Introduction: low-saturated fat, high-carbohydrate diets: effects on triglyceride and LDL synthesis, the LDL receptor, a...
One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjec...
Restriction of all dietary fat is a popular strategy for restricting saturated fat intake to lower LDL cholesterol. Some authorities advise the restriction of fat intake to the extreme of less than 10% of daily energy on the assumption that more fat restriction is better. The two studies described herein address questions relating to whether increa...
Renal function and glucose transport in male and female mice with diet-induced type II diabetes mellitus.
The aim of this study was to measure cardiovascular and renal function, including the renal transport capacity for glucose, in male and female C57BL/6J mice with diet-induced Type II diabetes mellitus. Typical of Type II diabetes, mice fed a high-fat, high-simple carbohydrate diet for 3 months were obese (45-65 g), hyperglycemic (138-259 mg%), and ...
Effect of high-carbohydrate feeding on triglyceride and saturated fatty acid synthesis.
It has been known for decades that low-fat, high-carbohydrate diets can increase plasma triglyceride levels, but the mechanism for this effect has been uncertain. Recently, new isotopic and nonisotopic methods have been used to determine in vivo whether low-fat, high-carbohydrate diets increase triglyceride levels by stimulating fatty acid synthesi...
Unsaturated fatty acids inhibit sterol regulatory element-dependent gene expression: a potential mechanism contributing ...
Nitric oxide donors.
Nitric oxide (NO) donors are pharmacologically active substances that release NO in vivo or in vitro. NO has a variety of functions such as the release of prostanoids, inhibition of platelet aggregation, effect on angiogenesis, and production of oxygen free radicals. This report discusses the chemical and pharmacological characteristics of NO donor...
Characterization of the calcium signaling system in the submandibular cell line SMG-C6.
Establishment of salivary cell lines retaining normal morphological and physiological characteristics is important in the investigation of salivary cell function. A submandibular gland cell line, SMG-C6, has recently been established. In the present study, we characterized the phosphoinositide (PI)-Ca2+ signaling system in this cell line. Inositol ...
Melatonin and the synthesis of vasopressin in pinealectomized male rats.
The pineal hormone, melatonin, is known to modify, under different experimental conditions, neurohypophysial hormone secretion in the rat. The aim of this study was to investigate the effect of melatonin on the vasopressin biosynthesis rate in the hypothalamus of either pinealectomized or sham-operated rats, using the colchicine method. To estimate...
Will high-carbohydrate/low-fat diets reduce the risk of coronary heart disease?
Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular...
Cell death induction by cytotoxic T lymphocytes (CTLs) is an important thesis for the understanding of tumor immunotherapy. In the current study we investigated the molecular machinery of CTL-induced cell death in human hepatocellular carcinoma cell lines (HCC lines). CTLs prepared from human peripheral blood induced cell death in all tested HCC li...
