Ahmed, Dyari H Fateh, Hawal Lateef
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Prostaglandins & other lipid mediators
Since the effects of flaxseed supplementation on lipid profile and liver enzymes are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of flaxseed supplementation on lipid profile and liver enzymes. The study was designed, conducted, and reported according to the guidelines ...
Chistyakov, Dmitry V Azbukina, Nadezhda V Lopachev, Alexander V Goriainov, Sergei V Astakhova, Alina A Ptitsyna, Elena V Klimenko, Anna S Poleshuk, Vsevolod V Kazanskaya, Rogneda B Fedorova, Tatiana N
...
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Prostaglandins & other lipid mediators
Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipi...
Moustafa, Mohamed Khalil, Abraham Darwish, Noureldien H E Zhang, Dao-Qi Tawfik, Amany Al-Shabrawey, Mohamed
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Prostaglandins & other lipid mediators
Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate network of cellular and molecular mechanisms. This study sought to explore the mechanisms by investigating the role of 12-hydroxyeicosatetraenoic acid (12-HETE), its receptor GPR31, and microRNA (miR-29) in the context of DR, specifically focusing on their...
de Oliveira, Jhony Robson Pereira, Aline Beatriz Mahler de Souza, Henrique Ismarsi Dos Santos, Wanessa Maria de Assunção, Thaís Sorares Farnesi de Vito, Fernanda Bernadelli de Souza, Helio Moraes da Silva, Paulo Roberto da Silva, Marcos Vinicius Junior, Virmondes Rodrigues
...
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Prostaglandins & other lipid mediators
Smoking causes several diseases such as chronic obstructive pulmonary disease (COPD). Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and demonstrates anti-inflammatory and pro-resolution effects in several inflammatory experimental models including in the airways. Here we evaluated the rol...
Koyuncu, Açelya Gül Cumbul, Alev Akyüz, Elvan Yilmaz Noval, Muge Kopuz Alvarez
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Prostaglandins & other lipid mediators
Pomegranate seed oil, extracted from pomegranate seeds, is a slightly fragrant yellow oil with a mild odor. Pomegranate seed oil is the main source of punicic acid (conjugated linolenic acid). Punicic acid is a long-chain omega-5 polyunsaturated fatty acid and a conjugated α-linolenic acid molecule. This acid is thought to provide many health benef...
Espinoza, Keila S Hermanson, Kyra N Beard, Cameron A Schwartz, Nicholas U Snider, Justin M Low, Benjamin E Wiles, Michael V Hannun, Yusuf A Obeid, Lina M Snider, Ashley J
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Prostaglandins & other lipid mediators
Charcot-Marie-Tooth Disease (CMT) is a commonly inherited peripheral polyneuropathy. Clinical manifestations for this disease include symmetrical distal polyneuropathy, altered deep tendon reflexes, distal sensory loss, foot deformities, and gait abnormalities. Genetic mutations in heat shock proteins have been linked to CMT2. Specifically, mutatio...
Birkic, Nada Visentin, David Svedružić, Željko Reynolds, Christian A
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Prostaglandins & other lipid mediators
The transient receptor potential vanilloid 1 (TRPV1) channel is a ligand-gated, nonselective cation channel expressed in primary sensory neurons, which has a role in nociception. The channel is activated by noxious heat, pH, capsaicin and other endogenous vanilloids, including lipid mediators (LMs) enzymatically derived from polyunsaturated fatty a...
Ben-Mustapha, Yamina Ben-Fradj, Mohamed Kacem Hadj-Taieb, Sameh Serghini, Meriem Ben Ahmed, Melika Boubaker, Jalel Feki, Moncef
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Prostaglandins & other lipid mediators
Selected mucosal and plasma polyunsaturated fatty acids (PUFAs) and related oxylipins and endocannabinoids were determined in 28 Crohn's disease (CD) patients and 39 controls. Fasting blood and colonic biopsies were collected in all participants, during a disease flare for the patients. Thirty-two lipid mediators including PUFAs, oxylipins, and end...
Paquot, Adrien Bestard-Escalas, Juan Muccioli, Giulio G
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Prostaglandins & other lipid mediators
Arachidonic acid-derived prostaglandins are widely studied for their role in inflammation. However, besides arachidonic acid, other arachidonic moiety-containing lipids can be metabolized by COX-2. Indeed, the endocannabinoids 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide, AEA) can follow the same biochemical pathways tha...
Dere Yelken, H Elci, M P Turker, P F Demirkaya, S
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Prostaglandins & other lipid mediators
The study investigated the effect of different omega (ω)- 3 and omega (ω)- 6 polyunsaturated fatty acid (PUFA) ratios on cytokine secretion, cell viability, and microglial cell shape in lipopolysaccharide (LPS)-induced microglia. The addition of PUFAs at different ratios, especially ω-3 and ratios of 7/1 and 2/1 ω-6/ω-3, resulted in a significant i...
