Tran, Steven Gerlai, Robert
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•The zebrafish is becoming increasingly appreciated in alcohol research.•Acute and chronic alcohol administration induced behavioral changes seen in zebrafish•Constant exposure to low alcohol concentrations induces tolerance in zebrafish.•Repeated exposure to high alcohol concentrations induces sensitization in zebrafish.•Biological correlates unde...
Kalueff, Allan V. Echevarria, David Stewart, Adam Michael
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•Translational neuroscience is becoming critical to understand complex brain disorders•Zebrafish are a useful model organism in neuroscience research ‘from tank to bedside’•Zebrafish models have multiple advantages for modeling complex CNS traits and processes•More zebrafish models will foster translational neuroscience and biopsychiatry research
Nguyen, Michael Stewart, Adam Michael Kalueff, Allan V.
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•Depression is a common and debilitating neuropsychiatric mood disorder•Animal models are an invaluable tool for research into the depression pathogenesis•Zebrafish represent a useful model organism for studying depression•Zebrafish are a useful model for anti-depressant drug discovery
Barbiero, Janaína K. Santiago, Ronise Tonin, Fernanda S. Boschen, Suelen da Silva, Luísa Mota de Paula Werner, Maria Fernanda da Cunha, Claudio Lima, Marcelo M.S. Vital, Maria A.B.F.
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•The oral administration of Fenofibrate decreased the hypolocomotion in MPTP-lesioned rats.•Fenofibrate was able to decrease depressive-like behavior in the forced swim test in MPTP-lesioned rats•Oxidative stress was reduced after the Fenofibrate treatment in MPTP-lesioned rats.
Wang, Kai Sun, Siyuan Li, Liping Tu, Meijuan Jiang, Huidi
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•We evaluated OCT2 inhibition as a potential mechanism of antidepressant action in a stably expressed cell model MDCK-hOCT2;•We further explored inhibition mechanism of two antidepressants on OCT2;•We proposed possible involvement of uptake 2 pathway in the antidepressant action of piperine.
Zhang, Zhang-Jin Wang, Di Man, Sui Cheung Ng, Roger McAlonan, Grainne M. Wong, Hei Kiu Wong, Wendy Lee, Jade Tan, Qing-Rong
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•Patients with MDD had higher platelet 5-HT1A receptor expression than controls•Patients with MDD had lower 5-HT and 5- HIAA levels than controls•SERT expression did not differ between the two groups•Platelet 5-HT1A receptor expression is negatively correlated with the 5-HT and 5-HIAA levels.
de Macêdo Medeiros, André Izídio, Geison Souza Sousa, Diego Silveira Macedo, Priscila Tavares Silva, Anatildes Feitosa Shiramizu, Victor Kenji Medeiros Cabral, Alicia Ribeiro, Alessandra Mussi Silva, Regina Helena
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•Scopolamine induced learning impairment specifically in diestrus.•Scopolamine-induced learning impairment was prevented by exogenous estradiol.•Posttraining estradiol potentiated the memory impairment induced by scopolamine.•A role of the cholinergic system is suggested for the estrogen mechanisms on memory.
Wang, Huikun Lupica, Carl R.
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•The literature regarding the role of endogenous cannabinoids in brain reward circuits is reviewed.•We propose that endogenous cannabinoids are released from mid-brain dopamine neurons during periods of increased excitability.•We propose that endocannabinoids act within the ventral mid-brain to regulate dopamine function in the forebrain.•We propos...
Kollins, Scott H. Adcock, R. Alison
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•ADHD is a risk factor for adverse outcomes related to cigarette smoking.•ADHD is associated with altered dopamine neurotransmission.•ADHD is associated with disrupted reinforcement processes.•ADHD smoking risk can be clarified by studying dopamine-reinforcement links.
Xiong, Yuyu Wei, Zhiyun Huo, Ran Wu, Xi Shen, Lu Li, Yang Gong, Xueli Wu, Zhenqiang Feng, Guoyin Li, Wenqiang
...
Published in
Progress in Neuropsychopharmacology & Biological Psychiatry
•We recruit two cohorts of Chinese schizophrenic patients from two geographic areas.•We detect significant effect of CCL2 polymorphisms with risperidone response.•Population stratification may have influenced the results.
