Bi, Xiaojie SU, Zhengxian Yan, Haixi Du, Juping Wang, Jing Chen, Linping Peng, Minfei Chen, Shiyong Shen, Bo Li, Jun
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Published in
Platelets
Concomitant coagulation disorder can occur in severe patients withCOVID-19, but in-depth studies are limited. This study aimed to describe the parameters of coagulation function of patients with COVID-19 and reveal the risk factors of developing severe disease. This study retrospectively analyzed 113patients with SARS-CoV-2 infection in Taizhou Pub...
Li, Han Wang, Bangqin Ning, Leping Luo, Yu Xiang, Shulin
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Platelets
EDTA dependent pseudothrombocytopenia (EDTA-PCTP) is a phenomenon that characterized by a spurious decrease of platelets in vitro due to the aggregation of platelets in EDTA anticoagulant blood samples. We report the first case of a transient appearance of EDTA-PCTP in a patient with 2019 novel coronavirus pneumonia (COVID-19). A 59-year-old woman ...
Liu, Yanli Sun, Wenwu Guo, Yanan Chen, Liangkai Zhang, Lijuan Zhao, Su Long, Ding Yu, Li
Published in
Platelets
Background : Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. Methods : The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 in the Central Hospital of W...
Davenport, Patricia Liu, Zhi-Jian Sola-Visner, Martha
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Platelets
A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last decade, studies revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation in neonatal MKs that results in the production of lar...
Lussana, Federico Femia, Eti Alessandra Pugliano, Mariateresa Podda, Gianmarco Razzari, Cristina Maugeri, Norma Lecchi, Anna Caberlon, Sabrina Gerli, Giancarla Cattaneo, Marco
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Published in
Platelets
Background. Studies of platelet aggregation (PA) in essential thrombocythemia (ET) reported contrasting results, likely due to differences in analytical conditions.Objective. We investigated platelet aggregation using different techniques and analytical conditions.Patients and Methods. PA was studied by light-transmission aggregometry (LTA) in plat...
Fedorov, Anton Kondratov, Kirill Kishenko, Vasilii Mikhailovskii, Vladimir Kudryavtsev, Igor Belyakova, Margarita Sidorkevich, Sergey Vavilova, Tatyana Kostareva, Anna Sirotkina, Olga
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Published in
Platelets
Platelet concentrates are used in clinic for therapy and prophylaxis of conditions associated with platelet deficiency or malfunction. The characteristics of platelet concentrates gradually change during pretransfusion storage, affecting their clinical effectiveness and the risk of adverse transfusion reactions. The presence of platelet-derived mem...
Rosinska, Justyna Maciejewska, Joanna Narożny, Robert Osztynowicz, Krystyna Raczak, Beata Michalak, Sławomir Watała, Cezary Kozubski, Wojciech Łukasik, Maria
Published in
Platelets
Platelet-derived microvesicles (pMVs) are released from platelets in physiological and pathological conditions and exhibit a wide range of prothrombotic, antithrombotic, proatherogenic, and pro-inflammatory properties. Antiplatelet agents, such as acetylsalicylic acid (ASA), are widely used for the prevention and treatment of vascular diseases, but...
Kirkpatrick, Angelia C Vincent, Andrea S Dale, George L Prodan, Calin I
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Platelets
Coated-platelets are a subset of highly procoagulant platelets elevated in patients with non-lacunar ischemic stroke and associated with stroke recurrence. Cross-sectional studies in controls have shown that smoking is associated with higher coated-platelet levels while chronic use of serotonin reuptake inhibitors (SSRIs), statins or aspirin is ass...
Nielsen, Camilla Brødsgaard Nielsen, Christian Nybo, Mads Just, Søren Andreas Vinholt, Pernille Just
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Platelets
Several antirheumatic drugs lower the cardiovascular risk among rheumatoid arthritis patients. It is, however, unknown whether inhibition of platelet function contributes to this risk reduction. Only few studies have investigated the potential role of platelets as a target of antirheumatic drugs. In this study, platelet function was tested in vitro...
Garabet, Lamya Ghanima, Waleed Rangberg, Anbjørg Teruel-Montoya, Raul Martinez, Constantino Lozano, Maria Luisa Nystrand, Camilla F Bussel, James B Sandset, Per Morten Jonassen, Christine M
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Platelets
MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. Dysregulated expression of several miRNAs has been found in primary immune thrombocytopenia (ITP) suggesting that miRNAs are likely involved in the pathogenesis of ITP. We aimed to explore the differential expression of miRNAs in patients with ITP before and...
