Tantry, Udaya S Hartmann, Jan Neal, Matthew D Schöechl, Herbert Bliden, Kevin P Agarwal, Seema Mason, Dan Dias, Joao D Mahla, Elisabeth Gurbel, Paul A
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Published in
Platelets
We carried out a literature search in MEDLINE (PubMed) and EMBASE literature databases to provide a concise review of the role of viscoelastic testing in assessing peri-interventional platelet function and coagulation. The search identified 130 articles that were relevant for the review, covering the basic science of VHA and VHA in clinical setting...
Zhou, Hui Li, Zhifeng Liang, Hui Yan, Zhengzheng
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Platelets
Thrombocytopenia is common in critical illness. But there are no studies that focus on thrombocytopenia and platelet recovery in Sepsis-3 patients. We employed a large database to identify sepsis based on Sepsis-3 criteria. Patients were grouped by nadir platelet count during ICU, propensity score matching was used to eliminate covariates imbalance...
Li, Yi Feng, Ziqian Zhu, Luochen Chen, Ni Wan, Qin Wu, Jianbo
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Platelets
Stromal cell-derived factor 1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have shown to play a role in the homing and engraftment of hematopoietic stem and progenitor cells. SDF-1 is highly expressed in platelets and involved in thrombosis formation. However, the exact roles of platelet-derived SDF-1 and CXCR4 in platelet activation and mi...
Smal, Mary A Baldo, Brian A
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Platelets
Experiments were undertaken to identify the nature of a previously identified inhibitor of PAF-induced platelet aggregation (PA) in human saliva. Human saliva fractionated by preparative thin layer chromatography (TLC) yielded a fraction that co-migrated with fatty acids (FAs) and inhibited PAF-induced aggregation of platelets. Synthetic FAs tested...
Lv, Mei-Na Zheng, Xiao-Chun Jiang, Shao-Jun Zhang, Hong-Qin Xu, Fang-Da Wu, Ting-Ting Chen, Wen-Jun Zhang, Jin-Hua
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Platelets
Gastrointestinal bleeding (GIB) is the most common serious bleeding complication of antiplatelet therapy. The bleeding risk score (BRS) of GIB may help to determine the risk of bleeding, and provides a reference for the formulation of antiplatelet therapy regimen in clinical practice, but we found that no specific risk scores are available in East ...
Koker, M Y Sarper, N Albayrak, C Zulfikar, B Zengin, E Saraymen, B Albayrak, D Koc, B Avcilar, H Karakükcü, M
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Platelets
Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder characterized by impaired platelet aggregation due to defects in integrin αIIbβ3, a fibrinogen receptor. Platelet phenotypes and allelic variations in 28 Turkish GT patients are reported. Platelets αIIbβ3 expression was evaluated by flow cytometry. Sequence analyzes of IT...
Božič, Darja Vozel, Domen Hočevar, Matej Jeran, Marko Jan, Zala Pajnič, Manca Pađen, Ljubiša Iglič, Aleš Battelino, Saba Kralj-Iglič, Veronika
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Platelets
In order to prepare optimal platelet and extracellular vesicle (EV)-rich plasma for the treatment of chronic temporal bone inflammation, we studied effects of centrifugation parameters on redistribution of blood constituents in blood samples of 23 patients and 20 volunteers with no record of disease. Concentrations of blood cells and EVs were measu...
Yu, Shicheng Li, Miaonan Li, Zheng Xu, Pan Yao, Zhuoya Qian, Shaohuan Qian, Fudong Gao, Dasheng Wang, Hongju
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Platelets
Bactericidal/permeability-increasing protein (BPI) exhibits a number of important characteristics. RNA-seq analysis revealed that the BPI expression was increased in platelets of (non)ST-elevated myocardial infarction (NSTEMI/STEMI) patients. Activated platelets can induce NETosis which may be accompanied by the release of myeloperoxidase-DNA (MPO-...
Gąsecka, Aleksandra Zawadka, Mateusz Burban, Anna Idzik, Aleksandra Gelo, Agata Graczyńska, Agata Jama, Katarzyna Filipiak, Krzysztof J Jakimowicz, Tomasz
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Platelets
Endovascular aortic repair (EVAR) an alternative to open surgical repair of thoracoabdominal aortic aneurysm (TAAA). The effect of EVAR on platelet reactivity is unknown. We prospectively determined the effect of branched EVAR (bEVAR) on platelet reactivity in patients with TAAA, and evaluated the predictive value of preoperative platelet reactivit...
Kohs, Tia C L Liu, Patricia Raghunathan, Vikram Amirsoltani, Ramin Oakes, Michael McCarty, Owen J T Olson, Sven R Masha, Luke Zonies, David Shatzel, Joseph J
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Platelets
Extracorporeal membrane oxygenation (ECMO) provides lifesaving circulatory support and gas exchange, although hematologic complications are frequent. The relationship between ECMO and severe thrombocytopenia (platelet count
