Halici-Ozturk, Filiz Ocal, Fatma Doga Aydin, Selvi Tanacan, Atakan Ayhan, Sule Göncü Altinboga, Orhan Dinc, Bedia Moraloglu, Özlem Tekin Sahin, Dilek
Published in
Placenta
Introduction The possibility of vertical transmission of SARS-CoV-2 from the mother to the fetus is one of the most crucial issues regarding the COVID-19 effects on pregnancy. In this study, we aimed to explore the risk of maternal-fetal transmission before 24 weeks of gestation, through analysis of abortion materials collected from PCR-positive wo...
Mao, Quanfu Chu, Sharon Shapiro, Svetlana Bliss, Joseph M. De Paepe, Monique E.
Published in
Placenta
• TAPS placentas show discordant expression of ACE2. • TAPS placentas display discordant expression of SARS-CoV-2 cell entry regulators. • Expression of SARS-CoV-2 cell entry regulators is oxygenation-dependent.
Abe, Yushi Ochiai, Daigo Sato, Yu Otani, Toshimitsu Fukutake, Marie Ikenoue, Satoru Kasuga, Yoshifumi Tanaka, Mamoru
Published in
Placenta
Even in the context of modern medicine, infants with fetal and neonatal neurological diseases such as cerebral palsy and myelomeningocele suffer serious long-lasting impairment due to the irreversible neuronal damage. The promotion of neurologically intact survival in patients with perinatal intractable neurological diseases requires the developmen...
Linehan, Laura O'Donoghue, Keelin Dineen, Susan White, Jessica Higgins, John R Fitzgerald, Brendan
Published in
Placenta
We present a case of third trimester pregnancy complicated by SARS-CoV-2 infection and subsequent reduced fetal movements, resulting in emergency Caesarean delivery with demonstrable placental SARS-CoV-2 placentitis. We show through illustration of this case and literature review that SARS-Co-V-2 placentitis is an uncommon but readily recognisable ...
Hasija, Aayushi Balyan, Kirti Debnath, Ekta V, Ravi Kumar, Manisha
Published in
Placenta
To evaluate the role of placental profile markers in second and third trimester of pregnancy in predicting hypertensive disorders of pregnancy (HDP) in women at high risk of preeclampsia. Women who were at high risk of preeclampsia underwent βhCG, ultrasound assessment of placental length, thickness and its ratio, uterine artery Doppler at 20-24 we...
Meakin, Ashley S Morrison, Janna L Bradshaw, Emma L Holman, Stacey L Saif, Zarqa Gatford, Kathryn L Wallace, Megan J Bischof, Robert J Moss, Timothy J M Clifton, Vicki L
...
Published in
Placenta
Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were de...
Mao, Yan Hou, Bin Shan, Long Sun, Xiaotong Wang, Li
Published in
Placenta
Preeclampsia is one of the main causes of morbidity and mortality in pregnant women and mothers. Numerous studies showed that microRNAs (miRNAs) played important roles in the occurrence and development of preeclampsia. However, the regulation of microRNA-142-3p (miR-142-3p) in preeclampsia has not been clarified. The expression of miR-142-3p and FO...
Schakenraad, L Van Es, M J Meerman, J J Van den Broek, P H H Van Hove, H Van Drongelen, J Eliesen, G A M Russel, F G M Greupink, R
Published in
Placenta
An increasing number of women becomes pregnant while suffering from chronic kidney disease (CKD). As a result of decreased renal function, uremic solutes circulate at high levels in the maternal circulation. This study aimed to acquire more knowledge about the placental transfer of uremic solutes across the human placenta. Placental transfer was st...
Li, Wen-Jiao Lu, Jiang-Wen Zhang, Chu-Yue Wang, Wang-Sheng Ying, Hao Myatt, Leslie Sun, Kang
Published in
Placenta
Prostaglandin E2 (PGE2) and F2α (PGF2α) are the two most prominent prostanoids in parturition. They are involved in cervical ripening, membrane rupture, myometrial contraction and inflammation in gestational tissues. Because multiple receptor subtypes for PGE2 and PGF2α exist, coupled with diverse signaling pathways, the effects of PGE2 and PGF2α d...
Dietrich, B Kunihs, V Haider, S Pollheimer, J Knöfler, M
Published in
Placenta
JEG-3 choriocarcinoma cells have been widely used as a model for placental trophoblast. Herein, 3-dimensional (3D) JEG-3 organoids (JEG-3-ORGs) were established using a protocol that we recently developed for primary cytotrophoblast organoids (CTB-ORGs). 3D JEG-3-ORGs, cultivated in basic culture medium, rapidly divide and spontaneously undergo dif...