Davey, Angela van Herk, Marcel Faivre-Finn, Corinne Brown, Sean McWilliam, Alan
Published in
Physics in Medicine and Biology
Purpose . 4D-CT is routine imaging for lung cancer patients treated with stereotactic body radiotherapy. No studies have investigated optimal 4D phase selection for radiomics. We aim to determine how phase data should be used to identify prognostic biomarkers for distant failure, and test whether stability assessment is required. A phase selection ...
Collins-Fekete, Charles-Antoine Dikaios, Nikolaos Bär, Esther Evans, Philip M
Published in
Physics in Medicine and Biology
In this study, we investigated the capacity of various ion beams available for radiotherapy to produce high quality relative stopping power map acquired from energy-loss measurements. The image quality metrics chosen to compare the different ions were signal-to-noise ratio (SNR) as a function of dose and spatial resolution. Geant4 Monte Carlo simul...
Veiga, Catarina Lim, Pei Anaya, Virginia Marin Chandy, Edward Ahmad, Reem D’Souza, Derek Gaze, Mark Moinuddin, Syed Gains, Jennifer
Published in
Physics in Medicine and Biology
Reducing radiation-induced side effects is one of the most important challenges in paediatric cancer treatment. Recently, there has been growing interest in using spatial normalisation to enable voxel-based analysis of radiation-induced toxicities in a variety of patient groups. The need to consider three-dimensional distribution of doses, rather t...
Bernstein, David Taylor, Alexandra Nill, Simeon Oelfke, Uwe
Published in
Physics in Medicine and Biology
Target volume delineation uncertainty (DU) is arguably one of the largest geometric uncertainties in radiotherapy that are accounted for using planning target volume (PTV) margins. Geometrical uncertainties are typically derived from a limited sample of patients. Consequently, the resultant margins are not tailored to individual patients. Furthermo...
Rothwell, B C Kirkby, N F Merchant, M J Chadwick, A L Lowe, M Mackay, R I Hendry, J H Kirkby, K J
Published in
Physics in Medicine and Biology
There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxy...
Berne, Alexander Petersson, Kristoffer Tullis, Iain D C Newman, Robert G Vojnovic, Borivoj
Published in
Physics in Medicine and Biology
When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical parameters that determine the dose distribution. Moreover, during such irradiations, linear accelerators (linacs) usually operate with significant beam loading, where a small change in the accele...
Havariyoun, Glafkos Vittoria, Fabio A Hagen, Charlotte K Basta, Dario Kallon, Gibril K Endrizzi, Marco Massimi, Lorenzo Munro, Peter Hawker, Sam Smit, Bennie
...
Published in
Physics in medicine and biology
A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal carcinoma in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development of a c...
Bertholet, Jenny Knopf, Antje Eiben, Björn McClelland, Jamie Grimwood, Alexander Harris, Emma Menten, Martin Poulsen, Per Nguyen, Doan Trang Keall, Paul
...
Published in
Physics in medicine and biology
Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is constantly moving due to respiratory, cardiac, gastrointestinal and urinary activity. The long term goal of the RT community to 'see what we treat, as we treat' and to ac...
Lee, Boon Q Abbott, Elliot M Able, Sarah Thompson, James M Hill, Mark A Kartsonaki, Christiana Vallis, Katherine A Falzone, Nadia
Published in
Physics in medicine and biology
Approximately 50% of all colorectal cancer (CRC) patients will develop metastasis to the liver. 90Y selective internal radiation therapy (SIRT) is an established treatment for metastatic CRC. There is still a fundamental lack of understanding regarding the radiobiology underlying the dose response. This study was designed to determine the radiosens...
Freedman, Joshua N Bainbridge, Hannah E Nill, Simeon Collins, David J Kachelrieß, Marc Leach, Martin O McDonald, Fiona Oelfke, Uwe Wetscherek, Andreas
Published in
Physics in medicine and biology
MR-guided radiotherapy treatment planning utilises the high soft-tissue contrast of MRI to reduce uncertainty in delineation of the target and organs at risk. Replacing 4D-CT with MRI-derived synthetic 4D-CT would support treatment plan adaptation on hybrid MR-guided radiotherapy systems for inter- and intrafractional differences in anatomy and res...
