Szmul, Adam Taylor, Sabrina Lim, Pei Cantwell, Jessica Moreira, Isabel Zhang, Ying D’Souza, Derek Moinuddin, Syed Gaze, Mark N. Gains, Jennifer
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Published in
Physics in Medicine & Biology
Objective. Adaptive radiotherapy workflows require images with the quality of computed tomography (CT) for re-calculation and re-optimisation of radiation doses. In this work we aim to improve the quality of on-board cone beam CT (CBCT) images for dose calculation using deep learning. Approach. We propose a novel framework for CBCT-to-CT synthesis ...
Pan, Shaoyan Wang, Tonghe Qiu, Richard L J Axente, Marian Chang, Chih-Wei Peng, Junbo Patel, Ashish B Shelton, Joseph Patel, Sagar A Roper, Justin
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Published in
Physics in Medicine & Biology
Objective. Artificial intelligence (AI) methods have gained popularity in medical imaging research. The size and scope of the training image datasets needed for successful AI model deployment does not always have the desired scale. In this paper, we introduce a medical image synthesis framework aimed at addressing the challenge of limited training ...
Zhao, Lin-mei Zhang, Helen Kim, Daniel D Ghimire, Kanchan Hu, Rong Kargilis, Daniel C Tang, Lei Meng, Shujuan Chen, Quan Liao, Wei-hua
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Published in
Physics in Medicine & Biology
Objective. Radiation therapy for head and neck (H&N) cancer relies on accurate segmentation of the primary tumor. A robust, accurate, and automated gross tumor volume segmentation method is warranted for H&N cancer therapeutic management. The purpose of this study is to develop a novel deep learning segmentation model for H&N cancer based on indepe...
Ge, Gary R Rolland, Jannick P Song, Wei Nedergaard, Maiken Parker, Kevin J
Published in
Physics in Medicine & Biology
Objective. Elastography of the brain has the potential to reveal subtle but clinically important changes in the structure and composition as a function of age, disease, and injury. Approach. In order to quantify the specific effects of aging on mouse brain elastography, and to determine the key factors influencing observed changes, we applied optic...
Xie, Huiqiao Lei, Yang Fu, Yabo Wang, Tonghe Roper, Justin Bradley, Jeffrey D Patel, Pretesh Liu, Tian Yang, Xiaofeng
Published in
Physics in Medicine & Biology
Objective. CBCTs in image-guided radiotherapy provide crucial anatomy information for patient setup and plan evaluation. Longitudinal CBCT image registration could quantify the inter-fractional anatomic changes, e.g. tumor shrinkage, and daily OAR variation throughout the course of treatment. The purpose of this study is to propose an unsupervised ...
Cai, Emily Y De Caro, Christian Treb, Kevin Li, Ke
Published in
Physics in Medicine & Biology
Objective. Existing dual-layer flat panel detectors (DL-FPDs) use a thin scintillator layer to preferentially detect low-energy x-rays, followed by a permanent Cu filter to absorb residual low-energy x-rays, and finally, a thicker scintillator layer to preferentially detect high-energy x-rays. The image outputs of the two scintillator layers can be...
Miller, Zachary Pirasteh, Ali Johnson, Kevin M
Published in
Physics in Medicine & Biology
Objective. Model based deep learning (MBDL) has been challenging to apply to the reconstruction of 3D non-Cartesian MRI due to GPU memory demand because the entire volume is needed for data-consistency steps embedded in the model. This requirement makes holding even a single unroll in GPU memory difficult meaning memory efficient techniques used to...
Nadig, Vanessa Herweg, Katrin Chou, Mitch M C Lin, Jack W C Chin, Edmund Li, Chu-An Schulz, Volkmar Gundacker, Stefan
Published in
Physics in Medicine and Biology
Objective. Together with novel photodetector technologies and emerging electronic front-end designs, scintillator material research is one of the key aspects to obtain ultra-fast timing in time-of-flight positron emission tomography (TOF-PET). In the late 1990s, Cerium-doped lutetium–yttrium oxyorthosilicate (LYSO:Ce) has been established as the st...
Choi, Honggu Iyer, Rishyashring R Renteria, Carlos A Boppart, Stephen A
Published in
Physics in Medicine & Biology
Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane induces membrane displacement statistics that deviate from Brownian motion. The membrane dynamics from ion channel gating were imaged by phase-sensitive optical coherence microscopy. The distribution of optical displacements of the neuronal membrane showed a Lévy...
Mee, Stephen F Polan, Daniel F Dewaraja, Yuni K Cuneo, Kyle C Gemmete, Joseph J Evans, Joseph R Lawrence, Theodore S Dow, Janell S Mikell, Justin K
Published in
Physics in Medicine & Biology
Objective. 90Y selective internal radiation therapy (SIRT) treatment of hepatocellular carcinoma (HCC) can potentially underdose lesions, as identified on post-therapy PET/CT imaging. This study introduces a methodology and explores the feasibility for selectively treating SIRT-underdosed HCC lesions, or lesion subvolumes, with stereotactic body ra...
