Mallet, Romain Modzelewski, Romain Lequesne, Justine Mihailescu, Sorina Decazes, Pierre Auvray, Hugues Benyoucef, Ahmed Di Fiore, Fréderic Vera, Pierre Dubray, Bernard
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Published in
Radiation Oncology
BackgroundSarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including patients undergoing surgery for limited oesophageal cancer. Concomitant chemo-radiotherapy is the standard treatment for locally-advanc...
Spinelli, Antonello E. Bresolin, Andrea Zuppone, Stefania Perani, Laura Fallara, Giuseppe Di Muzio, Nadia Vago, Riccardo Fiorino, Claudio Cozzarini, Cesare
Published in
Radiation Oncology
BackgroundMethods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim seems promising, but is still relatively unexplored. A method using ultrasound for bladder wall thickness quantification in rats was ...
Chang, Yu Xiao, Feng Quan, Hong Yang, Zhiyong
Published in
Radiation Oncology
PurposeMargins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Here, we proposed a margin concept that takes into consideration the beam direction, thereby generating a beam-specific planning target volume (BSPTV) on a beam entrance view. The total m...
Byun, David J. Gorovets, Daniel J. Jacobs, Lauren M. Happersett, Laura Zhang, Pengpeng Pei, Xin Burleson, Sarah Zhang, Zhigang Hunt, Margie McBride, Sean
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Published in
Radiation Oncology
BackgroundTo evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences.MethodsEighty-five patients with 510 computed tomography (CT) images were analyzed. Median prescription dose was 40 Gy in 5 fractions. Patients were instructed to maint...
Jin, Qing Lin, Cunzhi Zhu, Xinhong Cao, Yiwei Guo, Caihong Wang, Lijun
Published in
Radiation Oncology
BackgroundLung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 seed (125I) irradiation can be used as an important adjuvant treatment for lung carcinoma. The purpose of this study was to examine ...
Thiyagarajan, Rajesh Sharma, Dayananda Shamurailatpam Kaushik, Suryakant Sawant, Mayur Ganapathy, K. Nambi Raj, N. Arunai Chilukuri, Srinivas Sundar, Sham C. Patro, Kartikeswar Ch. Manikandan, Arjunan
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Published in
Radiation Oncology
There is no ideal detector-phantom combination to perform patient specific quality assurance (PSQA) for Total Marrow (TMI) and Lymphoid (TMLI) Irradiation plan. In this study, 3D dose reconstruction using mega voltage computed tomography detectors measured Leaf Open Time Sinogram (LOTS) was investigated for PSQA of TMI/TMLI patients in helical tomo...
Yang, Yongqiang Ma, Yifu Xiang, Xiaoyong Xing, Pengfei Wu, Yongyou Zhang, Liyuan Tian, Ye
Published in
Radiation Oncology
BackgroundNearly 50% of new gastric cancer cases and gastric cancer-related deaths worldwide occur in China. No global consensus has been reached about the optimal management of locally advanced gastric cancer. Although the Guidelines for the Diagnosis and Treatment of Gastric Cancer from the National Health Commission of China, which has been upda...
Krug, David Köder, Christine Häfner, Matthias F. Arians, Nathalie Harrabi, Semi B. Koerber, Stefan A. Forster, Tobias Schlampp, Ingmar Sohn, Christof Heil, Joerg
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Published in
Radiation Oncology
BackgroundIntensity-modulated radiotherapy (IMRT) improves dose homogeneity and late toxicity compared to simple tangential techniques in adjuvant whole-breast radiotherapy for patients with breast cancer. Simultaneous-integrated boost (SIB) radiotherapy shortens the overall treatment time and improves dose homogeneity. However, prospective randomi...
Kim, Yeon Joo Ahn, Hanjong Kim, Choung-Soo Kim, Young Seok
Published in
Radiation Oncology
BackgroundTo evaluate the clinical outcomes of combination of androgen deprivation therapy (ADT), whole pelvic radiotherapy (WPRT), and stereotactic body radiotherapy (SBRT) boost in high-risk prostate cancer patients.MethodsThis prospective phase I/IIa study was conducted between 2016 and 2017. Following WPRT of 44 Gy in 20 fractions, patients wer...
Shamseddine, Ali Zeidan, Youssef H. El Husseini, Ziad Kreidieh, Malek Al Darazi, Monita Turfa, Rim Kattan, Joseph Khalifeh, Ibrahim Mukherji, Deborah Temraz, Sally
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Published in
Radiation Oncology
BackgroundNeoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death-Ligand 1 (PD-L1) and prevents the suppression of the cytotoxic T cell immune response. This phase II trial evaluates the safety an...
