternan, Nigel G. Pourshahidi, L. Kirsty Lawther, Roger Tuohy, Kieran M.
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Published in
Redox Biology
• Health effects of dietary (poly)phenols linked to interactions within the GI tract. • Ileostomy-based bioavailability studies allow effective interrogation of the GI tract. • Fecal fermentation of raspberry-enriched ileal fluid, increases phenolic content. • Raspberry ileal fluid fermentates & phenolic acids reduce DNA damage in colonocytes. • Cy...
Kwak, Man Sup Rhee, Woo Joong Lee, Yong Joon Kim, Hee Sue Kim, Young Hun Kwon, Min Kyung Shin, Jeon-Soo
Published in
Redox biology
Oxidative stress can induce covalent disulfide bond formation between protein-protein thiol groups and generate hydroxyl free radicals that damage DNA. HMGB1 is a DNA chaperone and damage-associated molecular pattern molecule. As a redox-sensitive protein, HMGB1 contains three cysteine residues: Cys23, Cys45, and Cys106. In this study, we focused o...
Pagano, Giovanni Tiano, Luca Pallardó, Federico V Lyakhovich, Alex Mukhopadhyay, Sudit S Di Bartolomeo, Paolo Zatterale, Adriana Trifuoggi, Marco
Published in
Redox biology
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients' cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. A...
