Van den Heuvel, Frank Vella, Anna Fiorini, Francesca Brooke, Mark Hill, Mark Ryan, Anderson Maughan, Tim Giaccia, Amato
Published in
Physics in Medicine & Biology
Purpose. To introduce a methodology to predict tissue sparing effects in pulsed ultra-high dose rate radiation exposures which could be included in a dose-effect prediction system or treatment planning system and to illustrate it by using three published experiments. Methods and materials. The proposed system formalises the variability of oxygen le...
Delaunay, Rémi Hu, Yipeng Vercauteren, Tom
Published in
Physics in Medicine and Biology
Quasi-static ultrasound elastography (USE) is an imaging modality that measures deformation (i.e. strain) of tissue in response to an applied mechanical force. In USE, the strain modulus is traditionally obtained by deriving the displacement field estimated between a pair of radio-frequency data. In this work we propose a recurrent network architec...
Stavropoulou, A Szmul, A Chandy, E Veiga, C Landau, D McClelland, J R
Published in
Physics in Medicine and Biology
Quantifying parenchymal tissue changes in the lungs is imperative in furthering the study of radiation induced lung damage (RILD). Registering lung images from different time-points is a key step of this process. Traditional intensity-based registration approaches fail this task due to the considerable anatomical changes that occur between timepoin...
Leitão, David Teixeira, Rui Pedro A. G. Price, Anthony Uus, Alena Hajnal, Joseph V. Malik, Shaihan J.
This study presents a comparison of quantitative MRI methods based on an efficiency metric that quantifies their intrinsic ability to extract information about tissue parameters. Under a regime of unbiased parameter estimates, an intrinsic efficiency metric $\eta$ was derived for fully-sampled experiments which can be used to both optimize and comp...
Van den Heuvel, Frank Vella, Anna Fiorini, Francesca Brooke, Mark Hill, Mark A Maughan, Tim
Published in
Physics in Medicine and Biology
Purpose. To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA-damage resulting from ionising radiation at variable oxygenation levels. Methods. Oxygen fixation is treated as a stati...
Davey, Angela van Herk, Marcel Faivre-Finn, Corinne Brown, Sean McWilliam, Alan
Published in
Physics in Medicine and Biology
Purpose . 4D-CT is routine imaging for lung cancer patients treated with stereotactic body radiotherapy. No studies have investigated optimal 4D phase selection for radiomics. We aim to determine how phase data should be used to identify prognostic biomarkers for distant failure, and test whether stability assessment is required. A phase selection ...
Collins-Fekete, Charles-Antoine Dikaios, Nikolaos Bär, Esther Evans, Philip M
Published in
Physics in medicine and biology
In this study, we investigated the capacity of various ion beams available for radiotherapy to produce high quality relative stopping power map acquired from energy-loss measurements. The image quality metrics chosen to compare the different ions were signal-to-noise ratio (SNR) as a function of dose and spatial resolution. Geant4 Monte Carlo simul...
Veiga, Catarina Lim, Pei Anaya, Virginia Marin Chandy, Edward Ahmad, Reem D'Souza, Derek Gaze, Mark Moinuddin, Syed Gains, Jennifer
Published in
Physics in medicine and biology
Reducing radiation-induced side effects is one of the most important challenges in paediatric cancer treatment. Recently, there has been growing interest in using spatial normalisation to enable voxel-based analysis of radiation-induced toxicities in a variety of patient groups. The need to consider three-dimensional distribution of doses, rather t...
Bernstein, David Taylor, Alexandra Nill, Simeon Oelfke, Uwe
Published in
Physics in Medicine and Biology
Target volume delineation uncertainty (DU) is arguably one of the largest geometric uncertainties in radiotherapy that are accounted for using planning target volume (PTV) margins. Geometrical uncertainties are typically derived from a limited sample of patients. Consequently, the resultant margins are not tailored to individual patients. Furthermo...
Rothwell, B C Kirkby, N F Merchant, M J Chadwick, A L Lowe, M Mackay, R I Hendry, J H Kirkby, K J
Published in
Physics in medicine and biology
There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxy...
