Krama, Tatjana Krams, Ronalds Elferts, Didzis Sieving, Kathryn E Krams, Indrikis A
Published in
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Animals adjust their use of alarm calls depending on social environments. We tested whether dominant (adult) and subordinate (juvenile non-kin) male crested tits (Lophophanes cristatus) warn each other and heterospecific willow tits (Poecile montanus) across the wintering season. Birds rarely alarm called when feeding alone. Both adult and juvenile...
Ferdinand, Vanessa Pattenden, Elle Brightsmith, Donald J Hobson, Elizabeth A
Published in
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Animals gathered around a specific location or resource may represent mixed-species aggregations or mixed-species groups. Patterns of individuals choosing to join these groups can provide insight into the information processing underlying these decisions. However, we still have little understanding of how much information these decisions are based ...
Mazzolini, Andrea Mora, Thierry Walczak, Aleksandra M.
Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
Chronic infections of the human immunodeficiency virus (HIV) create a very complex coevolutionary process, where the virus tries to escape the continuously adapting host immune system. Quantitative details of this process are largely unknown and could help in disease treatment and vaccine development. Here we study a longitudinal dataset of ten HIV...
Avila, Piret Mullon, Charles
Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
Evolutionary game theory and the adaptive dynamics approach have made invaluable contributions to understanding how gradual evolution leads to adaptation when individuals interact. Here, we review some of the basic tools that have come out of these contributions to model the evolution of quantitative traits in complex populations. We collect togeth...
Grodwohl, Jean-Baptiste Parker, Geoff A
Published in
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Though the first attempts to introduce game theory into evolutionary biology failed, new formalism by Maynard Smith and Price in 1973 had almost instant success. We use information supplied by early workers to analyse how and why evolutionary game theory (EGT) spread so rapidly in its earliest years. EGT was a major tool for the rapidly expanding d...
Servajean, Richard Bitbol, Anne-Florence
Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases with population size, we find that the height of the first fitness peak encountered when start...
Logantha, Sunil Jit R. J. Yamanushi, Tomoko T. Absi, Mais Temple, Ian P. Kabuto, Hideaki Hirakawa, Eiichiro Quigley, Gillian Zhang, X. Gurney, Alison M. Hart, George
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Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
Patients with pulmonary arterial hypertension (PAH) have a high burden of arrhythmias, including arrhythmias arising from sinus node dysfunction, and the aim of this study was to investigate the effects of PAH on the sinus node. In the rat, PAH was induced by an injection of monocrotaline. Three weeks after injection, there was a decrease of the in...
Liu, Xiaoyan Ren, Lu Yu, Shandong Li, Gang He, Pengkang Yang, Qiaomei Wei, Xiaohong Thai, Phung N. Wu, Lin Huo, Yong
...
Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late I Na) and Ca2+/calmodulin-dependent protein kinase (CaMKII)-mediated arrhythmogenic activities in β-adrenergic overactivation-...
Langa, Paulina Shafaattalab, Sanam Goldspink, Paul H. Wolska, Beata M. Fernandes, Aurelia A. Tibbits, Glen F. Solaro, R. John
Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding mutant proteins of the sarcomere. We recently reported an upregulation of elements in the Notch signa...
Zhou, Yafei Huang, Wenjun Liu, Leiying Li, Anmao Jiang, Congshan Zhou, Rui Wang, Jie Tan, Xiaoqiu Huang, Christopher L.-H. Zhang, Yanmin
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Published in
Philosophical Transactions of the Royal Society B: Biological Sciences
We illustrate use of induced pluripotent stem cells (iPSCs) as platforms for investigating cardiomyocyte phenotypes in a human family pedigree exemplified by novel heterozygous RYR2-A1855D and SCN10A-Q1362H variants occurring alone and in combination. The proband, a four-month-old boy, presented with polymorphic ventricular tachycardia. Genetic tes...
