Lee, Boon Q Abbott, Elliot M Able, Sarah Thompson, James M Hill, Mark A Kartsonaki, Christiana Vallis, Katherine A Falzone, Nadia
Published in
Physics in Medicine and Biology
Approximately 50% of all colorectal cancer (CRC) patients will develop metastasis to the liver. 90Y selective internal radiation therapy (SIRT) is an established treatment for metastatic CRC. There is still a fundamental lack of understanding regarding the radiobiology underlying the dose response. This study was designed to determine the radiosens...
Menten, Martin J Fast, Martin F Wetscherek, Andreas Rank, Christopher M Kachelrieß, Marc Collins, David J Nill, Simeon Oelfke, Uwe
Published in
Physics in medicine and biology
2D cine MR imaging may be utilized to monitor rapidly moving tumors and organs-at-risk for real-time adaptive radiotherapy. This study systematically investigates the impact of geometric imaging parameters on the ability of 2D cine MR imaging to guide template-matching-driven autocontouring of lung tumors and abdominal organs. Abdominal 4D MR image...
Tsang, H S Kamerling, C P Ziegenhein, P Nill, S Oelfke, U
Published in
Physics in Medicine and Biology
Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability that sufficient dose is delivered to the CTV, it can also result in delivering high dose of radiation to surrounding organs ...
Cole, A J Veiga, C Johnson, U D’Souza, D Lalli, N K McClelland, J R
Published in
Physics in Medicine and Biology
Changes in lung architecture during a course of radiotherapy can alter the planned dose distribution to the extent that it becomes clinically unacceptable. This study aims to validate a quantitative method of determining whether a replan is required during the course of conformal radiotherapy. The proposed method uses deformable image registration ...
Godinez, Felipe Chaudhari, Abhijit J Yang, Yongfeng Farrell, Richard Badawi, Ramsey D
Published in
Physics in medicine and biology
The aim of this study is to design and test a new high-resolution hybrid depth of interaction (DOI) detector for a dedicated breast PET/CT scanner. Two detectors have been designed and built. The completed detectors are based on a 14 × 14 array of 1.5 × 1.5 × 20 mm(3) unpolished lutetium orthosilicate scintillation crystals, with each element coate...
Afsharpour, Hossein Pignol, Jean-Philippe Keller, Brian Carrier, Jean-François Reniers, Brigitte Verhaegen, Frank Beaulieu, Luc
Published in
Physics in Medicine and Biology
The impact of tissue heterogeneity and interseed attenuation is studied in post-implant evaluation of five clinical permanent breast (103)Pd seed implants using the Monte Carlo (MC) dose calculation method. Dose metrics for the target (PTV) as well as an organ at risk (skin) are used to visualize the differences between a TG43-like MC method and mo...
Jennifer S, Cho Richard, Taschereau Sebastian, Olma Kan, Liu Yi-Chun, Chen Clifton K-F, Shen R Michael, Van Dam Arion F, Chatziioannou
Published in
Physics in Medicine and Biology
Aj, Chaudhari S, Ahn R, Levenson Rd, Badawi Sr, Cherry Rm, Leahy
Published in
Physics in Medicine and Biology
Molecular probes used for in vivo optical fluorescence tomography (OFT) studies in small animals are typically chosen such that their emission spectra lie in the 680-850 nm wavelength range. This is because tissue attenuation in this spectral band is relatively low, allowing optical photons even from deep sites in tissue to reach the animal surface...
Aj, Chaudhari Aa, Joshi Sl, Bowen Rm, Leahy Sr, Cherry Rd, Badawi
Published in
Physics in Medicine and Biology
Modern positron emission tomography (PET) detectors are typically made from 2D modular arrays of scintillation crystals. Their characteristic flood field response (or flood histogram) must be segmented in order to correctly determine the crystal of annihilation photon interaction in the system. Crystal identification information thus generated is a...
Ramsey D. Badawi Marsden, Pk
Published in
Physics in Medicine and Biology
Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode...
