Motiño, Omar Lambertucci, Flavia Anagnostopoulos, Gerasimos Li, Sijing Nah, Jihoon Castoldi, Francesca Senovilla, Laura Montégut, Léa Chen, Hui Durand, Sylvère
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Acyl-coenzyme A (CoA)-binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and ...
Ming Yip, Hon Cheng, Shiyu Olson, Evan J. Crone, Michael Maerkl, Sebastian J.
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Proceedings of the National Academy of Sciences of the United States of America
Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Saccharomyces cerevisiae Pho regulon. When external inorganic phosphate ( P i ) concentration is low, the Pho regulon activates, expressing genes that scave...
Brabender, Max Henriques Pereira, Delfina P. Mrnjavac, Natalia Schlikker, Manon Laura Kimura, Zen-Ichiro Sucharitakul, Jeerus Kleinermanns, Karl Tüysüz, Harun Buckel, Wolfgang Preiner, Martina
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Proceedings of the National Academy of Sciences of the United States of America
Autotrophic theories for the origin of metabolism posit that the first cells satisfied their carbon needs from CO2 and were chemolithoautotrophs that obtained their energy and electrons from H2. The acetyl-CoA pathway of CO2 fixation is central to that view because of its antiquity: Among known CO2 fixing pathways it is the only one that is i) exer...
Kong, Xuhui Li, Ruiqi Chen, Manqi Zheng, Rongyan Wang, Jichang Sun, Chuanbo Qu, Yuliang
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Proceedings of the National Academy of Sciences of the United States of America
Endogenous retroviruses (ERVs) are frequently reactivated in mammalian placenta. It has been proposed that ERVs contribute to shaping the gene regulatory network of mammalian trophoblasts, dominantly acting as species- and placental-specific enhancers. However, whether and how ERVs control human trophoblast development through alternative pathways ...
Hagemann, Julia R Lamy, Frank Arz, Helge W Lembke-Jene, Lester Auderset, Alexandra Harada, Naomi Ho, Sze Ling Iwasaki, Shinya Kaiser, Jérôme Lange, Carina B
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Proceedings of the National Academy of Sciences of the United States of America
Terrestrial glacial records from the Patagonian Andes and New Zealand Alps document quasi-synchronous Southern Hemisphere-wide glacier advances during the late Quaternary. However, these records are inherently incomplete. Here, we provide a continuous marine record of western-central Patagonian ice sheet (PIS) extent over a complete glacial-intergl...
Skrbek, Ladislav Schmoranzer, David Sreenivasan, Katepalli R
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Proceedings of the National Academy of Sciences of the United States of America
Transition from laminar to turbulent states of classical viscous fluids is complex and incompletely understood. Transition to quantum turbulence (QT), by which we mean the turbulent motion of quantum fluids such as helium II, whose physical properties depend on quantum physics in some crucial respects, is naturally more complex. This increased comp...
Amankwah, Yaa S Fleifil, Yasmeen Unruh, Erin Collins, Preston Wang, Yi Vitou, Katherine Bates, Alison Obaseki, Ikponwmosa Sugoor, Meghana Alao, John Paul
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Proceedings of the National Academy of Sciences of the United States of America
Hsp90s are ATP-dependent chaperones that collaborate with co-chaperones and Hsp70s to remodel client proteins. Grp94 is the ER Hsp90 homolog essential for folding multiple secretory and membrane proteins. Grp94 interacts with the ER Hsp70, BiP, although the collaboration of the ER chaperones in protein remodeling is not well understood. Grp94 under...
Silberstein, John L Du, Jasper Chan, Kun-Wei Frank, Jessica A Mathews, Irimpan I Kim, Yong Bin You, Jia Lu, Qiao Liu, Jia Philips, Elliot A
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Proceedings of the National Academy of Sciences of the United States of America
Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed on activated T cells and an emerging immunotherapy target. Domain 1 (D1) of LAG-3, which has been purported to directly interact with major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1), has been the major focus for the development of therape...
Tian, Peipei Feng, Kuishuang Sun, Laixiang Hubacek, Klaus Malerba, Daniele Zhong, Honglin Zheng, Heran Li, Dan Zhang, Ning Li, Jiashuo
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Proceedings of the National Academy of Sciences of the United States of America
Addressing the total energy cost burden of elderly people is essential for designing equitable and effective energy policies, especially in responding to energy crisis in an aging society. It is due to the double impact of energy price hikes on households-through direct impact on fuel bills and indirect impact on the prices of goods and services co...
Xu, Mingkai Wang, Ruizhao Fu, Haoyang Shi, Yanbiao Ling, Lan
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Proceedings of the National Academy of Sciences of the United States of America
Manipulating exciton dissociation and charge-carrier transfer processes to selectively generate free radicals of more robust photocatalytic oxidation capacity for mineralizing refractory pollutants remains challenging. Herein, we propose a strategy by simultaneously introducing the cyano-group and Na into graphitic carbon nitride (CN) to obtain CN-...
