Liu, Wei Yan, Tingting Chen, Ken Yang, Li Benet, Leslie Z Zhai, Suodi
Published in
Pharmacotherapy
Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interactions to help formulate recommendations on the ...
Pai, Manjunath P Debacker, Kenneth C Derstine, Brian Sullivan, June Su, Grace L Wang, Stewart C
Published in
Pharmacotherapy
High-dose methotrexate (HD-MTX) is used to treat primary central nervous system lymphoma (PCNSL), but potential differences in MTX clearance (CL) due to obesity have not been studied. We characterized the relationship between HD-MTX CL and computed tomography (CT)-generated body composition (morphomic), body size descriptors, and laboratory measure...
Shoair, Osama A Cook, Elizabeth A Shipman, Denver Dunn, Rebecca L
Published in
Pharmacotherapy
Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are prevalent in patients with asthma. These disorders may increase asthma severity and decrease asthma control. No studies have evaluated the impact of achieving antidepressant target dose optimization compared with not achieving antidepressant target doses on asthma control in...
Lim, Sin Yin Sharan, Satish Woo, Sukyung
Published in
Pharmacotherapy
There is a large variation in cannabidiol (CBD) pharmacokinetics and little information on its bioavailability. This study aims to establish the CBD dose-exposure relationship and to evaluate the effects of dosage forms, food, and doses on CBD absorption. Single-dose (range: 5-6000 mg) CBD plasma concentration-time profiles administered as oral sol...
Yerke, Jason R Sacha, Gretchen L Scheraga, Rachel G Culver, Daniel A Abraham, Susamma Torbic, Heather Lam, Simon W Ammar, Mahmoud A Olman, Mitchell A Bauer, Seth R
...
Published in
Pharmacotherapy
Positive hemodynamic response to vasopressin after 6 hours of infusion was independently associated with lower mortality in a previous retrospective study of patients with septic shock. However, factors previously associated with higher plasma vasopressin concentration were not associated with response, and the relationship between plasma vasopress...
Eshetie, Tesfahun C Nguyen, Tuan A Gillam, Marianne H Kalisch Ellett, Lisa M
Published in
Pharmacotherapy
People with Alzheimer's disease (AD) often have multimorbidity and take multiple medicines. Yet few studies have examined medicine utilization for comorbidities comparing people with and without AD. The aim was to investigate the patterns of medication use for comorbidities in people with and without AD. An Australian population-based study was con...
Soukup, Paige Faust, Andrew C Edpuganti, Vindhya Putnam, William C McKinnell, James A
Published in
Pharmacotherapy
Ceftazidime-avibactam (CAZ-AVI) is a novel intravenous β-lactam/β-lactamase inhibitor combination used in the treatment of multidrug-resistant (MDR) gram-negative infections. Although renal dosing recommendations exist for the medication, limited data are available for dosing in patients receiving continuous renal replacement therapy. In this repor...
Dong, Lei Zhu, Li-Na Xie, Bao-Jie Li, Ji-Bin Ding, Tao Jiang, Yun-Fa Zhu, Zhong-Ning
Published in
Pharmacotherapy
To compare the effectiveness of different taxane-containing regimens and to identify the best strategy for the treatment of human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Network meta-analysis of 20 randomized controlled trials (RCTs). A total of 6577 patients with HER2-negative MBC who received treatment (...
van Nuland, Merel Bergman, Andries M Rosing, Hilde de Vries, Niels Huitema, Alwin D R Beijnen, Jos H
Published in
Pharmacotherapy
Enzalutamide is an oral agent for the treatment of metastatic castration-resistant prostate cancer (mCRPC); N-desmethyl enzalutamide is its active metabolite, which has clinically relevant anti-androgen capacities similar to enzalutamide, and carboxylic acid enzalutamide is an inactive metabolite. The aim of our study was to investigate the relatio...
Smalls, Danielle J Kiger, Reagan E Norris, LeAnn B Bennett, Charles L Love, Bryan L
Published in
Pharmacotherapy
Hepatitis B virus (HBV) is a global disease with significant morbidity and mortality. Worldwide, ~257 million people are chronically infected with HBV, defined as having a positive hepatitis B surface antigen, but millions more have prior HBV exposure indicated by positive hepatitis B core antibody. Reactivation of hepatitis B implies a sudden incr...
