Dua, Harminder S Freitas, Rui Mohammed, Imran Ting, Darren S J Said, Dalia G
Published in
Progress in retinal and eye research
The pre-Descemet's layer/Dua's layer, also termed the Dua-Fine layer and the pre-posterior limiting lamina layer, lies anterior to the Descemet's membrane in the cornea, is 10 μm (range 6-16) thick, made predominantly of type I and some type VI collagen with abundant elastin, more than any other layer of the cornea. It has high tensile strength (bu...
Govers, Birgit M van Huet, Ramon A C Roosing, Susanne Keijser, Sander Los, Leonoor I den Hollander, Anneke I Klevering, B Jeroen
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Progress in retinal and eye research
Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants immediate surgical intervention. To date, 29 genes have been associated with monogenic disorders involving RRD. In addition, RRD can occur as a multifactorial disease through a combined effect of multiple genetic variants and non-genetic risk factors. In this rev...
Pan, Yang Fu, Yingbin Baird, Paul N Guymer, Robyn H Das, Taraprasad Iwata, Takeshi
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Progress in retinal and eye research
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) have shown that the region at chromosome 10q26, where the age-related maculopathy susceptibility (ARMS2/LOC387715) and HtrA serine peptidase 1 (HTRA1) genes are located, rep...
Schmetterer, Leopold Scholl, Hendrik Garhöfer, Gerhard Janeschitz-Kriegl, Lucas Corvi, Federico Sadda, SriniVas R Medeiros, Felipe A
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Progress in retinal and eye research
With the identification of novel targets, the number of interventional clinical trials in ophthalmology has increased. Visual acuity has for a long time been considered the gold standard endpoint for clinical trials, but in the recent years it became evident that other endpoints are required for many indications including geographic atrophy and inh...
Merle, David A Sen, Merve Armento, Angela Stanton, Chloe M Thee, Eric F Meester-Smoor, Magda A Kaiser, Markus Clark, Simon J Klaver, Caroline C W Keane, Pearse A
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Progress in retinal and eye research
Despite comprehensive research efforts over the last decades, the pathomechanisms of age-related macular degeneration (AMD) remain far from being understood. Large-scale genome wide association studies (GWAS) were able to provide a defined set of genetic aberrations which contribute to disease risk, with the strongest contributors mapping to distin...
Jonas, Jost B Jonas, Rahul A Bikbov, Mukharram M Wang, Ya Xing Panda-Jonas, Songhomitra
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Progress in retinal and eye research
Myopic axial elongation is associated with various non-pathological changes. These include a decrease in photoreceptor cell and retinal pigment epithelium (RPE) cell density and retinal layer thickness, mainly in the retro-equatorial to equatorial regions; choroidal and scleral thinning pronounced at the posterior pole and least marked at the ora s...
Clahsen, Thomas Hadrian, Karina Notara, Maria Schlereth, Simona L Howaldt, Antonia Prokosch, Verena Volatier, Thomas Hos, Deniz Schroedl, Falk Kaser-Eichberger, Alexandra
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Progress in retinal and eye research
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent years, however, it became evident, that lymphatic vessels or lymphatic-like vessels contribute to several ocular pathologies at various peri- and intraocular locations. The aim of this review is to outline the pathogenetic role of ocular lymphatics, the respe...
Wood, Edward H Kreymerman, Alexander Kowal, Tia Buickians, David Sun, Yang Muscat, Stephanie Mercola, Mark Moshfeghi, Darius M Goldberg, Jeffrey L
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Progress in retinal and eye research
Optogenetics is defined as the combination of genetic and optical methods to induce or inhibit well-defined events in isolated cells, tissues, or animals. While optogenetics within ophthalmology has been primarily applied towards treating inherited retinal disease, there are a myriad of other applications that hold great promise for a variety of ey...
Ju, Won-Kyu Perkins, Guy A Kim, Keun-Young Bastola, Tonking Choi, Woo-Young Choi, Soo-Ho
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Progress in retinal and eye research
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their axons, resulting in vision loss. Despite its high prevalence in individuals 60 years of age and older, the causing factors contributing to glaucoma progression are cu...
Barboni, Mirella Telles Salgueiro Joachimsthaler, Anneka Roux, Michel J Nagy, Zoltán Zsolt Ventura, Dora Fix Rendon, Alvaro Kremers, Jan Vaillend, Cyrille
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Progress in retinal and eye research
Duchenne muscular dystrophy (DMD) is caused by X-linked inherited or de novo DMD gene mutations predominantly affecting males who develop early-onset muscle degeneration, severely affecting their quality of life and leading to reduced life expectancy. DMD patients may also develop proliferative retinopathy, cataract, ERG abnormalities, altered cont...
