Havariyoun, Glafkos Vittoria, Fabio A Hagen, Charlotte K Basta, Dario Kallon, Gibril K Endrizzi, Marco Massimi, Lorenzo Munro, Peter Hawker, Sam Smit, Bennie
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Published in
Physics in medicine and biology
A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal carcinoma in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development of a c...
Bertholet, Jenny Knopf, Antje Eiben, Björn McClelland, Jamie Grimwood, Alexander Harris, Emma Menten, Martin Poulsen, Per Nguyen, Doan Trang Keall, Paul
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Physics in medicine and biology
Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to ac...
Lee, Boon Q Abbott, Elliot M Able, Sarah Thompson, James M Hill, Mark A Kartsonaki, Christiana Vallis, Katherine A Falzone, Nadia
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Physics in medicine and biology
Approximately 50% of all colorectal cancer (CRC) patients will develop metastasis to the liver. 90Y selective internal radiation therapy (SIRT) is an established treatment for metastatic CRC. There is still a fundamental lack of understanding regarding the radiobiology underlying the dose response. This study was designed to determine the radiosens...
Gurney-Champion, Oliver J Collins, David J Wetscherek, Andreas Rata, Mihaela Klaassen, Remy van Laarhoven, Hanneke W M Harrington, Kevin J Oelfke, Uwe Orton, Matthew R
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Physics in medicine and biology
Despite the utility of tumour characterisation using quantitative parameter maps from multi-b-value diffusion-weighted MRI (DWI), clinicians often prefer the use of the image with highest diffusion-weighting (b-value), for instance for defining regions of interest (ROIs). However, these images are typically degraded by noise, as they do not utilize...
Moghimirad, Elahe Bamber, Jeffrey Harris, Emma
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Physics in medicine and biology
Contrast enhanced ultrasound (CEUS) and dynamic contrast enhanced ultrasound (DCE-US) can be used to provide information about the vasculature aiding diagnosis and monitoring of a number of pathologies including cancer. In the development of a CEUS imaging system, there are many choices to be made, such as whether to use plane wave (PW) or focused ...
Menten, Martin J Fast, Martin F Wetscherek, Andreas Rank, Christopher M Kachelrieß, Marc Collins, David J Nill, Simeon Oelfke, Uwe
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Physics in medicine and biology
2D cine MR imaging may be utilized to monitor rapidly moving tumors and organs-at-risk for real-time adaptive radiotherapy. This study systematically investigates the impact of geometric imaging parameters on the ability of 2D cine MR imaging to guide template-matching-driven autocontouring of lung tumors and abdominal organs. Abdominal 4D MR image...
Tsang, H S Kamerling, C P Ziegenhein, P Nill, S Oelfke, U
Published in
Physics in Medicine and Biology
Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability that sufficient dose is delivered to the CTV, it can also result in delivering high dose of radiation to surrounding organs ...
Cole, A J Veiga, C Johnson, U D'Souza, D Lalli, N K McClelland, J R
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Physics in medicine and biology
Changes in lung architecture during a course of radiotherapy can alter the planned dose distribution to the extent that it becomes clinically unacceptable. This study aims to validate a quantitative method of determining whether a replan is required during the course of conformal radiotherapy. The proposed method uses deformable image registration ...
Godinez, Felipe Chaudhari, Abhijit J Yang, Yongfeng Farrell, Richard Badawi, Ramsey D
Published in
Physics in medicine and biology
The aim of this study is to design and test a new high-resolution hybrid depth of interaction (DOI) detector for a dedicated breast PET/CT scanner. Two detectors have been designed and built. The completed detectors are based on a 14 × 14 array of 1.5 × 1.5 × 20 mm(3) unpolished lutetium orthosilicate scintillation crystals, with each element coate...
Afsharpour, Hossein Pignol, Jean-Philippe Keller, Brian Carrier, Jean-François Reniers, Brigitte Verhaegen, Frank Beaulieu, Luc
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Physics in Medicine and Biology
The impact of tissue heterogeneity and interseed attenuation is studied in post-implant evaluation of five clinical permanent breast (103)Pd seed implants using the Monte Carlo (MC) dose calculation method. Dose metrics for the target (PTV) as well as an organ at risk (skin) are used to visualize the differences between a TG43-like MC method and mo...
