Zhao, Weihua Luo, Ruixue Sindermann, Cornelia Li, Jialin Wei, Zhenyu Zhang, Yingying Liu, Congcong Le, Jiao Quintana, Daniel S Montag, Christian
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Progress in neuro-psychopharmacology & biological psychiatry
Intranasal oxytocin (OXT) has been associated with effects on diverse social-emotional domains in humans, however progress towards a therapeutic application of OXT in disorders with social-emotion impairments is currently hampered by poor replicability. Limited statistical power and individual differences in biological factors, such as oxytocin rec...
Fraga, Daiane B Costa, Ana Paula Olescowicz, Gislaine Camargo, Anderson Pazini, Francis L E Freitas, Andiara Moretti, Morgana S Brocardo, Patricia S Rodrigues, Ana Lúcia
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Progress in neuro-psychopharmacology & biological psychiatry
Growing evidence has suggested that ascorbic acid may exhibit rapid anxiolytic and antidepressant-like effects. In this study the effects of a single administration of ascorbic acid (1 mg/kg, p.o.), ketamine (1 mg/kg, i.p., a fast-acting antidepressant) and fluoxetine (10 mg/kg, p.o., conventional antidepressant) were investigated on: a) behavioral...
Traicu, Alexandru Grizenko, Natalie Fortier, Marie-Ève Fageera, Weam Sengupta, Sarojini M Joober, Ridha
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Progress in neuro-psychopharmacology & biological psychiatry
This exploratory study aims to determine whether the change in systolic blood pressure (sBP) after acute methylphenidate (MPH) administration (ΔBPMPH) is associated with the neurocognitive response to MPH in the Conners Continuous Performance Test (CPT) in 513 children with ADHD (aged 6 to 12 years old). We noted that higher increases in sBP were a...
Montagud-Romero, Sandra Montesinos, Jorge Pavón, Francisco Javier Blanco-Gandia, M Carmen Ballestín, Raúl Rodríguez de Fonseca, Fernando Miñarro, José Guerri, Consuelo Rodríguez-Arias, Marta
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Progress in neuro-psychopharmacology & biological psychiatry
Social stress is associated with higher vulnerability to drug use, as it enhances the reinforcing effects of psychostimulants in rodents. Furthermore, continued or severe stress induces a proinflammatory state of microglial activation and augmented cytokine production. The aim of the present work was to evaluate the role of fractalkine [C-X3-C moti...
Donner, Nina C Davies, Sofia M Fitz, Stephanie D Kienzle, Drake M Shekhar, Anantha Lowry, Christopher A
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Progress in neuro-psychopharmacology & biological psychiatry
The bed nucleus of the stria terminalis (BNST) is a nodal structure in neural circuits controlling anxiety-related defensive behavioral responses. It contains neurons expressing the stress- and anxiety-related neuropeptide corticotropin-releasing hormone (Crh) as well as Crh receptors. Repeated daily subthreshold activation of Crh receptors in the ...
Wang, JiaJia Li, YanJun Lai, Ke Zhong, QiMei Demin, Konstantin A Kalueff, Allan V Song, Cai
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Progress in neuro-psychopharmacology & biological psychiatry
Neuroinflammation and metabolic deficits contribute to the etiology of human affective disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism in CNS disease modeling. Here, we exposed zebrafish to 2% glucose and 10% cholesterol for 19 days to experimentally induce type 2 diabetes...
Kuehl, Linn K Deuter, Christian E Hellmann-Regen, Julian Kaczmarczyk, Michael Otte, Christian Wingenfeld, Katja
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Progress in neuro-psychopharmacology & biological psychiatry
Major depressive disorder (MDD) has been associated with changes in the biological stress systems, including the locus coeruleus-noradrenergic system. Accumulated evidence suggests an upregulation of central alpha2-receptors, leading to decreased noradrenergic activity on a central level in MDD patients. Adverse childhood experiences (ACE) such as ...
Schiavone, Stefania Morgese, Maria Grazia Bove, Maria Colia, Anna Laura Maffione, Angela Bruna Tucci, Paolo Trabace, Luigia Cuomo, Vincenzo
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Progress in neuro-psychopharmacology & biological psychiatry
Administration in adulthood of subanaesthetic doses of ketamine, an NMDA receptor (NMDA-R) antagonist, is commonly used to induce psychotic-like alterations in rodents. The NADPH oxidase (NOX) derived-oxidative stress has been shown to be implicated in ketamine-induced neurochemical dysfunctions and in the loss of parvalbumin (PV)-positive interneu...
Odeon, María Mercedes Acosta, Gabriela Beatriz
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Progress in neuro-psychopharmacology & biological psychiatry
Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasma...
Hennings, Johannes M Kohli, Martin A Uhr, Manfred Holsboer, Florian Ising, Marcus Lucae, Susanne
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Progress in neuro-psychopharmacology & biological psychiatry
Major depression is a stress-related disorder with robust clinical and preclinical data implicating that both, dysregulation of the hypothalamus-pituitary-adrenocortical (HPA) axis and of the neurotrophin system of the brain are involved in the pathophysiology. Genetic variations within the brain-derived neurotrophic factor (BDNF) gene region, a ma...
