Gorka, Adam X Lago, Tiffany R Balderston, Nicholas Torrisi, Salvatore Fuchs, Bari Grillon, Christian Ernst, Monique
Published in
Psychopharmacology
The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive processing and reduce connectivity between th...
Newman, Mark Ferrario, Carrie R.
Published in
Psychopharmacology
The incorporation of microeconomics concepts into studies using self-administration procedures has provided critical insights into the factors that influence consumption of a wide range of food and drug reinforcers. In particular, the fitting of demand curves to consumption data provides a powerful analytic tool for computing objective metrics of b...
Di Lemma, Lisa C. G. Stancak, Andrej Soto, Vicente Fallon, Nick Field, Matt
Published in
Psychopharmacology
Rationale Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. Objectives The present study investigated the effects of a single session of CAT on event-related and readiness potentials during preparation of approach and avoid...
Verharen, Jeroen P. H. den Ouden, Hanneke E. M. Adan, Roger A. H. Vanderschuren, Louk J. M. J.
Published in
Psychopharmacology
Rationale During value-based decision-making, organisms make choices on the basis of reward expectations, which have been formed during prior action-outcome learning. Although it is known that neuronal manipulations of different subregions of the rat prefrontal cortex (PFC) have qualitatively different effects on behavioral tasks involving value-ba...
Messanvi, F Perkins, A du Hoffmann, J Chudasama, Y
Published in
Psychopharmacology
The neuropeptide galanin has been implicated in a wide range of pathological conditions in which frontal and temporal structures are compromised. It works through three subtypes of G-protein-coupled receptors. One of these, the galanin receptor 1 (Gal-R1) subtype, is densely expressed in the ventral hippocampus (vHC) and ventral prefrontal cortex (...
Both, S. Van Veen, R. J. B. Brom, M. Weijenborg, P. T. M.
Published in
Psychopharmacology
Rationale and objective The aim of this study was to investigate the possible facilitating effect of the partial NMDA receptor agonist D-cycloserine (DCS) on memory consolidation of conditioned sexual responses and to examine the capability of DCS to reduce context-specificity of learning. Methods In a randomized placebo-controlled double-blind tri...
González, Débora Cantillo, Jordi Pérez, Irene Farré, Magí Feilding, Amanda Obiols, Jordi E. Bouso, José Carlos
Published in
Psychopharmacology
Rationale Recent studies have assessed the therapeutic potential of ayahuasca for the treatment of depression with promising preliminary results . Objectives Here, we examine the course of grief over 1 year of follow-up in a bereaved sample that attended a center in Peru to participate in indigenous Shipibo ayahuasca ceremonies. We also explore the...
Appiah-Kusi, E. Petros, N. Wilson, R. Colizzi, M. Bossong, M. G. Valmaggia, L. Mondelli, V. McGuire, P. Bhattacharyya, S.
Published in
Psychopharmacology
Rationale Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic and anxiolytic effects. Objectives We investigated whether CBD would normalise the neuroendocrine and anxiety responses to stress in clinical high risk for psychosis (CHR) patients. Methods Thirty-two CHR...
Ellis, Alexandra S. Toussaint, Andre B. Knouse, Melissa Thomas, Arthur S. Bongiovanni, Angela R. Mayberry, Hannah L. Bhakta, Shivam Peer, Kyle Bangasser, Debra A. Wimmer, Mathieu E.
...
Published in
Psychopharmacology
Rationale: Parental drug use around or before conception can have adverse consequences for offspring. Historically, this research has focused on the effects of maternal substance use on future generations but less is known about the influence of the paternal lineage. This study focused on the impact of chronic paternal morphine exposure prior to co...
Vinckenbosch, F. R. J. Vermeeren, A. Verster, J. C. Ramaekers, J. G. Vuurman, E. F.
Published in
Psychopharmacology
Background Standard deviation of lateral position (SDLP) has been accepted as a reliable parameter for measuring driving impairment due to lowered vigilance caused by sleepiness or the use of sedating drugs. Recently, lane drifts were proposed as an additional outcome measure quantifying momentary lapses of attention. The purpose of this study was ...
