Wu, Vincent W. C. Tam, Shing-yau
Published in
Radiation Oncology
Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of the temporal lobes is inevitable despite the use of the more advanced intensity-modulated radiotherapy (IMRT). Moreover, the diagnosis and trea...
Samaga, Daniel Hornung, Roman Braselmann, Herbert Hess, Julia Zitzelsberger, Horst Belka, Claus Boulesteix, Anne-Laure Unger, Kristian
Published in
Radiation Oncology
BackgroundPrognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model development process requires two independent discovery and validation data sets. Each of them may contain samples collected in a sing...
Geinitz, Hans Nieder, Carsten Kocik, Lukas Track, Christine Feichtinger, Johann Weingartner, Theresa Spiegl, Kurt Füreder-Kitzmüller, Barbara Kaufmann, Johanna Seewald, Dietmar H.
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Published in
Radiation Oncology
PurposeTo report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.Patients and Methods: This was a retrospective single institution study with median follow-up of 101 months (8.4 years). Patients who were alive at the time of analysis in 2018 were conta...
Sarria, Gustavo R. Petrova, Vera Wenz, Frederik Abo-Madyan, Yasser Sperk, Elena Giordano, Frank A.
Published in
Radiation Oncology
BackgroundSoft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-energy photons is herein presented.MethodsThirty-one patients with newly and recurrent STS were retrospectively assessed. EIORT was a...
Kowalchuk, Roman O. Waters, Michael R. Richardson, K. Martin Spencer, Kelly Larner, James M. Irvin, William P. Kersh, Charles R.
Published in
Radiation Oncology
BackgroundThis study evaluates the outcomes and toxicity of stereotactic body radiation therapy (SBRT) in ovarian cancer.MethodsThis retrospective analysis considered all patients treated with SBRT from 2009 to 2018 with a primary ovarian tumor. Follow-up included PET-CT and CT scans at 2–3 month intervals. Statistical analysis primarily consisted ...
Wang, Dan Liu, Chongshun Zhou, Yuan Yan, Tingyu Li, Chenglong Yang, Qionghui Xu, Yang Zhao, Lilan Pei, Qian Tan, Fengbo
...
Published in
Radiation Oncology
BackgroundNeoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with non-metastatic PDAC remains controversial. Therefore, the purpose of this study was to analyze the benefits of only surgery, neoadj...
Kim, Nalee Chang, Jee Suk Kim, Yong Bae Kim, Jin Sung
Published in
Radiation Oncology
BackgroundSince intensity-modulated radiation therapy (IMRT) has become popular for the treatment of gynecologic cancers, the contouring process has become more critical. This study evaluated the feasibility of atlas-based auto-segmentation (ABAS) for contouring in patients with endometrial and cervical cancers.MethodsA total of 75 sets of planning...
Savenije, Mark H. F. Maspero, Matteo Sikkes, Gonda G. van der Voort van Zyp, Jochem R. N. T. J. Kotte, Alexis N. Bol, Gijsbert H. T. van den Berg, Cornelis A.
Published in
Radiation Oncology
BackgroundStructure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promising results. With the advent of magnetic resonance imaging (MRI)-guided radiotherapy, MR-based segmentation is becoming increasingl...
Afkham, Younes Mesbahi, Asghar Alemi, Abdolali Zolfagharpour, Farhad Jabbari, Nasrollah
Published in
Radiation Oncology
BackgroundPhoto-neutrons are produced at the head of the medical linear accelerators (linac) by the interaction of high-energy photons, and patients receive a whole-body-absorbed dose from these neutrons. The current study aimed to find an efficient shielding material for fast neutrons.MethodsNanoparticles (NPs) of Fe3O4 and B4C were applied in a m...
Liao, Xiongfei Wu, Fan Wu, Junxiang Peng, Qian Yao, Xinghong Kang, Shengwei Zhao, Yanqun Orlandini, Lucia Clara
Published in
Radiation Oncology
BackgroundVolumetric modulated arc therapy (VMAT) adopted in post-mastectomy radiation therapy (PMRT) has the capacity to achieve highly conformal dose distributions. The research aims to evaluate the impact of positioning errors in the dosimetry of VMAT left-sided PMRT.MethodsA total of 18 perturbations where introduced in 11 VMAT treatment plans ...
