Vazhappilly, Cijo George Hodeify, Rawad Siddiqui, Shoib Sarwar Laham, Amina Jamal Menon, Varsha El-Awady, Raafat Matar, Rachel Merheb, Maxime Marton, John Al Zouabi, Hussain Abdel Karim
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Phytotherapy research : PTR
Targeting cell cycle and inducing DNA damage by activating cell death pathways are considered as effective therapeutic strategy for combating breast cancer progression. Many of the naturally known small molecules target these signaling pathways and are effective against resistant and/or aggressive types of breast cancers. Here, we investigated the ...
Ghasemzadeh Rahbardar, Mahboobeh Razavi, Bibi Marjan Hosseinzadeh, Hossein
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Phytotherapy research : PTR
Mangosteen fruit has been used for various disorders, including pain. The effects of alpha-mangostin, the main component of mangosteen, on the neuropathic pain caused by chronic constriction injury (CCI) were evaluated in rats. In treatment groups, alpha-mangostin (10, 50, 100 mg/kg/day, i.p.) was administered from Day 0, the day of surgery, for 14...
Yang, Fan Zhang, Yue Tariq, Akash Jiang, Xiaolan Ahmed, Zeeshan Zhihao, Zhang Idrees, Muhammad Azizullah, Azizullah Adnan, Muhammad Bussmann, Rainer W
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Phytotherapy research : PTR
The recent and ongoing outbreak of coronavirus disease (COVID-19) is a huge global challenge. The outbreak, which first occurred in Wuhan City, Hubei Province, China and then rapidly spread to other provinces and to more than 200 countries abroad, has been declared a global pandemic by the World Health Organization. Those with compromised immune sy...
Koop, Tina Dienel, Angelika Heldmann, Marcus Münte, Thomas F
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Phytotherapy research : PTR
Rhodiola rosea extract is widely used to alleviate stress and improve cognition and mental resources. A total of 50 adult participants were treated with 2 × 200 mg R. rosea extract (Rosalin®, WS® 1,375) for 12 weeks and were subjected to a neuropsychological test battery as well as an event-related brain potential measurement in a dual task paradig...
Foroutanfar, Amir Mehri, Soghra Kamyar, Marzyeh Tandisehpanah, Zahra Hosseinzadeh, Hossein
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Phytotherapy research : PTR
Acrylamide (ACR) is widely used in industries. Oxidative stress and apoptosis pathways are important mechanisms behind ACR-induced hepatotoxicity and neurotoxicity. Regarding to antioxidant and antiapoptotic properties of punicalagin (PUN), the protective effect of this agent on ACR-induced toxicity in rat was evaluated. Rats were divided into seve...
Ahmed, Ayaz Zeng, Guirong Azhar, Mudassar Lin, Haiying Zhang, Mijia Wang, Fengzhong Zhang, Hong Jiang, Dejian Yang, Sijin Farooq, Ahsana Dar
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Phytotherapy research : PTR
Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containing Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J-SMS) was screen...
Zhang, Yu Li, Fei Jiang, Xi Jiang, Xiqian Wang, Yahui Zhang, Haiyan Zhang, Li Fan, Shengjie Xin, Lianjun Yang, Baican
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Phytotherapy research : PTR
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by the accumulation of triglycerides and associated with obesity, hyperlipidemia and insulin resistance. Currently, there is no therapy for NAFLD. Emerging evidences suggest that the inhibition of liver X receptor (LXR) activity may be a potential therapy for hepatic ...
Yang, Hongbao Said, Abdullahi Mohamed Huang, Huimin Papa, Akuetteh Percy David Jin, Guihua Wu, Shijia Ma, Nengfang Lan, Linhua Shangguan, Fugen Zhang, Qiyu
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Phytotherapy research : PTR
Pancreatic ductal adenocarcinoma (PDAC) is severe malignant tumor in human, the outcomes of PDAC is extremely poor. Here, we evaluated the potential anti-tumor activity of chlorogenic Acid (CA) in PDAC. Here, we found CA was effective to suppress PDAC cell growth in vitro and in vivo. Importantly, we found overall oxygen consumption rate was signif...
Hoang, Tung
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Phytotherapy research : PTR
Mokhtari, Mehrdad Razzaghi, Reza Momen-Heravi, Mansooreh
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Phytotherapy research : PTR
This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), rec...
