Zanella, Camila A Tasca, Carla I Henley, Jeremy M Wilkinson, Kevin A Cimarosti, Helena I
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Purinergic signalling
SUMOylation is a post-translational modification (PTM) whereby members of the Small Ubiquitin-like MOdifier (SUMO) family of proteins are conjugated to lysine residues in target proteins. SUMOylation has been implicated in a wide range of physiological and pathological processes, and much attention has been given to its role in neurodegenerative co...
Cardoso, Andréia Machado
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Purinergic Signalling
Wang, Haiwei Wang, Xinrui Xu, Liangpu Zhang, Ji Cao, Hua
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Purinergic Signalling
Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear. Using the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, we found that the pyrimidine met...
Zou, Lifang Tu, Guihua Xie, Wei Wen, Shiyao Xie, Qiuyu Liu, Shuangmei Li, Guilin Gao, Yun Xu, Hong Wang, Shouyu
...
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Purinergic Signalling
Ren, Yulan Chen, Zhihan Wang, Rui Yu, Yang Li, Dehua He, Yonggang
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Purinergic signalling
Electroacupuncture (EA) can improve myocardial ischemia (MI) injury; nevertheless, the mechanism is not entirely clear. And there were disagreements about whether the effect of EA at acupoint in disease-affected meridian is better than EA at acupoint in non-affected meridian and sham acupoint. Here, we showed that the effect of EA at Neiguan (PC6) ...
He, Jin-Rong Yu, Shu-Guang Tang, Yong Illes, Peter
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Purinergic Signalling
This review summarizes experimental evidence indicating that purinergic mechanisms are causally involved in acupuncture (AP)-induced analgesia. Electroacupuncture (EAP) and manual AP release at pain-relevant acupoints ATP which may activate purinergic P2X receptors (Rs) especially of the P2X3 type situated at local sensory nerve endings (peripheral...
Cymer, Monika Brzezniakiewicz-Janus, Katarzyna Bujko, Kamila Thapa, Arjun Ratajczak, Janina Anusz, Krzysztof Tracz, Michał Jackowska-Tracz, Agnieszka Ratajczak, Mariusz Z. Adamiak, Mateusz
...
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Purinergic Signalling
An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological mobilization from the bone marrow (BM) into peripheral blood (PB) and subsequent proper homing and engraftment of these cells are crucial for clinical outcomes from hematopoietic transplants. Since extracellular adenosine triphosphate (eATP) plays an important...
Abbracchio, Maria P. Jacobson, Kenneth A. Müller, Christa E. Zimmermann, Herbert
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Purinergic Signalling
Rodrigues, A M Serralha, R S Lima, D Y Punaro, G R Visona, I Fernandes, M J S Higa, E M S
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Purinergic signalling
Previous studies in our laboratory have suggested that P2X7 could contribute to the progression of diabetic nephropathy and modulated klotho expression. The aim of this study was to investigate if P2X7 receptor is related to the expression of klotho in the onset of diabetic nephropathy in rats. Seven-week-old male Wistar rats weighing 210 g were al...
de Souza Nicoletti, Aline Passos, Gabriela Reolon Bertollotto, Gabriela Maria Lescano, Caroline Honaiser de Oliveira, Mariana Gonçalves Antunes, Edson Mónica, Fabiola Zakia
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Purinergic Signalling
In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is terminated by phosphodiesterases and efflux transporters, which pump cGMP out of the cell. The nucleotides, GTP, and cGMP were detected in the extracellular space, and their hydrolysis lead to the...