Published in Pharmacotherapy
The use of cisplatin is limited by the development of nephrotoxicity, with an incidence approaching 30%. It is unclear if a risk prediction score can effectively predict the development of nephrotoxicity throughout all cycles of cisplatin therapy among outpatients. Retrospective, observational study evaluating adult patients receiving cisplatin in ...
Published in Pharmacotherapy
The objective of this study was to establish physiologically based pharmacokinetic (PBPK) models of tramadol and its active metabolite O-desmethyltramadol (M1) and to explore the influence of CYP2D6 gene polymorphism on the pharmacokinetics of tramadol and M1. Furthermore, we used PBPK modeling to prospectively predict the extent of drug-drug inter...
Published in Pharmacotherapy
Nonsteroidal antiinflammatory drugs (NSAIDs) have been associated with increased risk of adverse cardiovascular events prompting labeling revisions cautioning their use among patients with cardiovascular disease (CVD). However, little is known regarding long-term trends in real-world prescribing of NSAIDs within the CVD population. We aimed to char...
Published in Pharmacotherapy
Increased public access to cannabis calls for a deeper understanding of cannabis's constituents and how they interact to induce clinical effects. Whereas trans-Δ9 -tetrahydrocannabinol (THC) is considered the main psychoactive component in cannabis, producing the associated "high" or "euphoria," various findings demonstrate medical potential for ca...
Published in Pharmacotherapy
Gastrointestinal (GI) malignancies are among the most commonly diagnosed cancers worldwide. Despite the introduction of targeted and immunotherapy agents in the treatment landscape, cytotoxic agents, such as fluoropyrimidines and irinotecan, remain as the cornerstone of chemotherapy for many of these tumors. Pharmacogenetics (PGx) is a rapidly evol...
Published in Pharmacotherapy
Opioid use has been associated with significant morbidity and mortality in the United States. Studies within kidney transplantation have also shown increased risk of mortality, graft loss, and complications in kidney transplant recipients who use opioids prior to transplant. The objective of this analysis was to identify if recent pretransplant opi...
Published in Pharmacotherapy
In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a comprehensive, easy to use, ototoxic profile of...
Published in Pharmacotherapy
Introduction Hydroxychloroquine (HCQ) for COVID‐19 is presently being used off‐label or within a clinical trial. Objectives We investigated a multinational COVID‐19 patient database of real world data containing outcomes and their relationship to HCQ use. The primary outcome was all‐cause mortality within 30 days follow‐up. Methods Retrospective co...
Published in Pharmacotherapy
Remdesivir is a direct‐acting nucleoside RNA polymerase inhibitor with activity against the novel SARS‐CoV‐2 virus used in the treatment of COVID‐19 pneumonia . Here we present two cases of suspected remdesivir‐associated acute liver failure (ALF) in which the liver failure improved following continuous infusion acetylcysteine and withdrawal of rem...
Published in Pharmacotherapy
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are associated with an increased risk of genitourinary infections in patients with type 2 diabetes mellitus (T2DM). It is unknown which factors may predispose patients to an increased risk of developing a genitourinary infection. To evaluate whether hemoglobin A1c levels and other patient-specific f...
