Ahn-Horst, Rosa Y Turner, Erick H
Published in
Psychological medicine
To test for publication bias with alprazolam, the most widely prescribed benzodiazepine, by comparing its efficacy for panic disorder using trial results from (1) the published literature and (2) the US Food and Drug Administration (FDA). From FDA reviews, we included data from all phase 2/3 efficacy trials of alprazolam extended-release (Xanax XR)...
Buchwald, Khan Narayanan, Ajit Siegert, Richard John Vignes, Matthieu Arrowsmith, Kim Sandham, Margaret
Published in
Psychological medicine
The network theory of psychological disorders posits that systems of symptoms cause, or are associated with, the expression of other symptoms. Substantial literature on symptom networks has been published to date, although no systematic review has been conducted exclusively on symptom networks of schizophrenia, schizoaffective disorder, and schizop...
Davies, Cathy Bossong, Matthijs G Martins, Daniel Wilson, Robin Appiah-Kusi, Elizabeth Blest-Hopley, Grace Zelaya, Fernando Allen, Paul Brammer, Michael Perez, Jesus
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Published in
Psychological medicine
Hippocampal hyperperfusion has been observed in people at Clinical High Risk for Psychosis (CHR), is associated with adverse longitudinal outcomes and represents a potential treatment target for novel pharmacotherapies. Whether cannabidiol (CBD) has ameliorative effects on hippocampal blood flow (rCBF) in CHR patients remains unknown. Using a doubl...
Borgers, Tiana Enneking, Verena Klug, Melissa Garbe, Jasper Meinert, Hannah Wulle, Marius König, Philine Zwiky, Esther Herrmann, Rebekka Selle, Janine
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Published in
Psychological medicine
Magnetic resonance imaging (MRI) studies on major depressive disorder (MDD) have predominantly found short-term electroconvulsive therapy (ECT)-related gray matter volume (GMV) increases, but research on the long-term stability of such changes is missing. Our aim was to investigate long-term GMV changes over a 2-year period after ECT administration...
Goh, Kah Kheng Kanahara, Nobuhisa Chiu, Yi-Hang Lu, Mong-Liang
Published in
Psychological medicine
Childhood trauma has been linked to increased risk of schizophrenia and social dysfunction, and oxytocin and its receptor gene have been implicated in regulating social behavior. This study investigated the potential role of oxytocin and oxytocin receptor gene (OXTR) in mediating the effects of childhood trauma on social functioning in schizophreni...
Varese, Filippo Sellwood, William Pulford, Daniel Awenat, Yvonne Bird, Leanne Bhutani, Gita Carter, Lesley-Anne Davies, Linda Aseem, Saadia Davis, Claire
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Published in
Psychological medicine
Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale randomized controlled trial (RCT) of an Eye Movement...
Qiu, Xinye Robert, Andrea L McAlaine, Kaleigh Quan, Luwei Mangano, Joseph Weisskopf, Marc G
Published in
Psychological medicine
Early-life stressful experiences are associated with increased risk of adverse psychological outcomes in later life. However, much less is known about associations between early-life positive experiences, such as participation in cognitively stimulating activities, and late-life mental health. We investigated whether greater engagement in cognitive...
Veeneman, R R Vermeulen, J M Bialas, M Bhamidipati, A K Abdellaoui, A Munafò, M R Denys, D Bezzina, C R Verweij, K J H Tadros, R
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Published in
Psychological medicine
Individuals with serious mental illness have a markedly shorter life expectancy. A major contributor to premature death is cardiovascular disease (CVD). We investigated associations of (genetic liability for) depressive disorder, bipolar disorder and schizophrenia with a range of CVD traits and examined to what degree these were driven by important...
Hotte-Meunier, Adèle Penney, Danielle Mendelson, Daniel Thibaudeau, Élisabeth Moritz, Steffen Lepage, Martin Sauvé, Geneviève
Published in
Psychological medicine
Individuals with schizophrenia spectrum and related psychotic disorders (SSD) experience significant impairments in social cognition that impede functioning. Social cognition is a multidimensional construct consisting of four domains: 1. theory of mind, 2. emotion processing, 3. attributional style and 4. social perception. Metacognitive training (...
Geulayov, G Casey, D Bale, L Brand, F Clements, C Kapur, N Ness, J Waters, K White, S Hawton, K
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Published in
Psychological medicine
We investigated disparities in the clinical management of self-harm following hospital presentation with self-harm according to level of socio-economic deprivation (SED) in England. 108 092 presentations to hospitals (by 57 306 individuals) after self-harm in the Multicenter Study of Self-harm spanning 17 years. Area-level SED was based on the Engl...
