Godefroy, Guillaume Arnal, Bastien Bossy, Emmanuel
Published in
Photoacoustics
Conventional photoacoustic imaging may suffer from the limited view and bandwidth of ultrasound transducers. A deep learning approach is proposed to handle these problems and is demonstrated both in simulations and in experiments on a multi-scale model of leaf skeleton. We employed an experimental approach to build the training and the test sets us...
Hysi, Eno Fadhel, Muhannad N Wang, Yanjie Sebastian, Joseph A Giles, Anoja Czarnota, Gregory J Exner, Agata A Kolios, Michael C
Published in
Photoacoustics
The development of novel anticancer therapies warrants the parallel development of biomarkers that can quantify their effectiveness. Photoacoustic imaging has the potential to measure changes in tumor vasculature during treatment. Establishing the accuracy of imaging biomarkers requires direct comparisons with gold histological standards. In this w...
Longo, Antonia Morscher, Stefan Najafababdi, Jaber Malekzadeh Jüstel, Dominik Zakian, Christian Ntziachristos, Vasilis
Published in
Photoacoustics
The Hessian-based Frangi vesselness filter is commonly used to enhance vasculature in optoacoustic (photoacoustic) images, but its accuracy and limitations have never been rigorously assessed. Here we validate the ability of the filter to enhance vessel-like structures in phantoms, and we introduce an experimental approach that uses measurements be...
Na, Shuai Yuan, Xiaoyun Lin, Li Isla, Julio Garrett, David Wang, Lihong V
Published in
Photoacoustics
A major challenge of transcranial human brain photoacoustic computed tomography (PACT) is correcting for the acoustic aberration induced by the skull. Here, we present a modified universal back-projection (UBP) method, termed layered UBP (L-UBP), that can de-aberrate the transcranial PA signals by accommodating the skull heterogeneity into conventi...
Han, Tao Yang, Meng Yang, Fang Zhao, Lingyi Jiang, Yuxin Li, Changhui
Published in
Photoacoustics
By providing complementary functional information, photoacoustic (PA) breast imaging based on the handheld ultrasound (US) probe has demonstrated promising potential for breast cancer diagnosis. However, the quantitative PA imaging primarily relies on the knowledge of the optical fluence distribution in the three-dimensional (3D) heterogeneous brea...
Wagner, Alexandra L. Danko, Vera Federle, Anna Klett, Daniel Simon, David Heiss, Rafael Jüngert, Jörg Uder, Michael Schett, Georg Neurath, Markus F.
...
Published in
Photoacoustics
Photo-or optoacoustic imaging (OAI) allows quantitative imaging of target tissues. Using multi-wavelength illumination with subsequent ultrasound detection, it may visualize a variety of different chromophores at centimeter depth. Despite its non-invasive, label-free advantages, the precision of repeated measurements for clinical applications is st...
Li, Lin Wu, Hanbo Hu, Shuai Yu, Yanfei Chen, Zhicong Wang, Pu Zhou, Liqun Li, Rui Yao, Lin Yue, Shuhua
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Published in
Photoacoustics
There is a need for accurate and rapid detection of renal cancer in clinic. Here, we integrated photoacoustic tomography (PAT) with ultrasound imaging in a single system, which achieved tissue imaging depth about 3 mm and imaging speed about 3.5 cm2/min. We used the wavelength at 1197 nm to map lipid distribution in normal renal tissues and clear c...
Zhou, Jingcheng Jokerst, Jesse V.
Published in
Photoacoustics
Photoacoustic imaging (PAI) has achieved remarkable growth in the past few decades since it takes advantage of both optical and ultrasound (US) imaging. In order to better promote the wide clinical applications of PAI, many miniaturized and portable PAI systems have recently been proposed. Most of these systems utilize fiber optic technologies. Her...
Sun, Mingjian Li, Chao Chen, Ningbo Zhao, Huangxuan Ma, Liyong Liu, Chengbo Shen, Yi Lin, Riqiang Gong, Xiaojing
Published in
Photoacoustics
Quantitative analysis of tumor vessels is of great significance for tumor staging and diagnosis. Photoacoustic imaging (PAI) has been proven to be an effective way to visualize comprehensive tumor vascular networks in three-dimensional (3D) volume, while previous studies only quantified the vessels projected in one plane. In this study, tumor vesse...
Humbert, Jana Will, Olga Peñate-Medina, Tuula Peñate-Medina, Oula Jansen, Olav Both, Marcus Glüer, Claus-Christian
Published in
Photoacoustics
Few reports quantitatively compare the performance of photoacoustic tomography (PAT) versus fluorescence molecular tomography (FMT) in vivo . We compared both modalities for the detection of signals from injected ICG liposomes in the tibial medullary space of 10 BALB/c mice in vivo and ex vivo . Signals significantly correlated between modalities (...
