Nguyen, Michael Stewart, Adam Michael Kalueff, Allan V
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Depression is a serious psychiatric condition affecting millions of patients worldwide. Unipolar depression is characterized by low mood, anhedonia, social withdrawal and other severely debilitating psychiatric symptoms. Bipolar disorder manifests in alternating depressed mood and 'hyperactive' manic/hypomanic states. Animal experimental models are...
Kalueff, Allan V Echevarria, David J Stewart, Adam Michael
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Zebrafish (Danio rerio) are rapidly becoming a popular model organism in translational neuroscience and biological psychiatry research. Here we discuss conceptual, practical and other related aspects of using zebrafish in this field ("from tank to bedside"), and critically evaluate both advantages and limitations of zebrafish models of human brain ...
Tran, Steven Gerlai, Robert
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Alcohol abuse and dependence are a rapidly growing problem with few treatment options available. The zebrafish has become a popular animal model for behavioral neuroscience. This species may be appropriate for investigating the effects of alcohol on the vertebrate brain. In the current review, we examine the literature by discussing how alcohol alt...
de Macêdo Medeiros, André Izídio, Geison Souza Sousa, Diego Silveira Macedo, Priscila Tavares Silva, Anatildes Feitosa Shiramizu, Victor Kenji Medeiros Cabral, Alicia Ribeiro, Alessandra Mussi Silva, Regina Helena
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Previous studies suggested that estrogen plays a role in cognitive function by modulating the cholinergic transmission. However, most of the studies dealing with this subject have been conducted using ovariectomized rats. In the present study we evaluated the effects of physiological and supra-physiological variation of estrogen levels on scopolami...
Barbiero, Janaína K Santiago, Ronise Tonin, Fernanda S Boschen, Suelen da Silva, Luísa Mota Werner, Maria Fernanda de Paula da Cunha, Claudio Lima, Marcelo M S Vital, Maria A B F
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The etiology and pathogenesis of PD are still unknown, however, many evidences suggest a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and p...
Wang, Kai Sun, Siyuan Li, Liping Tu, Meijuan Jiang, Huidi
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Novel antidepressants or treatment strategies that may offer a more rapid onset of action, improved efficacy, and greater tolerability are in desperate need. Because current clinically utilized antidepressants, which target high-affinity transporters for serotonin and norepinephrine, fail to provide satisfactory treatment outcomes for quite a porti...
Zhang, Zhang-Jin Wang, Di Man, Sui Cheung Ng, Roger McAlonan, Grainne M Wong, Hei Kiu Wong, Wendy Lee, Jade Tan, Qing-Rong
Published in
Progress in neuro-psychopharmacology & biological psychiatry
The platelet serotonergic system has potential biomarker utility for major depressive disorder (MDD). In the present study, platelet expression of 5-HT1A receptors and serotonin transporter (SERT) proteins, and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were quantified in 53 patients with MDD and 22 unaffected controls....
Wang, Huikun Lupica, Carl R
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Endogenous cannabinoids play important roles in a variety of functions in the mammalian brain, including the regulation reward-related information processing. The primary mechanism through which this is achieved is the presynaptic modulation of synaptic transmission. During reward- and reinforcement-related behavior dopamine levels increase in fore...
Kollins, Scott H Adcock, R Alison
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Attention deficit hyperactivity disorder (ADHD) is a common and impairing disorder affecting millions of children, adolescents, and adults. Individuals with ADHD smoke cigarettes at rates significantly higher than their non-diagnosed peers and the disorder also confers risk for a number of related adverse smoking outcomes including earlier age of i...
Bustamante-García, R Lira-Rocha, A S Espejo-González, O Gómez-Martínez, A E Picazo, O
Published in
Progress in neuro-psychopharmacology & biological psychiatry
In spite of the wide variety of drugs available for treating anxiety, this disorder continues to represent a worldwide health problem that is classified within the first 10 causes of disability. Therefore, the search continues for new antianxiety agents, particularly those not related to benzodiazepines. Even though melatonin has been prescribed as...
