Mein, Stewart Kopp, Benedikt Vela, Anthony Dutheil, Pauline Lesueur, Paul Stefan, Dinu Debus, Jürgen Haberer, Thomas Abdollahi, Amir Mairani, Andrea
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Published in
Radiation Oncology
BackgroundTo develop an auxiliary GPU-accelerated proton therapy (PT) dose and LETd engine for the IBA Proteus®ONE PT system. A pediatric low-grade glioma case study is reported using FRoG during clinical practice, highlighting potential treatment planning insights using variable RBE dose (DvRBE) and LETd as indicators for clinical decision making ...
Mäurer, Matthias Käsmann, Lukas Fleischmann, Daniel F. Oertel, Michael Jazmati, Danny Medenwald, Daniel
Published in
Radiation Oncology
BackgroundStage III non-small cell lung cancer (NSCLC) represents a highly heterogeneous disease and treatment burden. Advances in imaging modality show promising results for radiotherapy planning. In this multicentric study, we evaluated the impact of PET/CT-based radiotherapy planning on the prognosis of patients with stage III NSCLC.Method and p...
Kim, Tae Gyu Park, Byungdo Song, Yun Gyu Lee, Hyoun Wook Oh, Tae Hee Ryu, Dong-Soo Jeong, Seung Chan Cho, Daehyeon Oh, Jieun Kim, Kwang Min
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Published in
Radiation Oncology
BackgroundSeveral studies have reported patient-related risk factors for late rectal bleeding following conventionally fractionated radiotherapy for prostate cancer. We investigated patient-related risk factors for late rectal bleeding after hypofractionated radiotherapy.MethodsA total of 231 patients with local or locally advanced prostate cancer ...
Asbach, John C. Singh, Anurag K. Matott, L. Shawn Le, Anh H.
Published in
Radiation Oncology
BackgroundWith the rapid growth of deep learning research for medical applications comes the need for clinical personnel to be comfortable and familiar with these techniques. Taking a proven approach, we developed a straightforward open-source framework for producing automatic contours for head and neck planning computed tomography studies using a ...
Grocutt, Laura Paterson, Claire Valentine, Ronan M.
Published in
Radiation Oncology
BackgroundA significant proportion of patients with poor prognosis squamous cell cancer of the oropharynx relapse loco-regionally despite radical (chemo)radiotherapy. If a predictive biomarker for disease control can be identified during treatment then individualised and adaptive treatment strategies may be employed. The aim of this study is to ass...
Lim, Yu Jin Song, Changhoon Kim, Hak Jae
Published in
Radiation Oncology
BackgroundIn the modern era of magnetic resonance imaging (MRI) staging, the benefit of prophylactic cranial irradiation (PCI) in patients with small-cell lung cancer (SCLC) has been controversial. This study evaluated the prognostic impact of PCI in patients with limited- or extensive-stage SCLC who had no brain metastases at diagnosis according t...
Kneepkens, Esther Bakx, Nienke van der Sangen, Maurice Theuws, Jacqueline van der Toorn, Peter-Paul Rijkaart, Dorien van der Leer, Jorien van Nunen, Thérèse Hagelaar, Els Bluemink, Hanneke
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Published in
Radiation Oncology
BackgroundArtificial intelligence (AI) shows great potential to streamline the treatment planning process. However, its clinical adoption is slow due to the limited number of clinical evaluation studies and because often, the translation of the predicted dose distribution to a deliverable plan is lacking. This study evaluates two different, deliver...
Borm, Kai J. Ernst, Lucia Voppichler, Julia Oechsner, Markus Düsberg, Mathias Buschner, Gabriel Weber, Wolfgang Combs, Stephanie E. Duma, Marciana N.
Published in
Radiation Oncology
BackgroundCurrent literature lacks a comparison of lymph node metastases and non-pathological lymph nodes distribution in breast cancer patients. The aim of the current retrospective study was to generate a comprehensive atlas of the lymph node system.Methods143 breast cancer patients underwent F-18-FDG-PET/CT (PET/CT) imaging for staging purposes ...
Shi, Jinming Tang, Yuan Li, Ning Song, Yongwen Wang, Shulian Liu, Yueping Fang, Hui Lu, Ningning Tang, Yu Qi, Shunan
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Published in
Radiation Oncology
BackgroundRespiratory motion may introduce errors during radiotherapy. This study aims to assess and validate internal gross tumour volume (IGTV) margins in proximal and distal borders of gastroesophageal junction (GEJ) tumours during simultaneous integrated boost radiotherapy.MethodsWe enrolled 10 patients in group A and 9 patients in group B. For...
Kawula, Maria Purice, Dinu Li, Minglun Vivar, Gerome Ahmadi, Seyed-Ahmad Parodi, Katia Belka, Claus Landry, Guillaume Kurz, Christopher
Published in
Radiation Oncology
BackgroundThe evaluation of automatic segmentation algorithms is commonly performed using geometric metrics. An analysis based on dosimetric parameters might be more relevant in clinical practice but is often lacking in the literature. The aim of this study was to investigate the impact of state-of-the-art 3D U-Net-generated organ delineations on d...
